LGD-4033, commonly referred to as Ligandrol, is a third-generation non-steroidal oral SARM that possesses a strong affinity for the androgen receptor, with a Ki of approximately 1 nM. It ranks as the second most sought-after SARM in the market today.
Unlike testosterone, which produces anabolic effects via the same pathway, LGD-4033 selectively binds to receptors in skeletal muscle, bone, and connective tissue, with very little affinity for receptors in the prostate, scalp, and skin.
Developed by Ligand Pharmaceuticals, it was designed to address conditions such as muscle atrophy and osteoporosis, without the virilizing consequences that come with anabolic steroids. LGD-4033 is available for purchase online at Sports Technology Labs, considered the premium source.
In preclinical studies involving primates, LGD-4033 displayed a substantial dose-dependent enhancement in lean body mass for both male and female monkeys over a 13-week dosage period at levels of 0.6, 3, 15, or 75 MG/KG of bodyweight.
Moreover, 70% of the gained body mass was maintained after a 4-week recovery phase. Treatment was discontinued at 48 days in the 75mg/kg group due to toxicity, a dose far greater than the maximum amount used in clinical trials (0.5, 1, and 2mg in total administered to subjects).
A Phase 1 clinical trial conducted with 76 adult male participants who were orally given LGD-4033 in different doses indicated a dose-dependent augmentation in lean body mass, with all 76 subjects tolerating the drug well over a 21-day period.
In Phase 2 clinical trials involving 120 patients recuperating from hip fracture surgery, participants were assigned either a placebo or doses of 0.5, 1, or 2mg LGD-4033 for 12 weeks. The results showed that LGD-4033 led to significant increases in total lean body mass, along with dose-dependent reductions in average fat mass.
Additionally, subjects who received LGD-4033 experienced enhancements in serum procollagen type 1 propeptide (s-P1NP), an indicator of bone anabolism, and demonstrated improvements in a 6-minute walk distance compared to those on a placebo.
No significant negative effects were noted in any of the study’s groups. An assessment conducted 12 weeks post-trial found that participants retained the muscle mass they had acquired from the treatment.
CAS Number: 1165910-22-4
Molar Mass: 338.258 g/mol
Half life: 24 – 36 hours
Class: Selective Androgen Receptor Modulator
Storage: Store in a cool dry place away from direct sunlight to maximize shelf life.
This preparation is for laboratory research purposes only and is not approved by the FDA for human use. Ligandrol/LGD-4033 IS NOT A DIETARY OR SPORTS SUPPLEMENT.
If you’re trying to figure out where to buy SARMs powder online, there certainly seem to be plenty of choices out there but Sports Technology Labs is the best place to buy LGD 4033 powder online. Not all companies offering LGD4033 powder for sale are alike—or equally trustworthy.
To buy LGD4033 powder from a randomly selected website is dangerous, even if the price looks reasonable, because you just can not be certain about their quality-control processes.
At Sports Technology Labs, however, you can find the highest quality LGD4033 powder for sale anywhere on the internet. We’re an American business and our products are tested in U.S.-based third-party laboratories that certify minimum 98% purity. That’s why we’re confident in our claim that we offer the best Ligandrol powder for sale on the market today.
We offer free shipping on orders over $149 and if you need the products in a hurry we offer express shipping as well. Customers that sign up for our email list get 10% off, and an additional 10% off for payment with cryptocurrency.
Our LGD-4033 is also available in liquid form. If you have any questions about our Ligandrol powder products, you can also contact us and we’ll respond as soon as possible.
LGD 4033 is an investigational compound still awaiting FDA approval and is not a dietary supplement. At Sports Technology Labs we are chemical suppliers, not medical doctors, and our expertise is sourcing and quality control. Sports Technology Labs does not encourage or condone consumer use of SARMs products, they are for research purposes only.
SARMs should only be used under the supervision and direction of a medical doctor or designated research authority. We strongly discourage the use of SARMs for performance enhancement in sports and bodybuilding, and warn against “bro science” and peer consensus when making decisions about health.
Yes, LGD4033 is the strongest SARM when tested on a per milligram basis.
To date there are no studies suggesting gynecomastia from LGD4033 administration in animal studies.
Yes, LGD4033 can suppress natural testosterone levels in male test subjects.
1. Basaria et al. The Safety, Pharmacokinetics, and Effects of LGD-4033, a Novel Nonsteroidal Oral, Selective Androgen Receptor Modulator, in Healthy Young Men. The Journals of Gerontology: Series A, Volume 68, Issue 1, January 2013, Pages 87–95.
2. Fragkaki et al. Human in vivo metabolism study of LGD-4033. Drug Test Analysis. Drug Test Anal. 2018 Nov;10(11-12):1635-1645. doi: 10.1002/dta.2512. Epub 2018 Nov 8.
3. “Viking Therapeutics Initiates Phase 2 Trial of VK5211 in Patients Recovering From Hip Fracture.” FierceBiotech. Questex LLC, 03 Nov. 2015. Web. 21 Nov. 2016.