RAD 140, also known as Testolone, is one of several selective androgen receptor modulators (SARMs) that was initially developed as a potential alternative to testosterone replacement therapy. It should not be confused with it’s esterified form, RAD 150, also known as TLB 150. RAD140 binds to the androgen receptors (AR) in a selective manner and does not produce the full range of androgenic effects as similar substances like testosterone, DHT, or anabolic steroids.
RAD140 demonstrated excellent affinity for the AR (Ki = 7 nM), higher even than DHT and most anabolic steroids. For reference, the the affinity for the androgen receptor (AR) for Testosterone in a recent preclinical model was 29 nM, and 10 nM for DHT. Unlike testosterone and most other AR mediated anabolic agents, Testolone is orally bioavailable so it does not require injection for proper absorption and it is considered by many researchers to be one of the best SARMs for bulking and adding lean body mass.
Testolone is a fairly recent addition to the list of SARMs for sale; it was developed in 2010 as a possible treatment for osteoporosis and muscle gains. More recent testing performed on rats and primates as well as clinical trials have indicated that it may provide additional benefits as well.
A study on young male cynomolgus monkeys investigated the anabolic effects of 28 days of RAD140 at a dosage of 0.01mg/kg, 0.1mg/kg, and 1mg/kg per day. A mean weight gain of 10% was observed in both the 0.1mg/kg/day group and the 1mg/kg/day group, indicating a quantity response curve that leveled off and provided no additional benefit with higher quantities.
There was no consistent effect on body fat mass in either group, however muscle mass increased in the 0.1 and 1mg/kg/day groups. No significant increases in liver enzymes or prostate weight were reported in either group suggesting a high level of selectivity for androgen receptors in muscle tissue.
Androgens have shown clinical significance in preventing neuronal apoptosis and improving cognitive function in Alzheimer’s Disease (AD), primarily through a nongenomic mechanism of the Androgen Receptor (AR). Rapid phosphoinositide 3-kinase/Akt signaling, activated by androgens, regulates the expression of proteins linked to apoptosis such as bax, seladin 1, survivin, XIAP, and bcl-xl.
Androgens can also maintain the integrity of neurons and thus improve cognitive function. Studies have shown that Aβ impairs synaptic structure and function of hippocampal neurons which is reversed by androgen administration resulting in improved cognitive performances in AD animal models. Although the underlying exact mechanisms are not yet fully understood, androgen’s action of inhibiting Aβ-induced apoptosis appears to play a role.
A 2014 study investigated the neuroprotective effects of RAD140 on cultured neurons and male rats that were lesioned with kianate. The experiment included two parts – one in vitro involving cell cultures and another in vivo through animal testing. Results from the in vitro study showed that RAD140 was able to prevent cell death and restore mitochondrial membrane potential, indicating that it could offer neuroprotection much like testosterone and other androgens investigated for these effects.
The in vivo experiment tested the efficacy of RAD140 on male rats with kainate-induced seizures and showed a significant reduction in seizure activity compared to controls. Overall, this study demonstrated that RAD140 is capable of offering neuroprotection both in vitro and in vivo, suggesting it may one day have a place in treating neurological disorders.
Another study on rats found that RAD140 had neuroprotective benefits of a kind that may prevent Alzheimer’s disease and similar disorders, and may be safer than conventional testosterone therapy The group treated with 3 mg/kg RAD140 was able to replicate the same level of muscle tissue growth as the group treated with 1 mg/kg Testosterone, with about half of the androgenic activity in the prostate.
A 2017 study investigated the effects of RAD140 on breast cancer cells. The study evaluated the efficacy of RAD140 in inhibiting the growth of breast cancer cells that were positive for both androgen receptors (ARs) and estrogen receptors (ERs). Results showed that in in vivo and in vitro models of AR/ER+ breast cancer, RAD140 was able to significantly reduce the growth and metastases of breast cancer cells without disrupting their cell cycle, indicating it could be a promising therapy for treating such cancers.
Moreover, the study also showed that RAD140 had distinct mechanisms of action from those of anti-estrogens and aromatase inhibitors, which suggests that it could provide an additional therapeutic approach to treating hormone-sensitive breast cancers. Overall, this study suggests that RAD140 could be a potential option for AR/ER positive breast cancer but more data is needed to determine its safety relative to other methods utilized at this time.
In Vitro, the RAD140 SARM has produced a wide array of effects including:
However, it must be understood that the Food and Drug Administration (FDA) has not confirmed any health effects of RAD 140 for human beings or approved it for human use, and the drug should be used for laboratory research use only. Anecdotal reports indicate a potential for testosterone suppression and other side effects in males from RAD 140 administration.
While RAD140 and other SARMs do not cause androgenic side effects to the same extent as anabolic steroids like Testosterone, reports have revealed the potential for nausea, aggression, reduction in natural testosterone levels, or mild male pattern hair loss from the use of RAD 140. A single-member case report indicated drug-induced liver injury after 11 months of the use of an anti-depressant, as well as intermittent use of RAD 140 and LGD-4033. The limitations of this study however are the fact that it includes only one test subject, 11 months of concurrent antidepressant use, the quality and quantity of SARMs used by the subject were not monitored, and additional comorbidities were not investigated.
Several case reports exist indicating the potential for selective androgen receptor modulators to contribute to liver injury but none involve a significant sample size or test controls to date. Like other SARMs, RAD 140 may trigger a negative feedback loop and a reduction in natural testosterone production and testicle size though further research is needed to determine the likelihood and severity of this occurrence.
CAS Number: 1182367-47-0
Molar Mass: 393.83 g/mol
Half life: 44.7 hours
Class: Selective Androgen Receptor Modulator
Storage: Store in a cool dry place away from direct sunlight to maximize shelf life.
This preparation is for laboratory research purposes only and is not approved by the FDA for human consumption. RAD140/Testolone IS NOT A DIETARY OR SPORTS SUPPLEMENT.
A study performed in 2010 found that after 28 days of testing RAD140, the testosterone levels in all three groups was suppressed to approximately 200−300 ng/dL, with similar suppression in all groups, although testosterone levels were significantly different for only the 0.01 mg/kg group (p < 0.05).
Although it is not known to be particularly androgenic, there is little available information regarding the safety profile of RAD 140 in female test subjects and females should be cautious with participating in clinical research with RAD 140 until more information is available.
While it is not known to be particularly androgenic on its own, RAD 140 administration can free testosterone that is otherwise bound to SHBG in the male body and this can indirectly increase the risk of hair loss.
A recent study involving chemical analyses of 44 different products sold and marketed as SARMs on the internet revealed that quality control in this industry varies greatly from one company to the next. Only 52% of the products tested contained the product advertised, 59% contained amounts that differed from the label, a shocking 39% contained other unapproved drugs, 25% contained substances not listed on the label, and 9% contained no active substance at all. It is critical when performing research with SARMs to only purchase the highest quality, verified by third party analysis.
Many websites offer RAD140 for sale but Sports Technology Labs is the best place to buy RAD 140 online because of their consistent, verifiable high quality products, safer bottling and packaging, fast shipping, and great customer service. The internet seems to be full of sites offering Testolone and related substances. This may leave you wondering which of these many options you should select. Some websites are more interested in making quick cash than in ensuring that their customers receive dependable products. That’s why you need to buy only from websites with established quality-control procedures.
When you buy SARMs from Sports Technology Labs you are choosing the highest quality ingredients. Minimum 98% pure compounds tested and certified by accredited American third party labs, suspended in USP grade (the highest grade) PEG400, bottled in America. Our products come in glass bottles with fixed glass droppers to prevent the leaching of unwanted plasticizers like BPA and extend shelf life, and prevent contamination between uses with external measuring tools.
We run a transparent business, with no discreet payment methods necessary and no misrepresentation of our products, only the highest quality research chemicals available online, secured by our 60-day money-back guarantee. For orders totaling $149 or more, we offer free shipping. If you’re in a hurry to receive your products, we also provide express shipping options. Additionally, customers who sign up for our email list receive a 10% discount, and an additional 10% off when paying with cryptocurrency. When you choose Sports Technology Labs, you are choosing the best place to buy RAD140. Our RAD-140 is also available in pure powder form.
We are also committed to offering first-rate customer service. You’re always welcome to contact us with any questions or concerns you have about our RAD140 for sale.
RAD 140 is an investigational compound still awaiting FDA approval and is not a dietary supplement. At Sports Technology Labs we are chemical suppliers, not medical doctors, and our expertise is sourcing and quality control. Sports Technology Labs does not encourage or condone consumer use of SARMs products, they are for research purposes only.
SARMs should only be used under the supervision and direction of a medical doctor or designated research authority. We strongly discourage the use of SARMs for performance enhancement in sports and bodybuilding, and warn against “bro science” and peer consensus when making decisions about human health.
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