Hot Deal! GET 10% OFF when you subscribe to our newsletter ✉️ Pay with Bitcoin for another 10% OFF! 👏

Liquid Cardarine (GW501516) – 20MG/ML



Selling fast! Get yours today! Same-day shipping available

High Quality Liquid Cardarine for Sale

Cardarine, also known as GW501516 or Endurobol, is a PPAR (peroxisome proliferator-activated receptor) agonist and ligand-activated transcription factor that binds to receptors in skeletal muscle tissue and body fat and pushes skeletal muscle cells towards preferential lipid utilization and fat burning. PPAR is also involved in inflammation, glucose homeostasis, as well as cell proliferation, differentiation, and apoptosis, suggesting potential anti-aging effects of PPAR agonists.

PPAR are located in greatest concentration in tissues with high metabolic rates like skeletal muscle, intestine, liver, heart, and kidney. GW-501516 is often wrongly classified as a selective androgen receptor modulator (SARM). As a PPAR, it shares certain commonalities with SARMs but differs from them in a few important ways. GW 501516 does not affect androgen receptors or alter testosterone levels however it does have a key involvement in energy metabolism.

Cardarine Mechanism of Action

Invented in the early 1990s, Cardarine is also known by a number of alternate names, including GW1516 and GSK-516. It displays high affinity (Ki = 1 nM) and potency for PPARδ with over 1,000-fold selectivity over PPARα and PPARγ. Binding of GW501516 to PPARδ recruits the coactivator PGC-1α. The PPARδ/coactivator complex in turn upregulates the expression of proteins involved in energy expenditure. By activating AMP-activated protein kinase, it is widely believed to provide a broad range of experimental effects currently being tested in research such as:

  • Increases fatty acid oxidation and promotes fat loss
  • Lower LDL cholesterol (“bad cholesterol”)
  • Higher HDL cholesterol (“good cholesterol”)
  • Increases endurance
  • Reduces inflammation
  • Decreases insulin resistance and improves glucose tolerance

Function of PPAR Agonists

Data indicates that PPAR activity preserves glucose for use in tissues like the brain while promoting the mobilization of fatty acids for muscular endurance. PPAR has also been observed to play an important role in temperature regulation, inflammation mediation, mitochondrial respiration, keratinocyte differentiation, and skin and muscle repair. Molecular analyses revealed that PPAR regulates the expression of genes associated with contractile proteins, lipid oxidation, and mitochondrial biogenesis.

PPAR Effects during Fasting

The effects of PPAR are observed in particular during fasting, when free fatty acids are released into the blood. A study in PPAR-null mice demonstrated that the absence of PPAR results in elevated free fatty acids during fasting, lipid accumulation in the liver and heart, low blood sugar, low body temperature, ketones in urine, and ultimately a premature death. Mice naturally adapt to high free fatty acid levels during fasting through induction of cardiac and hepatic PPAR genes that improve fatty acid uptake and oxidation.

The benefits and side effects of GW501516 however, have not been confirmed by the Food and Drug Administration (FDA) and like other SARMs for sale, it should be used for research purposes only. Due to its tendency to increase endurance and energy, the World Anti Doping Agency (WADA) has banned the use of Cardarine in professional sports and several athletes have tested positive for Cardarine and were dismissed as this chemical is only for researchers and clinical trials.

Studies including Cardarine

A number of animal studies have been performed that point to Cardarine’s ability to enhance certain physiological processes related to energy metabolism as well as potential improvements in blood lipids:

  • One study on mice found that GW501516 promotes fatty acid oxidation and fat burning in skeletal muscle tissue and alleviates metabolic syndrome.
  • Another study discovered that peroxisome proliferator-activated receptors can markedly increase running endurance in Kunming mice.
  • Yet another study on mice revealed that PPARs augment exercise endurance by preventing the exhaustion of glucose (“hitting the wall”).
  • A study involving obese rhesus monkeys found that GW 501516 increased high-density lipoprotein (HDL) and lowered very-low-density lipoprotein (VLDL), indicating potential cardioprotective effects from Cardarine.
  • Two separate phase II clinical studies found positive effects of Cardarine on obesity, diabetes, dyslipidemia, and cardiovascular disease, as well as suppression in macrophage-derived inflammation.
  • A study in rats that were fed a high fructose diet found that GW 501516 reduced inflammation markers, especially in the liver, and increased the expression of genes that regulate beta-oxidation.

Side Effects of Cardarine

While Cardarine is not known to cause androgenic side effects like anabolic androgenic steroids, data in rats indicates that doses of 3mg/kg/day (180-240mg per day in the average 60-80kg adult), significantly higher than those used in mammalian trails, caused cancer to develop quickly in several organs. Anecdotal data online indicates little in the way of noticeable side effects but more research is necessary to determine the overall safety profile of GW501516 before it can be approved for human use by the FDA.

Data on Our Liquid Cardarine for Sale

CAS Number: 317318-70-0

Formula: C21H18F3NO3S2

Molar Mass: 453.498 g/mol

Half life: 16 – 24 hours

Class: PPAR Agonist

Storage: Store in a cool dry place away from direct sunlight to maximize shelf life.

  • 30ml Liquid Cardarine per bottle with 20 milligrams per milliliter.
  • Includes graduated 1mL glass pipette for convenient measurement.
  • Glass bottle with UV resistance to minimize degradation.
  • Tamper-proof seal to ensure safety in transit.
  • Less than 5% variance in concentration, guaranteeing consistency.
  • Formulated and packaged to prevent evaporation in storage.

This preparation is for laboratory research purposes only and is not approved by the FDA for human consumption. Cardarine / GW501516 IS NOT A DIETARY OR SPORTS SUPPLEMENT.

Cardarine FAQ

GW 501516 does not interact with the androgen receptor at all so it does not cause suppression of natural testosterone.

Cardarine is non-hormonal and is not known to interrupt menstrual cycles or cause virilization in female test subjects. Quantities as high as 18mg per day have been used in clinical trails for females. Pregnant women or women who may become pregnant should not engage in clinical research with Cardarine.

GW501516 has been shown to increase HDL and decrease LDL in rhesus monkeys.

While Cardarine is often sold and marketed alongside of SARMs, it is in fact a PPAR agonist and binds and activates PPAR receptors in the body. These receptors have limited involvement in anabolism, and are rather involved in reducing inflammation and improving energy metabolism.

Why is Sports Technology Labs the best place to buy Cardarine online?

Buy Cardarine

A recent study involving chemical analyses of 44 different products sold and marketed as SARMs on the internet revealed that quality control in this industry varies greatly from one company to the next. Only 52% of the products tested contained the product advertised, 59% contained amounts that differed from the label, a shocking 39% contained other unapproved drugs, 25% contained substances not listed on the label, and 9% contained no active substance at all. It is critical when performing research with SARMs to only purchase the highest quality, verified by third party analysis.

If you are trying to figure out where to buy Cardarine, what is considered by many researchers to be one of the best SARMs for cutting bodyfat, there appears to be no shortage of options out there. Sports Technology Labs is the best place to buy Cardarine online because of their consistent, verifiable high quality products, safe bottling and packaging, fast shipping, and great customer service. Our Cardarine is also available in pure powder form.

When you buy SARMs from Sports Technology Labs you are choosing the highest quality ingredients. Minimum 98% pure compounds tested and certified by accredited American third party labs, suspended in USP grade (the highest grade) PEG400, bottled in America. Our products come in glass bottles with fixed glass droppers to prevent the leaching of unwanted plasticizers like BPA, and prevent contamination from having to use external measuring tools.

We run a transparent business, with no discreet payment methods necessary and no misrepresentation of our products, only the highest quality research chemicals available online, secured by our 60-day money-back guarantee. We offer free shipping on orders over $149 and if you need the products in a hurry we offer express shipping as well. Customers that sign up for our email list get 10% off, and an additional 10% off for payment with cryptocurrency.

At Sports Technology Labs you can find SARMs for sale, including the highest quality Cardarine for sale anywhere on the internet.  That’s why we are confident in our claim that we offer the best GW 501516 for sale on the market today. And if you have any questions about our liquid GW501516 products, you can also contact us and we’ll respond as soon as possible.

Abuse Warning

Cardarine is an investigational compound still awaiting FDA approval and is not a dietary supplement. At Sports Technology Labs we are chemical suppliers, not medical doctors, and our expertise is sourcing and quality control. Sports Technology Labs does not encourage or condone consumer use of SARMs products, they are for research purposes only.

SARMs should only be used under the supervision and direction of a medical doctor or designated research authority. We strongly discourage the SARMs for performance enhancement in sports and bodybuilding as these products are not FDA approved. We warn against “bro science” and peer consensus when making decisions related to the appropriateness of participating in an authorized clinical trial with these compounds.

Scientific References:

1. T. Tanaka et al., Activation of peroxisome proliferator-activated receptor δ induces fatty acid β-oxidation in skeletal muscle and attenuates metabolic syndrome, Proc. Natl. Acad. Sci. U.S.A., vol. 100, no. 26, pp. 15924–15929, Dec. 2003

2. Chen, W. et al. A metabolomic study of the PPARd agonist GW501516 for enhancing running endurance in Kunming mice. Sci. Rep. 5, 09884; doi: 10.1038/srep09884 (2015)

3. Fan W., Waizenegger W., Lin C.S., Sorrentino V., He M.-X., Wall C.E., Li H., Liddle C., Yu R.T., Atkins A.R., et al. PPARδ Promotes Running Endurance by Preserving Glucose. Cell Metab. 2017;25:1186–1193.e1184. doi: 10.1016/j.cmet.2017.04.006

4. What is GW501516 (aka cardarine) Sports Technology Labs 2023.

5. Oliver WR Jr, Shenk JL, Snaith MR, Russell CS, Plunket KD, Bodkin NL, Lewis MC, Winegar DA, Sznaidman ML, Lambert MH, Xu HE, Sternbach DD, Kliewer SA, Hansen BC, Willson TM. A selective peroxisome proliferator-activated receptor delta agonist promotes reverse cholesterol transport. Proc Natl Acad Sci U S A. 2001 Apr 24;98(9):5306-11. doi: 10.1073/pnas.091021198. Epub 2001 Apr 17. PMID: 11309497; PMCID: PMC33205.

6. Sprecher DL. Lipids, lipoproteins, and peroxisome proliferator activated receptor-delta. Am J Cardiol. 2007 Dec 3;100(11 A):n20-4. doi: 10.1016/j.amjcard.2007.08.009. PMID: 18047848.

7. Barish GD, Narkar VA, Evans RM. PPAR delta: a dagger in the heart of the metabolic syndrome. J Clin Invest. 2006 Mar;116(3):590-7. doi: 10.1172/JCI27955. PMID: 16511591; PMCID: PMC1386117.

8. Dressel U, Allen TL, Pippal JB, Rohde PR, Lau P, Muscat GE. The peroxisome proliferator-activated receptor beta/delta agonist, GW501516, regulates the expression of genes involved in lipid catabolism and energy uncoupling in skeletal muscle cells. Mol Endocrinol. 2003 Dec;17(12):2477-93. doi: 10.1210/me.2003-0151. Epub 2003 Oct 2. PMID: 14525954.

9. Sahebkar A, Chew GT, Watts GF. New peroxisome proliferator-activated receptor agonists: potential treatments for atherogenic dyslipidemia and non-alcoholic fatty liver disease. Expert Opin Pharmacother. 2014 Mar;15(4):493-503. doi: 10.1517/14656566.2014.876992. Epub 2014 Jan 16. PMID: 24428677.

10. Teresa Coll, David Álvarez-Guardia, Emma Barroso, Anna Maria Gómez-Foix, Xavier Palomer, Juan C. Laguna, Manuel Vázquez-Carrera, Activation of Peroxisome Proliferator-Activated Receptor-δ by GW501516 Prevents Fatty Acid-Induced Nuclear Factor-κB Activation and Insulin Resistance in Skeletal Muscle Cells, Endocrinology, Volume 151, Issue 4, 1 April 2010, Pages 1560–1569

11. Magliano, D.C., Penna-de-Carvalho, A., Vazquez-Carrera, M. et al. Short-term administration of GW501516 improves inflammatory state in white adipose tissue and liver damage in high-fructose-fed mice through modulation of the renin-angiotensin system. Endocrine 50, 355–367 (2015).

12. Van Wagoner RM, Eichner A, Bhasin S, Deuster PA, Eichner D. Chemical Composition and Labeling of Substances Marketed as Selective Androgen Receptor Modulators and Sold via the Internet. JAMA. 2017 Nov 28;318(20):2004-2010. doi: 10.1001/jama.2017.17069. Erratum in: JAMA. 2018 Feb 20;319(7):724. PMID: 29183075; PMCID: PMC5820696.

13. Burri L, Thoresen GH, Berge RK. The Role of PPARα Activation in Liver and Muscle. PPAR Res. 2010;2010:542359. doi: 10.1155/2010/542359. Epub 2010 Aug 18. PMID: 20847941; PMCID: PMC2933910.

14. Leone TC, Weinheimer CJ, Kelly DP. A critical role for the peroxisome proliferator-activated receptor alpha (PPARalpha) in the cellular fasting response: the PPARalpha-null mouse as a model of fatty acid oxidation disorders. Proc Natl Acad Sci U S A. 1999 Jun 22;96(13):7473-8. doi: 10.1073/pnas.96.13.7473. PMID: 10377439; PMCID: PMC22110.

15. Kersten S, Seydoux J, Peters JM, Gonzalez FJ, Desvergne B, Wahli W. Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fasting. J Clin Invest. 1999 Jun;103(11):1489-98. doi: 10.1172/JCI6223. PMID: 10359558; PMCID: PMC408372.