SARMs vs Testosterone for Labs

sarms vs testosterone

In 13 years, testosterone prescription sales increased from $100 million to $2.7 billion. The large market increase is primarily from decades of ongoing research. There have been multiple FDA-approved products for male sexual dysfunction, hypogonadism, and more. 

Recently, researchers have been debating SARMs vs testosterone. These two androgen therapies differ in their tissue selectivity, reactions, and medical uses. Due to the nature of SARMs and limited research studies, it is impossible to thoroughly compare the two in extensive human studies. 

However, if you want the most up-to-date information for your next research topic, we have you covered. We will compare the similarities and differences between SARMs and testosterone. Keep reading on until the end and learn how you can get started with purchasing high-quality SARMs for your laboratory. 

What Is Testosterone?

Testosterone is a hormone found in men and women but is more abundant in males. It produces several distinct male characteristics, affecting sexual development, fertility, and more.

Testosterone also affects many secondary characteristics. These include things such as male hair patterns and skeletal muscle growth. Deficiencies can result in:

  • Hypogonadism
  • Reduced muscle mass
  • Low sperm count
  • Low libido

Along with hypogonadism, medical experts may use testosterone treatments for metastatic breast cancer or delayed puberty. Although with certain medical conditions, there are several benefits of taking testosterone, synthetic androgen toxicity can result in:

  • Overmasculinization
  • Hirsutism
  • Acne 
  • Clitoral enlargement (for females)
  • Cholestatic jaundice
  • Prostatic hypertrophy

Testosterone replacement therapy (TRT) comes in gel or injection format. The primary goal is restoring normal testosterone levels. However, TRT can have several virilizing effects, making alternative treatments friendlier for some research applications.

What Are SARMs?

SARMs are selective androgen receptor modulators. They are anabolic compounds binding to androgen receptors. There are several types of SARMs that are classified by a string of letters and numbers.

Some of the more common SARMs in studies are:

  • Ostarine
  • Ligandrol
  • Testolone
  • Andarine
  • Cardarine

Currently, SARMs are only approved for clinical or laboratory studies. The FDA has not approved any SARMs for human consumption due to limited research regarding:

  • Dosage
  • Side effects
  • Long term effects
  • Indications

There are several small studies focusing on breast cancer, prostate, stress urinary incontinence, and sarcopenia. Due to their effects on anabolic activity with minimal virilizing reactions, experts are interested in seeing how SARMs impact several different medical conditions. 

SARMs vs Testosterone

One of the bigger defining factors between androgen therapy such as TRT and SARMs is research and medical uses. Testosterone and steroid use are much more prevalent in studies, research, and treatments because they have existed for a longer time. 

The FDA approved specific testosterone therapy decades ago, and it has grown into a large market that primarily treats male hypogonadism. Recently, the FDA approved an oral TRT for hypogonadism called Tlando. 

However, while the growing market for TRT continues expanding under medical supervision, so do the unsupervised uses of steroids. Bodybuilders are notorious for using anabolic steroids for improved muscle mass and reduced body fat percentage.

Non-medical uses of anabolic steroids or continuous use can cause the testes to stop natural testosterone production. More extreme adverse reactions include liver or cardiac disease.  

SARMs vs TRT Research

Most TRT research centers around male hypogonadism. Clinical trials have also looked at secondary effects, such as cardiovascular disease or blood pressure reactions. 

On the other hand, SARMs have a more expansive, albeit limited, research pool. Unlike traditional androgen therapy, SARMs are more selective in their effects. 

Current research shows fewer systemic reactions while promoting:

  • Increased muscle mass
  • Exercise recovery
  • Potential male contraception
  • Reducing osteoporosis risks
  • Improving sexual dysfunction
  • Improving benign prostatic hyperplasia
  • Reducing muscle wasting

Another key difference is that SARMs are non-steroidal and tissue-specific. Each SARM could hold different benefits, depending on the agonistic or antagonist nature. 

Since they are not steroids, SARMs fall under a different classification called synthetic ligands. Ligands are molecules or atoms that bind to receptors.

In this case, SARMs bind to similar androgen receptors, promoting localized changes within the tissue receptors. The effects of SARMs in lab results include promising treatments for specific types of breast cancer.

These studies used RAD140 against other testosterone treatments. It is expected that, in time, more research will start comparing the two on their efficacy. 

What Does SARMs Do to Testosterone?

When looking at testosterone vs SARMs, it is critical that you examine the localized effects SARMs have on the body’s testosterone levels. SARMs indirectly increase free testosterone levels in some instances by blocking the binding of SHBG to testosterone. Prolonged exposure to SARMs may reduces testicular production of testosterone however again – studies are very limited. The combination of antagonist and agonist effects on androgen receptors makes it challenging to determine which SARMs will have the most profound effect on testosterone levels. 

For example, in comprehensive literature reviews from 2019, SARM BA321 bound to androgen and estrogen receptors. However, the researchers found it only restored bone loss without other androgenic effects.

SARMs with testosterone for muscle building could result in higher health risks. It could also impair natural testosterone production. More research is needed to see the effects of these two in controlled environments. 

Researching SARMs

SARMs vs testosterone is a highly debated topic. SARMs could hold the key to medical benefits that are unrealistic to expect from testosterone therapy. However, because of their infancy compared to testosterone, high-quality research is needed on SARMs. 

Purchasing SARMs for research can put you on the frontline of innovation and discovery. However, finding qualified and reputable sellers can make all the difference in your outcomes. 

At Sports Technology Labs, we undergo rigorous testing, ensuring every batch is of the highest quality. Contact Sports Technology Labs today and let us help with your SARMs needs. 

References

Bhasin, S. (2021, February 15). Testosterone replacement in aging men: An evidence-based patient-centric perspective. The Journal of Clinical Investigation. Retrieved July 2, 2022, from https://www.jci.org/articles/view/146607

Burmeister, M., Fincher, T., & Graham, W. (2020, June 18). Recreational Use of Selective Androgen Receptor Modulators. U.S. Pharmacist – The Leading Journal in Pharmacy. Retrieved July 2, 2022, from https://www.uspharmacist.com/article/recreational-use-of-selective-androgen-receptor-modulators

Contact. Sports Technology Labs. (2022, May 7). Retrieved July 2, 2022, from https://sportstechnologylabs.com/contact/

Kirksey, C. (2022, January 25). Your Ultimate 2021 SARMs Research Review. Sports Technology Labs. Retrieved July 2, 2022, from https://sportstechnologylabs.com/sarms-research/

Nassar, G., & Leslie, S. (2022, January 4). Physiology, testosterone – STATPEARLS – NCBI BOOKSHELF. Retrieved July 2, 2022, from https://www.ncbi.nlm.nih.gov/books/NBK526128/

Pharmacy Times. (2022, March 30). FDA approves oral testosterone replacement therapy for hypogonadism. Pharmacy Times. Retrieved July 2, 2022, from https://www.pharmacytimes.com/view/fda-approves-oral-testosterone-replacement-therapy-for-hypogonadism

Rogers, P. (2022, April 22). Why Anabolic Steroids Are Banned in Bodybuilding and Weightlifting. Verywell Fit. Retrieved July 2, 2022, from https://www.verywellfit.com/anabolic-steroids-bodybuilding-and-weight-training-3498211

Solomon, Z. J., Mirabal, J. R., Mazur, D. J., Kohn, T. P., Lipshultz, L. I., & Pastuszak, A. W. (2019, January 7). Selective Androgen Receptor Modulators (SARMs) – Current Knowledge and Clinical Applications. Sexual medicine reviews. Retrieved July 2, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326857/

Sports Technology Labs. (2022, May 12). Breast Cancer and RAD140: A Case Study Summary. Sports Technology Labs. Retrieved July 2, 2022, from https://sportstechnologylabs.com/breast-cancer-and-rad140/

SARMs vs Testosterone for Labs