SR9009 and Cardarine are investigative nonsteroidal compounds of great interest to researchers because of their potential properties. The two are often lumped together with a class of compounds called Selective Androgen Receptor Modulators (SARMS) that have a different safety margin than steroids because of their selectivity for androgen receptors.
Preliminary research in mammals has shown the potential of SR9009 in inducing wakefulness, increasing metabolism, and promoting muscle recovery [1,2]. Similar research has also demonstrated the potential of cardarine in improving insulin sensitivity and thereby reducing body fat, improving endurance for physical training, and correcting fatty acid imbalances [3,4,6].
Research into these compounds is limited so far, and like other SARMS for sale, the Food and Drug Administration (FDA) hasn’t approved either for human consumption.
Both compounds are banned from many major sports leagues and sporting communities. Athletes should not participate in research or clinical trials with these products as they are for laboratory use only and tested for by most athletic leagues.
Both are listed on the World Anti Doping Agency (WADA) list of prohibited substances and considered as class S4 compounds “hormone and metabolic modulators.“
This article describes the properties, effects, benefits, and side effects of the two compounds. It will also answer another question: Are they even SARMs?
What Is SR9009?
SR9009, also known as Stenabolic, is not a “real” SARM, though it is often mistaken as one. It is instead a type of nootropic called REV-ERB agonists . REV-ERB proteins are found in the liver, muscles, and other areas of the body, and they promote wakefulness when there is a sleep pathology .
REV-ERB proteins have also shown potential in reducing the risk of atherosclerosis in mouse models . In vivo and in vitro studies have demonstrated SR9009’s potential in modulating different factors that help to build endurance for physical activity .
What Is Cardarine?
Cardarine, also known as GW501516, is not a “real” SARM, even though it’s marketed as such. It has a high affinity for peroxisome proliferator-activated receptors (PPARs) with selectivity for PPARα and PPARγ . It was developed by Ligand Pharmaceuticals working in collaboration with GlaxoSmithKline, with an intention to investigate its potential effects on obesity, dyslipidemias, diabetes, and cardiovascular disease . Monkey studies have demonstrated Cardarine’s potential in improving cardiovascular function .
The Major Differences Between SR9009 Vs. Cardarine
The FDA considers SR9009 and Cardarine investigational compounds and has not approved them as supplements. Researchers continue to explore the properties of these two compounds, which appear to be quite similar. They have several differences that make their applications quite different, though, including:
- The half-life of Cardarine is 24 hours, while that of SR9009 is four to five hours. This means Stenabolic is eliminated from the body much faster.
- Cardarine has been studied more than Stenabolic and is currently in phase II clinical trials. No human trials have been performed with SR9009 [1,2].
- Cardarine is a PPAR agonist, while Stenabolic is a REV-ERB agonist [2,3].
- Both compounds may help to build endurance, but Cardarine appears to have greater potential in this area according to research.
- Cardarine is more potent on a per milligram basis.
- Stenabolic is more expensive than Cardarine.
- Cardarine has more potent anti-inflammatory capabilities .
The points above demonstrate how different the two compounds are. Researchers will hopefully learn more about these compounds as their studies continue, but some possible side effects have already been noted.
Potential Side Effects Under Study with SR9009 Vs. Cardarine
Potentially Serious Side Effects
A lab study showed that a high amount of Cardarine could increase cancer risk; this is also possible with similar anabolic agents .
Long-Term Effects Are Unknown
It’s difficult to ascertain the full extent of the possible adverse events linked to the testing of these compounds because research is very limited in this area. Preliminary investigations have shown a modest safety profile at appropriate quantities, though in rat studies .
Please note that neither of these products are meant for human consumption and both are banned in numerous athletic leagues. Athletes should not participate in clinical research with either product.
Benefits of SR9009 Under Study
Stenabolic demonstrates a key role in regulating the body’s internal clock and in glucose and lipid metabolism. Researchers are interested in the potential of Stenabolic in the following areas:
- Effect on wakefulness in pathological conditions that affect sleep 
- Effect on fat storage by inducing the oxidation of fatty acids and glucose 
- Energy and endurance 
- Effect on connective tissue 
- Atherosclerosis 
No human trials have been conducted on SR9009 so far, so researchers have more to learn. Preliminary research has found significant potential in such areas as regulating the circadian rhythm.
Potential Benefits of Cardarine
Cardarine has shown the ability to facilitate energy production and fatty acid metabolism during exercise . This makes it a potential candidate for treating metabolism-related conditions such as diabetes and obesity . Researchers are looking into the potential of GW501516 in other areas including the effects on:
- decreasing or increasing endurance for physical activity
- worsening or improving insulin sensitivity
- worsening or accelerating bodyfat loss 
- Balancing HDL/LDL/Triglycerides 
The results of ongoing phase II clinical trials will help shed light on the potential (obesity, diabetes, and cardiovascular disease) of Cardarine.
Preliminary research suggests that both compounds have potential benefits, but they may also have some risks that need to be addressed adequately. It’s important to approach these compounds with caution as long as they lack FDA approval.
Researchers are free to purchase these compounds in their chemical form for research use, however. It’s essential to deal with a trusted supplier who can provide third-party results to confirm that the products meet the standard of 98% purity set by researchers.
Visit the Sports Technology Labs Blog for News and Information About SARMs
For the highest quality RAD 140, Ligandrol, Ostarine, MK 677, and other SARMs for sale, look no further than Sports Technology Labs. Visit the Sports Technology Labs research blog for information about new products, updates in the industry, side effects, new scientific literature, and product comparisons.
- Geldof, L., Deventer, K., Roels, K., Tudela, E., & Van Eeno, P. (2016). In Vitro Metabolic Studies of REV-ERB Agonists SR9009 and SR9011. International journal of molecular sciences, 17(10), 1676.
- Sitaula, Sadichha et al. “Suppression of Atherosclerosis by Synthetic REV-ERB Agonist.” Biochemical and biophysical research communications 460.3 (2015):566–571.
- Oliver WR, Shenk JL, Snaith MR, Russell CS, Plunket KD, Bodkin NL, Lewis MC, Winegar DA, Sznaidman ML, Lambert MH, Xu HE, Sternbach DD, Kliewer SA, Hansen BC, Willson TM (April 2001). “A selective peroxisome proliferator-activated receptor delta agonist promotes reverse cholesterol transport”. Proc. Natl. Acad. Sci. U.S.A. 98 (9): 5306–11. doi:10.1073/pnas.091021198. PMC 33205. PMID 11309497.
- “GW501516 Glaxo Welcome phase change I, UK”. R & D Focus Drug News. 20 November 2000.
- Sprecher DL (December 2007). “Lipids, lipoproteins, and peroxisome proliferator activated receptor-delta”. Am. J. Cardiol. 100 (11 A): n20–4.
- Geiger LE, Dunsford WS, Lewis DJ, Brennan C, Liu KC, Newsholme SJ (2009). PS 895 – Rat carcinogenicity study with GW501516, a PPAR delta agonist (PDF). 48th Annual Meeting of the Society of Toxicology. Baltimore: Society of Toxicology. p. 105. Archived from the original (PDF) on 2015-05-04.5.
- Thevis M, Geyer H, Thomas A, Schänzer W (May 2011). “Trafficking of drug candidates relevant for sports drug testing: detection of non-approved therapeutics categorized as anabolic and gene doping agents in products distributed via the Internet”. Drug Test Anal. 3 (5): 331–6. doi:10.1002/dta.283. PMID 21538997.