Selective androgen receptor modulators (SARMs) are an emerging class of compounds that are becoming an attraction for researchers due to their perceived potential. SARMs are ligands of androgen receptors (ARs) and therefore have anabolic properties similar to those produced by anabolic steroids.
Many people often mistake SARMs for steroids due to their similar actions on the androgen receptor(s). This article demystifies them by first explaining the science behind SARMs and busting 7 common SARMs myths. So what are SARMs and why do so many researchers choose to buy RAD 140 instead of older more researched anabolic compounds?
SARMs: What Are SARMs?
Selective androgen receptor modulators, SARMs are synthetically engineered to produce specific targeted effects in the body and are currently approved as investigational compounds in the U.S.
Potential uses of SARMs in sports medicine or therapeutic uses are being researched but have not yet been FDA approved. These products marketed as dietary supplements are false advertisements and are not approved by the FDA.
The Science Behind SARMs
Information on SARMs with scientific backing is scant. Researchers have yet to fully grasp how the different kinds interact within the body and the effects expected from each class. Here are three things to help you understand SARMs, based on preliminary studies.
SARMs and the Androgen Receptor (S)
SARMs are ligands of the AR. This class of compounds interacts with ARs both as agonists and antagonists “selectively.” The selective action differentiates them from steroids.
SARMs are engineered to target androgen receptor (s) in specific tissues and avoid the rest. This enhances their action while limiting adverse effects. They may target androgen receptor (s) in the muscles, for example, that show effects on fat mass, muscle mass, and bone density.
SARMs may avoid or even behave antagonistically in androgen receptor (s) in the prostate and consequently mitigate prostate enlargement. Studies surrounding SARMs and prostate cancer are underway.
Benefits Researchers Are Studying
A list of SARMs benefits are being investigated by researchers. In research, their anabolic properties (increase muscle mass and effect on muscle wasting diseases) have been of particular interest as they may improve tissue healing and muscle mass in those suffering from cancer Cachexia.
One preliminary study showed that SARMs (RAD 140) have anti-tumor activity against metastatic breast cancer. Researchers are also looking at the potential benefits of treating the following conditions:
A 2019 meta-analysis demonstrated the vast corrective potential of SARMs and their ability to revolutionize the medical treatment of several debilitating conditions.
Most studies on SARMs have yet to pass phase two clinical trials, so the long-term effects are also unknown. More research must be conducted on the above, as well as how SARMs affect skeletal muscle in the future.
Research has shown that SARMs may cause several unwanted side effects in spite of their selective action. Some of the known side effects include:
- Back pain
- Stomach pain
- Water retention
- Decreased sexual drive
- Reduction in testosterone levels in males
- Liver injury and liver toxicity
- Increased hematocrit
These side effects may not be as adverse as those caused by steroids, but they are significant nonetheless.
7 SARMs Myths
A lot has been said about SARMs, though the science behind SARMs remains few and far between. This knowledge gap has created the perfect environment for rumors and myths to marinate. Here are seven popular myths we’d like to bust.
Myth 1: They Are Illegal
SARMs are considered investigational compounds in the U.S. and are therefore legal for research. SARMs are unapproved for several indications and are not dietary supplements, but they are not illegal.
Myth 2: They Can Be Used in Sports
The use of SARMs in sports is unapproved, even though research shows significant potential in this area. Research indicates they may promote the growth of lean muscle mass without triggering concurrent growth of fat mass.
However, the world anti-doping agency currently bans them. Competitive athletes should not engage in research with SARMs as this is prohibited. The half-life varies amongst these compounds and each will be tested for in competitive sports.
Myth 3: They Are Steroids
When you Google Selective androgen receptor modulators SARMs, you will likely see several results on steroids popping up. This is because the two classes of compounds have several similarities stemming from their relationship with androgen receptors.
Both SARMs and steroids have anabolic properties and are therefore sought after, but SARMs are not steroids, and the two terms cannot be used interchangeably.
Myth 4: They Are Supplements
Supplements are natural or synthetic compounds manufactured as nutrients to supplement one’s diet. SARMs do not fit this description; therefore, they are not supplements.
Dietary supplement product labels provide different information than SARMs labels. They cannot be used to supplement one’s diet, nor have they received FDA approval as supplements.
Myth 5: They Are More Harmful than Steroids
Unlike steroids, SARMs are not broken down into dihydrotestosterone and estrogen when metabolized, reducing their “masculinizing” and “feminizing” side effects.
Myth 6: They All Work the Same Way
SARMs exert anabolic effects through their interaction with androgen receptors. However, the action is different for each type of SARM. For example, Stenabolic (SR9009) is an agonist of the REV-ERB protein, while Cardarine (GW501516) is an agonist of the peroxisome proliferator-activated receptor (PPAR).
Myth 7: SARMs Are FDA Approved
The FDA does not approve SARMs as supplements. These are chemicals for research use only. More clinical research needs to be carried out before they can be subjected to the FDA approval process.
The FDA recently issued a statement warning the public about some risks associated with SARMs. The FDA has also approved some anabolic steroids, which can be purchased with a doctor’s prescription.
These myths have led to a gross misunderstanding of the uses, benefits, harmful effects, and legality of SARMs. SARMs research is ongoing and more research must be conducted in order to shed light on how SARMs affect various parts of the body including skeletal muscle.
Can You Buy Them Online?
You can buy SARMs online if you’re conducting research on them. There is a need for some due diligence because many SARMs vendors are disreputable. When purchasing SARMs, you should stay away from vendors that don’t have certificate of analysis (COA) reports available upon request.
A recent study published in the Journal of the American Medical Association highlighted the high affinity of counterfeit selective androgen receptor modulators in the market, so it’s crucial to check sellers for the above qualifications.
Ensure the products contained in the bottle are what is actually on the label by checking and verifying COA’s. A complete list of COA’s should be available on every seller’s site.
Visit the Sports Technology Labs Blog for News and Information about SARMs
Look no further than Sports Technology Labs for the highest quality RAD 140, Ostarine, MK 677, and other SARMs for sale. Visit the Sports Technology Labs research blog for information about new products, updates in the industry, side effects, recent scientific literature, and product comparisons.
1. Basaria S, Collins L, Dillon EL, Orwoll K, Storer TW, Miciek R, Ulloor J, Zhang A, Eder R, Zientek H, Gordon G, Kazmi S, Sheffield-Moore M, Bhasin S. The safety, pharmacokinetics, and effects of LGD-4033, a novel nonsteroidal oral, selective androgen receptor modulator, in healthy young men. J Gerontol A Biol Sci Med Sci. 2013 Jan;68(1):87–95. doi: 10.1093/gerona/gls078. Epub 2012 Mar 28. PMID: 22459616; PMCID: PMC4111291.
2. Crawford J, Prado CM, Johnston MA, Gralla RJ, Taylor RP, Hancock ML, Dalton JT. Study Design and Rationale for the Phase 3 Clinical Development Program of Enobosarm, a Selective Androgen Receptor Modulator, for the Prevention and Treatment of Muscle Wasting in Cancer Patients (POWER Trials). Curr Oncol Rep. 2016 Jun;18(6):37. doi: 10.1007/s11912-016-0522-0. Review.
3. Jayaraman A, Christensen A, Moser VA, Vest RS, Miller CP, Hattersley G, Pike CJ. Selective androgen receptor modulator RAD140 is neuroprotective in cultured neurons and kainate-lesioned male rats. Endocrinology. 2014 Apr;155(4):1398-406. doi: 10.1210/en.2013-1725. Epub 2014 Jan 15. PMID: 24428527; PMCID: PMC3959610.
4. Solomon ZJ, Mirabal JR, Mazur DJ, Kohn TP, Lipshultz LI, Pastuszak AW. Selective Androgen Receptor Modulators: Current Knowledge and Clinical Applications. Sex Med Rev. 2019 Jan;7(1):84-94. doi: 10.1016/j.sxmr.2018.09.006. Epub 2018 Nov 30. PMID: 30503797; PMCID: PMC6326857.
5. Christiansen AR, Lipshultz LI, Hotaling JM, Pastuszak AW. Selective androgen receptor modulators: the future of androgen therapy? Transl Androl Urol. 2020 Mar;9(Suppl 2):S135-S148. doi: 10.21037/tau.2019.11.02. PMID: 32257854; PMCID: PMC7108998.