How do SARMs Work – The Definitive Guide

how do sarms work

Have you wondered how do SARMs work and how can you begin researching their effects? 

To get started with SARMs research, it helps to understand their basic effects on receptors. SARMs may hold the key to future treatments for cancer, muscle wasting, and much more. 

Although they have become tainted through unregulated use and counterfiet sales online, this does not negate the need for high-quality research. If you have an interest in how SARMs function and how quickly do SARMs work, we have a complete guide for you. 

In our article, we will talk about what SARMs are, how they work, and where current studies are at. Keep reading on for more information!

What Are SARMs?

What does SARMs stand for? The acronym stands for Selective Androgen Receptor Modulators. They are not the same compounds as androgenic steroids. 

Instead, SARMs bind to androgen receptors selectively and trigger anabolic activity. Unlike anabolic steroids, the current research shows fewer androgenic side effects, improved selectivity, and reduced estrogen conversion. 

There are several types of SARMs, characterized by their name and a string of letters and numbers. Some of the more common SARMs you may read about include:

  • Ostarine (MK-2866)
  • Ligandrol (LGD-4033)
  • Testolone (RAD-140)
  • Andarine (S-4)

One of the most prevalent SARMs is ostarine or mk2866. Some of the properties that differentiate SARMs are their specific agonistic and antagonistic effects on androgen receptors. 

For example, current studies show that ostarine has similar anabolic effects as testosterone. Some of ostarine’s effects based on controlled research groups include:

  • Prostate growth
  • Lean body mass
  • Maintaining libido

However, unlike steroidal drugs, SARMs do not have clearance for human consumption. Research is in its infancy, and dosages, side effects, and applications are still going through animal and early human trials. 

How Do SARMs Work?

SARMs function as agonists and antagonists on androgen receptors. SARMs are not naturally occurring chemicals. Rather, they are chemically engineered products with tissue-specific functions resulting in a myriad of actions. These are novel drugs that demonstrate some promise for improved androgen treatments in the future. 

You can find androgen receptors in many types of tissue outside reproductive organs. These receptors are primarily responsible for male sexual development but are also found in females. 

There are several limitations with testosterone hormone replacement that spurred SARMs research. For example, virilization side effects or thattestosterone and most androgen therapies lack an oral format and are primarily distributed via injection. SARMs have several risks for human consumption, including:

  • Testicular atrophy
  • Dyslipidemia
  • Gynecomastia
  • Hepatotoxicity

As SARMs bind to receptors and activate specific cellular functions, they are not metabolized to dihydrotestosterone (DHT) or estrogen. This limits androgenic and estrogenic side effects. 

Current SARMs Findings

Most researchers understand how SARMs can alter receptors targeting bone and muscle growth. However, there are several other potential benefits revolving around their tissue-specificity functions. 

Recent Phase 1 clinical trials found RAD-140 had an acceptable safety profile for antitumor activity in patients with metastatic breast cancer. Additionally, prostate cancer groups also showed preliminary data suggesting a safe, alternative treatment. SARMs are also undergoing or have completed early trials for:

  • Stress urinary incontinence
  • Sarcopenia
  • Lung cancer
  • Alzheimer’s disease
  • Metabolism

Long-term effects are largely unknown. Many trials have not surpassed Phase II clinical trials, limiting information regarding efficacy. Some common side effects seen in trials are headache, nausea, and muscle pain.

How Do You Take SARMs?

SARMs are not indicated for human consumption. For clinical research, powder and liquids are more appropriate than capsules. 

Liquids and powders have more consistent and reliable purity ratings if manufactured in reliable facilities. Third-party testing facilities can measure SARMs purity against reference standards.

These procedures help to ensure you receive quality batches. How researchers administer SARMs may vary. A recently completed Phase II clinical trial focused on GSK2881078. 

This SARM was used for COPD and administered in an oral form. One of the primary reasons SARMs are being studied is their oral administration. If there is an easy way to promote SARMs’ benefits through oral administration, it could broaden androgen therapy. 

How Well Do SARMs Work?

Some questions also center around “how fast do SARMs work?” Unfortunately, many of the results people turn toward are unreliable internet sources. Although SARMs are not FDA-approved for human use, that hasn’t stopped people from purchasing them for individual consumption. 

This has altered reliability of anecdotal results and increased the risk for toxicity. This was evident in a recent case study. A 32-year-old male consumed ligandrol without medical monitoring for two weeks. 

In clinical trials, researchers have only used 0.1 mg to 1 mg dosages slowly administered over 21 days. While the patient demonstrated hepatotoxicity concerns, clinical trial participants had no significant adverse effects. 

From this information, you could draw the conclusion that researchers expect effects begin within 14 to 21 days. Yet, there is not enough comprehensive and reliable research to conclude how fast and well SARMs work. 

Your Next SARMs Research

How do SARMs work? SARMs are similar to testosterone and other androgen therapies. Yet, they could hold the key to fewer side effects and more options for treatment. 

Since answering the questions surrounding SARMs and how do they work is still in its infancy, now is the time to start your research. For the highest quality results, you need a reliable SARMs supplier. 

At Sports Technology Labs, we sell SARMs liquids and powders for various research institutes. Our batches are consistently tested against minimal standard qualities. Contact Sports Technology Labs today and find out more about SARM’s research potential! 

References

Barbara, M., Dhingra, S., & Mindikoglu, A. L. (2020, June 11). Ligandrol (LGD-4033)-Induced Liver Injury. ACG case reports journal. Retrieved July 14, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7304490/

Burmeister, M. A., Fincher, T. K., & Graham, W. H. (2020, June 18). Recreational Use of Selective Androgen Receptor Modulators. U.S. Pharmacist – The Leading Journal in Pharmacy. Retrieved July 14, 2022, from https://www.uspharmacist.com/article/recreational-use-of-selective-androgen-receptor-modulators

Christiansen, A. R., Lipshultz, L. I., Hotaling, J. M., & Pastuszak, A. W. (2020, March). Selective androgen receptor modulators: The future of Androgen therapy? Translational andrology and urology. Retrieved July 14, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7108998/

COA’s. Sports Technology Labs. (2022, June 30). Retrieved July 14, 2022, from https://sportstechnologylabs.com/coas/

Contact. Sports Technology Labs. (2022, May 7). Retrieved July 14, 2022, from https://sportstechnologylabs.com/contact/

Kirksey, C. (2022, January 25). Your Ultimate 2021 SARMs Research Review. Sports Technology Labs. Retrieved July 14, 2022, from https://sportstechnologylabs.com/sarms-research/

Sports Technology Labs. (2022, May 14). Effects of Ostarine on Muscle Tissue. Sports Technology Labs. Retrieved July 14, 2022, from https://sportstechnologylabs.com/ostarine/

Study to evaluate the safety and efficacy of 13 weeks of the selective androgen receptor modulator (SARM) GSK2881078 in chronic obstructive pulmonary disease (COPD) – full text view. Full Text View – ClinicalTrials.gov. (n.d.). Retrieved July 14, 2022, from https://clinicaltrials.gov/ct2/show/NCT03359473

Trends, charts, and maps. ClinicalTrials.gov. (2021, March). Retrieved July 14, 2022, from https://www.clinicaltrials.gov/ct2/resources/trends

U.S. National Library of Medicine. (n.d.). Enobosarm. National Center for Biotechnology Information. PubChem Compound Database. Retrieved July 14, 2022, from https://pubchem.ncbi.nlm.nih.gov/compound/Enobosarm#section=MeSH-Tree

How do SARMs Work – The Definitive Guide