Description
High Quality Liquid SR9009 for Sale
Sports Technology Labs is pleased to offer the highest quality Stenabolic for sale. Stenabolic (SR9009) is an agonist of the Rev-ErbA protein. This protein can be found in various parts of the body, including the liver and the skeletomuscular system. Studies have demonstrated it’s effects on regulating circadian rhythms, acting on fat-storing cells, and influencing lipid and glucose metabolism in the liver. Although SR9009 is not a selective androgen receptor modulator (SARM), it binds to Rev-ErBA and results in many similar effects as well as others.
SR9009 was developed in 2013 at The Scripps Research Institute (now known as Scripps Research). Early on, SR9009 was found to be highly effective in increasing the metabolic activity and skeletal muscle growth in treated mice. It does not affect endogenous testosterone levels. SR9009 is considered by many researchers to be the best SARM for cutting bodyfat and Sports Technology Labs is the best place to buy Stenabolic online.
SR9009 has demonstrated a variety of effects in test subjects such as:
- Increased resting metabolic rate
- Cardioprotection
- Regulation of circadian rhythm and sleep patterns
- Enhanced endurance
- Weight loss
- Lowered cholesterol levels
- Lowered bodily inflammation
- Arterial Plaque management
SR9009 has shown potential in conditions such as heart failure, COPD (chronic obstructive pulmonary disease), and metabolic syndrome.
More research needs to be done on human subjects. Studies performed on animals have shown that SR9009 holds promise as a health-enhancing product:
SR9009 may one day gain widespread acceptance as “exercise in a bottle.” Nevertheless, SR9009 has yet to be officially approved by the Food and Drug Administration (FDA) for human usage. Therefore, it should be considered for laboratory research purposes only at present, not as a complement to aerobic exercise.
SR9009 and Circadian Rhythm
Synthetic REV-ERB ligands have been shown to alter circadian behavior in mice and the circadian pattern of core clock gene expression in the hypothalamus. This was also seen in a variety of metabolic genes present in the liver, skeletal muscle, and adipose tissues, leading to an increase in energy expenditure.
When treatment with a REV-ERB agonist was administered to diet-induced obese mice, obesity decreased as fat mass was reduced, and dyslipidemia and hyperglycemia were markedly improved. These results indicate that synthetic REV-ERB ligands that target the circadian rhythm may be beneficial for treating both sleep disorders and metabolic diseases.
SR 9009 and Energy Metabolism
Administration of the REV-ERBα agonist SR9009 has been shown to affect energy homeostasis in animals. Results of a study on goldfish showed that SR9009 inhibited feeding and decreased body weight and length gain. In addition, the abundance of ghrelin mRNA was lowered in the intestine while that of leptin-aI increased in the liver.
SR9009 also decreased plasma glucose levels coupled with higher glycolysis and lower gluconeogenesis rate in the liver, while lipid levels and lipogenic enzyme activities were reduced as well. Energy expenditure by locomotor activity remained unaffected. All results point towards REV-ERBα activation via SR9009 promoting a negative energy balance by reducing energetic inputs and regulating lipid and glucose metabolism.
SR9009 and Endurance
A 2013 study found that mice given SR9009 could run longer distances and for longer durations than normal mice.
Overexpression of Rev-erb-α in vitro has been shown to increase the amount of mitochondria and improve its respiratory capacity. This is a different mechanism than the way that cardarine increases endurance Additionally, overexpression or pharmacological activation of Rev-erb-α in vivo resulted in an increased exercise capacity. These studies suggest that Rev-erb-α may one day be used as a pharmacological target to improve muscle oxidative function by regulating gene networks governing mitochondrial number and performance.
SR9009 and Cardioprotection
Research conducted on REV-ERB deficient mice revealed significant cardiac myopathy after transverse aortic constriction compared to wild-type control mice, indicating the importance of REV-ERB in protecting the heart from pressure overload. Interestingly, SR9009 was still able to provide cardioprotective effects even in REV-ERBα/β cardiac-specific double knockout mice (cDKO) mice.
Additionally, when given at peak or trough points of REV-ERB expression, SR9009 had similar levels of cardioprotection, suggesting that some cardioprotective properties exist outside of REV-ERB. These findings further show that deletion of REV-ERB accelerates adverse cardiac remodeling in response to pressure overload and illustrates the independent cardioprotective aspect of SR9009 with regard to pressure overload.
SR 9009 and the Lungs
In vitro experiments conducted demonstrated that pharmacological activation of Rev-Erbα with SR9009 can reduce the inflammatory response in lung injury by suppressing TLR4-induced NF-κB activation. SR9009 treatment was effective in providing beneficial effects to metabolism, as it could ameliorate acidosis and hypoxemia by reducing arterial PaCO2 and increasing arterial PaO2, SO2, HCO3 -, lactic acid concentration, and blood PH. These results demonstrate that SR9009 treatment can lessen sepsis-induced lung injury and suggest targeting Rev-Erbα may be a promising strategy for preventing and managing acute lung injury.
Cellular research investigates the anti-tumor effects of SR9009 in the lungs. This data established that SR9009 is specifically lethal to both chemosensitive and chemoresistant Small cell Lung cancer cells. REV-ERBα was found to be involved in the antitumor effect of SR9009. Additionally, the core autophagy gene Atg5 was identified as a direct downstream target of REV-ERBα, which was suppressed by the REV-ERB agonist. The interaction between REV-ERBα and this autophagy gene prevented autophagy activity, thereby leading to SR9009 cytotoxicity in SCLC cells.
Data on Our Liquid SR9009 for Sale
CAS Number: 1379686-30-2
Formula: C20H24ClN3O4S
Molar Mass: 437.940 g/mol
Class: Rev-ERB agonist
Storage: Store in a cool dry place away from direct sunlight to maximize shelf life.
- 30ml Liquid SR 9009 per bottle with 20 milligrams per milliliter.
- Includes graduated 1mL glass pipette for convenient measurement.
- Glass bottle with UV resistance to minimize degradation.
- Tamper-proof seal to ensure safety in transit.
- Less than 5% variance in concentration, guaranteeing consistency.
- Formulated and packaged to prevent evaporation in storage.
This preparation is for laboratory research purposes only and is not approved by the FDA for human use. SR009/Stenabolic IS NOT A DIETARY OR SPORTS SUPPLEMENT.
SR9009 FAQs
Why is Sports Technology Labs the best place to buy SR9009 online?
Many sites advertise the sale of SARMs, but Sports Technology Labs is the best place to buy SR9009 online because of their consistent, verifiable quality, safer bottling and packaging, and outstanding customer service. Our SR-9009 is also available in pure powder form. Anyone who is looking for SARMs for sale has a number of options. There are more than a few websites on the internet offering Stenabolic for sale. But not all of these sellers are equally reputable. Simply put, it’s hard to be certain of the quality of the products sold by some of these mysterious websites, or what they will do with your personal information.
When you buy SARMs from Sports Technology Labs you are choosing the highest quality ingredients. Minimum 98% pure compounds tested and certified by accredited American third party labs, suspended in USP grade (the highest grade) PEG400, bottled in America. Our products come in glass bottles with fixed glass droppers to prevent the leaching of unwanted plasticizers like BPA, and prevent contamination between testing with external measuring tools.
We run a transparent business, with no discreet payment methods necessary and no misrepresentation of our products, only the highest quality research chemicals available online, secured by our 60-day money-back guarantee. We offer free USPS shipping on orders over $149 and if you need the products in a hurry we offer express shipping as well. Customers that sign up for our email list get 10% off, and an additional 10% off for payment with cryptocurrency.
We are dedicated to ensuring customer satisfaction. You are always welcome to contact us with your questions, and we’ll get back to you shortly.
Abuse Warning
SR9009 is an investigational compound still awaiting FDA approval and is not a dietary supplement. At Sports Technology Labs we are chemical suppliers, not medical doctors, and our expertise is sourcing and quality control. Sports Technology Labs does not encourage or condone consumer use of SARMs products, they are for research purposes only.
SARMs should only be used under the supervision and direction of a medical doctor or designated research authority. We strongly discourage the use of SARMs for performance enhancement in sports and bodybuilding, and warn against “bro science” and peer consensus when making decisions about human health.
Scientific References:
1. Solt, L., Wang, Y., Banerjee, S. et al. Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists. Nature 485, 62–68 (2012).
2. Woldt, E., Sebti, Y., Solt, L. et al. Rev-erb-α modulates skeletal muscle oxidative capacity by regulating mitochondrial biogenesis and autophagy. Nat Med 19, 1039–1046 (2013).
3. Li H, Song S, Tien CL, Qi L, Graves A, Nasiotis E, Burris TP, Zhao Y, Sun Z, Zhang L. SR9009 improves heart function after pressure overload independent of cardiac REV-ERB. Front Cardiovasc Med. 2022 Jul 14;9:952114. doi: 10.3389/fcvm.2022.952114.
4. Hu M, Zhang L, Cao J, Jiang Y, Liu G. SR9009 Regulates Acute Lung Injury in Mice Induced by Sepsis. Can Respir J. 2022 Jul 1;2022:5802938. doi: 10.1155/2022/5802938. PMID: 35814267; PMCID: PMC9270156.
5. Shen W, Zhang W, Ye W, Wang H, Zhang Q, Shen J, Hong Q, Li X, Wen G, Wei T, Zhang J. SR9009 induces a REV-ERB dependent anti-small-cell lung cancer effect through inhibition of autophagy. Theranostics. 2020 Mar 15;10(10):4466-4480. doi: 10.7150/thno.42478. PMID: 32292508; PMCID: PMC7150483.
6. Saiz N, Herrera-Castillo L, Isorna E, Delgado MJ, Conde-Sieira M, Soengas JL, de Pedro N. REV-ERBα Agonist SR9009 Promotes a Negative Energy Balance in Goldfish. Int J Mol Sci. 2022 Mar 8;23(6):2921. doi: 10.3390/ijms23062921. PMID: 35328345; PMCID: PMC8955992.
