Effects of Ostarine on Muscle Tissue

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Did you know that the U.S. National Library of Medicine lists over 410,000 clinical trials in the United States and globally? Ostarine and SARMs research are taking up a more considerable portion of that number as more studies show promising results. 

SARMs products are primarily known as a replacement for testosterone or androgen steroid use, and Ostarine is one of the most widely tested. But does Ostarine indeed improve muscle tissue?

Ostarine’s current clinical studies affect muscle and bone growth, but other physiological effects are also indicated. 

In our complete guide on Ostarine, we will break down how it functions, what current studies show, and how you can be a part of future research, so keep reading for more information!

What Are SARMs?

SARMs is an acronym that stands for selective androgen receptor modulator. They are nonsteroidal chemical compounds with antagonist and agonist effects on androgen receptors. 

Some of the key differences noted between SARMs and androgenic steroids in clinical studies are:

  • Improved tissue selectivity
  • Lack of estrogen conversion
  • Improved efficacy with lower dosages

Researching localized and systemic effects depend on the SARMs type, dosage, and quality. Liquids and powders can yield more consistent results than capsules. Capsules are challenging to test and re-validate between batches. 

What Is Ostarine?

Ostarine is a popular type of SARM. There are many other SARMs compounds, such as:

  • Ibutamoren
  • Cardarine
  • Testolone
  • Ligandrol
  • Stenabolic
  • Andarine
  • And more

Many of these subtypes are better known for their number. Ostarine, or MK-2866, is a tissue-specific SARM yielding promising results on systemic muscle enhancements. Current studies also show improvements with:

  • Tissue healing
  • Bone healing
  • Fat loss

Other SARMs have shown encouraging results in trials for breast cancer, prostate cancer, and stress urinary incontinence.

The difficulty when testing Ostarine for research is finding high-quality and accurately labeled ingredients. Liquid forms are the most reliable, but some products do not detail other additives that could change study outcomes. 

Can Ostarine Improve Muscle Tissue?

Ostarine benefits muscle tissue growth by targeting tissue-specific androgen functions. The receptors help improve protein synthesis and muscle and bone growth without various androgenic side effects. 

In a 12-week Phase II clinical trial, Ostarine increased total lean body mass and showed promising effects to combat:

  • Muscle wasting
  • Sarcopenia
  • Cancer cachexia

Yet, one of the most significant barriers is for researchers to determine the ideal Ostarine dosage. Too much Ostarine has shown risks for organ damage and liver toxicity. 

Although to a much milder degree than unregulated usage, hepatoxic events were found in study participants. In the same study, the researchers examined drug-induced liver injury with an otherwise healthy male who used Ostarine for up to eight weeks prior for muscle growth. 

He presented with jaundice and other visual signs of liver damage with an abnormal liver biopsy. The patient required several months to recover liver enzyme levels. It should be noted that Ostarine (or any SARM) is not cleared for human consumption.

The patient was using Ostarine without medical guidance or under clinical trials and the purity of the product are unknown.

Can Ostarine Help With Tissue Repair?

In recent rat studies, Ostarine and Ligandrol were used treatments for post-menopausal symptoms. The goal of the study was to assess muscle mass and function. The Ostarine group showed improvements with:

  • Higher capillary density
  • Muscle vascularization
  • Muscle metabolism

Ligandrol showed minor changes in muscle size. Yet, the same was not seen in the Ostarine group. 

The changes in muscle vascularization indicate better tissue healing and contractility. Ostarine had a more profound effect on capillary density than Ligandrol, but it lagged behind Ligandrol for enzyme activity. 

Muscle enzymes also play a critical role in injury recovery. Ligandrol edged Ostarine for higher muscle enzyme activity effects. 

However, one of the Ostarine side effects was increased uterine weight. Mainly, this side effect was noted with higher dosages, making it critical for dose-dependent Ostarine research for muscle and tissue recovery. 

Ostarine vs. Testosterone

Testosterone therapy can have many adverse cardiovascular effects and affects reproductive organs. So far, Ostarine and other SARMs act as full antagonists or partial agonists on reproductive organs

Ostarine and other SARMs show less severity on common side effects that they share with testosterone therapy, such as: 

  • HDL levels
  • Liver function
  • Hypothalamic-pituitary-gonadal axis

One of testosterone’s largest limitations is its side effects in female use. Many androgen-specific drugs induce virilization. Ostarine may offer fewer issues and side effects with female use, broadening the target population of SARMs compared to steroid use. 

There is no research indicating how muscle strength improves mobility or function with SARMs trials. Additionally, there are no specific recommendations on an exercise regime or protein intake. 

The results compared to testosterone therapy are optimistic and can open the door for exciting and innovative research that can be used for more than isolated population groups. 

Ostarine Study Limitations

Ostarine is one of the most studied SARMs. It has progressed to phase 2a clinical studies and has even shown changes in insulin sensitivity. Unpublished studies also detail that Ostarine contributes to better survival rates for small cell lung cancer patients. 

Strength and muscle mass gains are considered modest compared to androgen steroid use. Purity and dosage could change the outcomes of this comparison, but safety and more extensive research is needed. 

Additionally, studies should target how muscle mass improvements relate to long-term changes in function. 

Future of Ostarine Research

Ostarine results from ongoing research trials are encouraging for what the future holds with SARMs. Its tissue-specific effects make it a unique chemical compound for treating multiple diseases and illnesses. 

Cancer and other debilitating diseases can cause muscle wasting or sarcopenia. Spearheading Ostarine research through high-quality products can help your team discover new and innovative ways Ostarine can be used

To start discovering Ostarine benefits, check out our entire SARMs product list!

References

Buy SARMs. Sports Technology Labs. 2022 Mar 31 [accessed 2022 Apr 20]. https://sportstechnologylabs.com/buy-sarms/

C. Kirksey, Your Ultimate 2021 SARMs Research Review. Sports Technology Labs (2022) (available at https://sportstechnologylabs.com/sarms-research/).

H. Bedi, C. Hammond, D. Sanders, M.-H. Yang, E. Yoshida, Drug-Induced Liver Injury From Enobosarm (Ostarine), a Selective Androgen Receptor Modulator. ACG Case Reports Journal (2021) (available at https://journals.lww.com/acgcr/fulltext/2021/01000/drug_induced_liver_injury_from_enobosarm.1.aspx).

Peixoto Da Fonseca GW, Von Haehling S, Ebner N, Dworatzek E. Selective androgen receptor modulators (SARMs) as pharmacological treatment for muscle wasting in ongoing clinical trials. Taylor & Francis. 2020 Jun 1 [accessed 2022 Apr 20]. https://www.tandfonline.com/doi/full/10.1080/13543784.2020.1777275

P. J. Roch et al., Ostarine and Ligandrol Improve Muscle Tissue in an Ovariectomized Rat Model. Frontiers (2020) (available at https://www.frontiersin.org/articles/10.3389/fendo.2020.556581/full).

S. Bhasin, SELECTIVE ANDROGEN RECEPTOR MODULATORS AS FUNCTION PROMOTING THERAPIES. The Journal of Frailty & Aging (2015) (available at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6039107/).

Sports Technology Labs, What to Know Before You Buy SARMs. Sports Technology Labs (2021) (available at https://sportstechnologylabs.com/what-to-know-before-you-buy-sarms/).

Trends, charts, and maps. ClinicalTrials.gov. [accessed 2022 Apr 20]. https://clinicaltrials.gov/ct2/resources/trends

Effects of Ostarine on Muscle Tissue

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