What does Andarine Do?

what does andarine do?

What Does Andarine Do


Research is continuously conducted on various chemical substances and compounds to find their use. Synthetic androgen receptor ligands are also such chemical compounds which are under clinical research, the first of which was developed is Andarine.


You would have heard of Andarine before, but you must be wondering ‘what does Andarine do?’. Read on to discover what Andarine does and what kind of impact it has on the androgen receptor.

What Is Andarine?


Andarine is a selective androgen receptor modulator, also known as a SARM. It is an investigational drug not yet legalized by the Food and Drug Administration (FDA). Currently, it is placed on the dietary supplement advisory list by the FDA.

What Does Andarine Do?


Andarine is one of the most potent and effective research chemicals for fat loss with great visible results.


This potent SARM was initially introduced to treat musculoskeletal disorders such as muscle waste and bone loss in diseases like cancer and HIV. After that, researchers identified the potential of this SARM to eliminate fat tissue in the body.

Significant gains in lean body mass are expected with the combination of Andarine and an effective diet and training regiment.

How Does Andarine Work?

Andarine is a non-steroid SARM that binds itself to the androgen receptors in muscle, bone, and body fat tissues. This process enables increased protein synthesis, stimulates osteoblasts, decreases glucose uptake into cells, promotes blood vessel formation, and reduces body fat.


These features of Andarine help muscles grow quickly without many of the typical side effects associated with administration of harmful steroids, insulin, or other muscle growth hormones.


Andarine also stimulates the bones to increase in strength and density. In theory, this SARM must be paired with effective workout sessions to gain the above adaptive benefits. 

Benefits Of Using Andarine for Research


There are many benefits observed in clinical research with the administration of Andarine.


  • It may increase muscle mass and strength without coadministration with other drugs or hormones.

  • It may increase bone density, which benefits those suffering from diseases that lead to bone loss and muscle waste, such as osteoporosis.

  • It has displayed therapeutic effects on diseases such as cancer and AIDS, which cause muscle waste.

  • It may increase power and strength, which is beneficial for researchers.

  • It increases the number of blood vessels in adipose tissue which contributes to greater circulation and a potential decrease in cellulite.

  • It has fat-burning properties.

  • It displayed effectiveness in cutting body fat, bulking, and body recomposition.


Why Perform Research with Andarine As A Choice Of SARM


Andarine is the oldest SARM and is considered one of the best SARMs for cutting body fat as it helps the human body shred fat while supporting muscle growth, and it does this by improving blood circulation to the muscles and stimulating protein synthesis within muscle cells via the androgen receptor. Andarine is not known to cause virilization or feminization, unlike most anabolic steroids.


Andarine is also a common addition to bulking and cutting stacks to enhance their results, and it may help reduce oxidative stress and create faster fat-burning results. Performance, endurance, and stamina may also improve with the use of Andarine. 


Andarine does not produce progestogenic or estrogenic effects as most conventional steroids do.


All of the above reasons make Andarine one of the best choices for SARM.

Downside Of Using Andarine for Research


Andarine is believed to have fewer risks than using steroids for muscle mass gain. However, it still has side effects, and its warning and precautions must be taken seriously.

Andarine Side Effects


Below are the potential side effects observed in test subjects using Andarine:


  • It may cause an increase in prolactin hormone leading to gynecomastia. More severe cases could lead to liver damage in specific individuals. [1]

  • It may cause an increase in LDL cholesterol levels and a decrease in HDL cholesterol levels, which increases the risk of cardiovascular disease and stroke.

  • It may suppress natural testosterone levels in males.

  • It may cause acne breakouts due to hormone imbalance.

  • It may cause dry mouth and lips.

  • It may cause irritability and mood swings.

  • It could cause a temporary yellow tint to vision and a reduction in night vision. This is considered by researchers to be a benign side effect that occurs at high doses.


Andarine Precautions And Warnings


Use of Andarine, especially in high doses over a long period, has been linked to liver damage and heart disease. Individuals must consult their doctor before participating in research with Andarine.


Individuals with specific health conditions should not take Andarine; more on that later. There is also no evidence of its safety for consumption during pregnancy and breastfeeding. So, it is always advised for pregnant women to avoid participating in clinical research with Andarine. 

The interaction of Andarine with other drugs is still not clear. Therefore, individuals performing research with Andarine must consult their healthcare practitioner regarding potential drug interactions.

How To Use Andarine


Inappropriate use of Andarine could lead to serious health issues. Therefore, you must know how to use Andarine and understand that at this time there are no recommended dosages by the FDA.


Andarine Dosage


The optimal Andarine dosage that is suitable for any individual needs to be determined by a healthcare practitioner and is not determined by the FDA at this time. Andarine dosing is directly linked with its side effects, and a higher dosage could lead to more severe side effects. Anecdotal reports indicate dose dependent benign and temporary visual disturbances.


Factors That Affect Andarine Dosage


Several factors affect the efficacy of a selected Andarine dosage.


  • General health condition

  • Age

  • Weight

  • Height

  • Underlying medical conditions and use of various medications


That’s why it’s always safer to participate in research with Andarine after careful consideration and advice from a healthcare practitioner.

Where To Buy Andarine


Andarine is available online, but make sure you buy from a trusted source. Read up online to ensure you are clear on the product’s shipping procedures, third-party testing, money-back guarantee, etc.


Some websites provide free shipping to certain areas or with purchases above a certain size, and discounts when you subscribe using your email address.

Andarine: Legal Status


Andarine S-4 is legal to buy and sell. However, the FDA has not approved Andarine yet for consumer use. Many websites sell Andarine S-4 online, but not all of them are legal.


Make sure to buy Andarine from a website that sells the original product as a third party tested laboratory research chemical. 

Who Should Participate in Research with Andarine


It is advisable that you speak to your healthcare practitioner before participating in research with Andarine. However, it’s established that it is safer to stay away from this SARM if you belong to one of the following:


  • People who suffer from any severe ailment or with a serious medical history.

  • People with autoimmune disease

  • Those with mental illness

  • People with hormonal issues

  • People taking other medications or dietary supplements

  • Pregnant and lactating women

  • Cancer patients

  • People who have undergone or going to go through surgery

  • Those undergoing chemotherapy due to various reasons

  • People with eating disorders

  • Those who suffer from cardiovascular disease

  • People with blood disorders


Common Stacking Options For Andarine


Andarine S-4 may be used in combination with other SARMs in clinical research. Here are some common combinations frequently reported for Andarine S-4.


  • Andarine S-4 and Ostarine MK 2866: A combination of these may increase stamina, fat loss, endurance, bone strength, and lean muscle mass.

  • Andarine S-4 and Cardarine: This combination may help burn fat while retaining muscle volume and mitigating alterations in blood lipids.

  • Andarine S-4 and MK677: This combination may increase muscle mass via multiple pathways, the androgen-mediated pathway, and the growth hormone-mediated pathway.

  • Andarine S-4 and YK11: This combination may increase muscle mass through both the androgen-mediated pathway and the follistatin pathway.


It is important to note that the use of Andarine as well as the other above listed products are strictly experimental and the potential negative effects of these interactions are not yet fully understood so the supervision of a medical professional is critical for the protection of test subjects.

Andarine Vs Ostarine


Ostarine is often compared with Andarine due to similar effects, like lean muscle gain. However, this doesn’t mean that both are the same and that one can replace the other.


For instance, Ostarine is backed by many more clinical studies than Andarine and is about two to three times more potent per milligram administered. 


Both of these SARMs stimulate a noticeable amount of lean muscle mass. While they may be researched separately or together in clinical studies, it is important to be aware that their side effects may compound in these cases.



Andarine is the oldest SARM and may build lean muscle and burn fat and this is why this research chemical is so popular among researchers for advances in performance and recovery. For the time being it is only available as a research chemical for experimentation and participating in clinical research with Andarine should be done under the supervision of a healthcare professional.


Frequently Asked Questions

Does Andarine Build Muscle? 

Andarine binds to androgen receptors in the skeletal muscle and signals the bones and muscles of the body to grow.

Is Andarine Effective for Women? 

Andarine has demonstrated effectiveness in cutting body fat and maintaining muscle in both men and women but further research is necessary before it can be deemed safe. Pregnant women should not participate in research with Andarine.

How Long Does Andarine Remain In Your System? 

It is believed that Andarine may be detectable in urine for up to 40 days, more research is necessary for a medical consensus.





Gao W, Reiser PJ, Coss CC, Phelps MA, Kearbey JD, Miller DD, Dalton JT. Selective androgen receptor modulator treatment improves muscle strength and body composition and prevents bone loss in orchidectomized rats. Endocrinology. 2005 Nov;146(11):4887-97. doi: 10.1210/en.2005-0572. Epub 2005 Aug 11.


 Kearbey JD, Gao W, Narayanan R, Fisher SJ, Wu D, Miller DD, Dalton JT. Selective Androgen Receptor Modulator (SARM) treatment prevents bone loss and reduces body fat in ovariectomized rats. Pharm Res. 2007 Feb;24(2):328-35. doi: 10.1007/s11095-006-9152-9. Epub 2006 Oct 25. 

Bradley Davis. Nectac. Andarine S4: Uses, Side Effects, Safety & Research. Dec 13 2021 https://nectac.org/andarine-s4/



By purchasing from Sports Technology Labs you agree that you are purchasing Research Chemicals. These are chemical substances used by scientists for medical and scientific research purposes. One characteristic of a research chemical is that it is for laboratory research use only; the SARMs for sale on this website are not dietary supplements or muscle growth supplements for fitness enthusiasts and are not for consumer use. Products should be stored properly at room temperature and away from direct sunlight to maximize shelf life.
The statements made within this website have not been evaluated by the US Food and Drug Administration. These statements and the products of this company are not intended to diagnose, treat, cure or prevent any disease.
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