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Description

RAD 140, also known as Testolone, is a selective androgen receptor modulator (SARM) that holds great promise as an alternative to testosterone replacement therapy. Like all SARMs, RAD140 binds to the androgen receptors (AR) in a selective manner and does not produce the full range of androgenic effects as similar substances like testosterone, DHT, or anabolic steroids. RAD140 demonstrated excellent affinity for the androgen receptor (Ki = 7 nM), higher even than DHT [1]. For reference, the the affinity for the AR for Testosterone in this preclinical model was 29 nM, and 10 nM for DHT. Unlike testosterone and most other androgen receptor mediated anabolic agents, Testolone is orally bioavailable so it does not require injection for proper absorption.

Testolone is a fairly recent SARM; it was developed in 2010 as a possible treatment for osteoporosis. Testing performed on rats and primates has indicated that it may provide additional benefits as well.

In studies, the RAD140 SARM has produced a wide array of effects including:

  • Increased weight loss
  • Increased lean muscle protein synthesis
  • Increased removal of beta amyloid plaques from the brain [2]
  • Increased protection against breast and prostate cancer
  • Increased endurance

However, it must be understood that the Food and Drug Administration (FDA) has not confirmed any health effects of RAD140 for human beings and has not approved it for human use, and the drug should be used for laboratory research purposes only. Anecdotal reports indicate a potential for testosterone suppression in males from RAD 140 administration. There have been a number of studies performed on animals, such as:

  • One study performed on primates, indicated that RAD140 may promote modest increases in lean muscle mass [1].
  • Rat studies showed neuroprotective effects of RAD-140 by activating ARs in the brain, protecting hippocampal neurons from cell death and speeding the clearance of beta amyloid plaques [2]. Another rat study found that RAD140 had neuroprotective benefits of a kind that may prevent Alzheimer’s disease and similar disorders, and may be safer than conventional testosterone therapy [3]. The group treated with 3 mg/kg RAD140 was able to replicate the same level of muscle tissue growth as the group treated with 1 mg/kg Testosterone, with about half of the androgenic activity in the prostate. [3].
  • Androgen therapy has widely been considered in the fight against breast cancer but due to the side effects of anabolic steroids, SARMs like RAD-140 are being considered at this time. In a preclinical study RAD140 significantly suppressed the growth and proliferation of cancer cells in in vivo and in vitro models of AR/ER+ breast cancer [4].

 

Data on our RAD 140 Powder for sale

CAS Number: 1182367-47-0

Formula: C20H16ClN5O2

Molar Mass: 393.83 g/mol

Class: Selective Androgen Receptor Modulator

Half life: 44.7 hours [5]

Experimental Application: Muscle mass and strength gain, improved endurance, improved cognitive function.

Storage: Store in a cool dry place away from direct sunlight to maximize shelf life.

Cited Research: Sports Technology Labs Research Blog

 

  • Foil Pouch with UV resistance to minimize degradation.
  • Minimum 98% pure.
  • 2,050 milligrams RAD 140/Testolone per pouch.
  • Measuring tools not included.

 

This preparation is for laboratory research purposes only and is not approved by the FDA for human consumption. RAD140/Testolone IS NOT A DIETARY OR SPORTS SUPPLEMENT.

 

RAD140 FAQs:

 

Does RAD 140 suppress natural testosterone?

A study performed in 2010 found that After 28 days of dosing with RAD140, the testosterone levels in all three groups was suppressed to approximately 200−300 ng/dL, with similar suppression in all groups, although testosterone levels were significantly different for only the 0.01 mg/kg group (p < 0.05) [6].

Is RAD 140 safe for women?

Although it is not known to be particularly androgenic, there is little available information regarding the safety profile of RAD 140 in women and women should be cautious with participating in clinical research with RAD 140 until more information is available.

Can RAD 140 cause hair loss?

While it is not known to be particularly androgenic on its own, RAD 140 administration can free testosterone that is otherwise bound to SHBG in the male body and this can indirectly increase the risk of hair loss.

 

Why is Sports Technology Labs the best place to buy RAD 140 Powder online?

 

Sports Technology Labs is the best place to buy RAD 140 powder online because of their verifiable, consistent high quality, fast shipping, and their outstanding customer service. The internet seems to be full of sites offering Testolone powder and related substances. This may leave you wondering which of these many options you should select.

Some websites are more interested in making quick cash than in ensuring that their customers receive dependable products. That’s why you need to buy only from websites with established quality-control procedures. When you choose Sports Technology Labs, you are choosing the best place to buy Rad140 powder, from an American company that uses the highest quality U.S.-based third-party labs to test the products and certify a minimum purity of 98%. Our RAD 140 is also available in liquid form.

We are also committed to offering first-rate customer service. You’re always welcome to contact us with any questions or concerns you have about our RAD140 powder for sale.

Abuse Warning

 

RAD 140 is an investigational compound still awaiting FDA approval and is not a dietary supplement. At Sports Technology Labs we are chemical suppliers, not medical doctors, and our expertise is sourcing and quality control. Sports Technology Labs does not encourage or condone consumer use of SARMs products, they are for research purposes only. Anecdotal reports online indicate RAD 140 dosage of 10mg and 20mg per day used by many individuals. A RAD 140 dose of 30mg per day has even been reported by several individuals in online forums. These dosages may not match those used in carefully designed medical research protocols and may pose a serious risk of adverse effects in users.

We consider the duplication of anecdotal protocols online to be a risky practice. SARMs should only be used under the supervision and direction of a medical doctor or designated research authority. We strongly discourage the use of SARMs for performance enhancement in sports and bodybuilding, and warn against “bro science” and peer consensus when making decisions about human health.

 

References:

 

  1. Miller, C. P., Shomali, M., Lyttle, C. R., O’Dea, L. S., Herendeen, H., Gallacher, K., Paquin, D., Compton, D. R., Sahoo, B., Kerrigan, S. A., Burge, M. S., Nickels, M., Green, J. L., Katzenellenbogen, J. A., Tchesnokov, A., & Hattersley, G. (2010). Design, Synthesis, and Preclinical Characterization of the Selective AR Modulator (SARM) RAD140. ACS medicinal chemistry letters, 2(2), 124–129. https://pubs.acs.org/doi/10.1021/ml1002508
  2. Jayaraman, A., Christensen, A., Moser, V. A., Vest, R. S., Miller, C. P., Hattersley, G., & Pike, C. J. (2014). Selective androgen receptor modulator RAD140 is neuroprotective in cultured neurons and kainate-lesioned male rats. Endocrinology155(4), 1398–1406. https://doi.org/10.1210/en.2013-1725
  3. Anusha Jayaraman, Amy Christensen, V. Alexandra Moser, Rebekah S. Vest, Chris P. Miller, Gary Hattersley, Christian J. Pike, Selective AR Modulator RAD140 Is Neuroprotective in Cultured Neurons and Kainate-Lesioned Male Rats, Endocrinology, Volume 155, Issue 4, 1 April 2014, Pages 1398–1406, https://academic.oup.com/endo/article/155/4/1398/2423296
  4. Yu, Ziyang et al. “Selective AR Modulator RAD140 Inhibits the Growth of Androgen/Estrogen Receptor–Positive BC Models with a Distinct Mechanism of Action.” Clinical Cancer Research 23 (2017): 7608 – 7620..
  5. LoRusso P, Hamilton E, Ma C, Vidula N, Bagley RG, Troy S, Annett M, Yu Z, Conlan MG, Weise A. A First-in-Human Phase 1 Study of a Novel Selective AR Modulator (SARM), RAD140, in ER+/HER2- Metastatic Breast Cancer. Clin Br Cancer. 2022 Jan;22(1):67-77. doi: 10.1016/j.clbc.2021.08.003. Epub 2021 Aug 20. PMID: 34565686.
  6. Miller, C. P., Shomali, M., Lyttle, C. R., O’Dea, L. S., Herendeen, H., Gallacher, K., Paquin, D., Compton, D. R., Sahoo, B., Kerrigan, S. A., Burge, M. S., Nickels, M., Green, J. L., Katzenellenbogen, J. A., Tchesnokov, A., & Hattersley, G. (2010). Design, Synthesis, and Preclinical Characterization of the Selective Androgen Receptor Modulator (SARM) RAD140. ACS medicinal chemistry letters2(2), 124–129 https://doi.org/10.1021/ml1002508
RAD 140 Powder (Testolone) | 2 Grams

Additional information

Weight 0.25 oz
Dimensions 3 × 0.3 × 4 in