Selective androgen receptor modulators or SARMs have sparked a lot of conversation over the past few years. While there might be some controversy surrounding SARMs, the fact remains that there is a lot of research still happening to fully understand the potential benefits of taking SARMs.
If you’re seeking to understand the SARMs research that has been released recently, this information is for you. Keep reading for an overview of recent research and what it means for SARMs.
SARMs Research and Cancer
There have been a few studies over the past year that have looked at SARMs and their potential for use in the treatment of cancer. The types of cancer that SARMs could potentially treat have varied.
One study done in 2021 looked at SARMs’ benefits in the treatment of breast cancer. The results of this study have preliminary findings that could be promising.
This study looked at patients with metastatic breast cancer. This study is a phase 1 study, and this was the first human study.
The goal of this study was to characterize the following factors when it came to an oral selective androgen receptor modulator called RAD140:
- Maximum tolerated dose
- Pharmacokinetic profile
- Antitumor activity
The study utilized women who were postmenopausal with ER+/HER2- metastatic breast cancer.
From this study, it was concluded that RAD140 has an acceptable safety profile. In addition, there there is preliminary evidence of antitumor activity and target engagement.
This 2021 study looked at the role of SARMs in suppressing tumor growth in individuals with prostate cancer. Studies in the past have noted that high concentrations of activating ligands testosterone can suppress the growth of prostate cancer cells.
The goal of this study was to determine if nonsteroidal and orally bioavailable SARMs could achieve the same effect. This study was conducted both in vitro and in vivo.
The study found that the administration of SARMs did, in fact, suppress the growth of prostate cancer cells. The comparison to steroidal androgens was favorable.
Due to the fact that SARMs have already been tested in various clinical settings for other health conditions, the potential for accelerating them as a prostate cancer therapy and implementing them, is available.
The current study supports more exploration in using SARMs to treat prostate cancer. Since SARMs have a favorable safety profile, the potential to improve general health, and a convenient method of delivery, researchers believe they are an attractive option.
SARMs and Other Medical Conditions
Further studies have looked even more closely at the use of SARMs when it comes to a variety of medical conditions. These studies continue to explore the potential uses of SARMs to treat a variety of ailments.
Stress Urinary Incontinence
A study on SARMs and stress urinary incontinence was completed utilizing rats. Specifically, the SARM, GSK2849446A, was utilized.
Researchers looked at urethral continence function during a sneeze reflex. Female rats were used that had an ovariectomy-induced estrogen deficiency.
The results of this study were favorable. It was found that SARMS could treat stress urinary incontinence without affecting the function of the bladder.
It does this by enhancing striated and smooth muscle-mediated urethral functions during conditions that cause stress, like sneezing.
Sarcopenia is a degenerative disease where individuals affected lose muscle mass over time. This can lead to muscle dysfunction and muscle strength.
Sarcopenia is generally present in elderly individuals and can impact their quality of life. A study in 2021 looked at multiple modes of treatment and how they could aid individuals with sarcopenia.
SARMs are one method of treatment that was explored. Because SARMs have significant anabolic activity in bone and muscle, but moderate to minimal androgenic side effects, there are a few SARMs that have the potential to treat sarcopenia.
Some of the SARMs in question include:
SARMs Research and Safety
One of the more controversial topics when it comes to SARMs is their safety. While some may encourage SARMs for bodybuilding, and you can find a lot of information about SARMs online, are they safe?
In addition, does it matter where you buy SARMs from? Some of this SARMs research looked at the answers to questions people may have on the safety of SARMs.
When you buy SARMs, you want to know that they are properly labeled and will give you the benefits you want. One study took the time to look at various SARMs available to get purchased in the UK and their labeling.
They took 20 different products and explored whether the reported ingredients were consistent with what was actually found in the bottle. For many bottles, they found that not only were ingredients that were reported to be present not there but there were extra ingredients that were not listed on the label.
For example, one bottle listed the ingredients as RAD-140 and Ibutamoren. However, when tested, the capsules did not contain RAD-140, and they did contain YK-11, which was not listed.
Only six of the SARMs out of 20 actually contained the ingredient they reported and nothing else. If you buy SARMs, buying them from a trusted source is imperative.
If not, you might not actually know what you are putting in your body.
Explore More SARMs Research
The SARMs research listed above are just a few in comparison to the vast amount of research that is still getting completed about SARMs. Take the time to educate yourself and arm yourself with the knowledge you need.
Sports Technology Labs provides products that are high quality and get tested by a third party for 98 percent purity. Contact us today to discuss SARMs and find out the many benefits of purchasing through us.
1. A First-in-Human Phase 1 Study of a Novel Selective Androgen Receptor Modulator (SARM), RAD140, in ER+/HER2- Metastatic Breast Cancer – PubMed (nih.gov) pubmed.ncbi.nlm.nih.gov/34565686/
2. JCI – Selective androgen receptor modulators activate the canonical prostate cancer androgen receptor program and repress cancer growth www.jci.org/articles/view/146777#top
3. Effects of a Selective Androgen Receptor Modulator (SARM), GSK2849446A, on Stress Urinary Incontinence and Bladder Activity in Rats with Ovariectomy-induced Estrogen Deficiency (nih.gov) www.ncbi.nlm.nih.gov/pmc/articles/PMC7261644/
4. Advances in research on pharmacotherapy of sarcopenia (nih.gov) www.ncbi.nlm.nih.gov/pmc/articles/PMC8444957/
5. Analysis of supplements available to UK consumers purporting to contain selective androgen receptor modulators analyticalsciencejournals.onlinelibrary.wiley.com/doi/epdf/10.1002/dta.2908