What is RAD-140 (Testolone)?

someone looking into the effects of RAD-140

RAD-140 is a SARM developed by Radius Health, Inc. for treatment of conditions like muscle wasting and breast cancer [1]. It exerts anabolic activity in muscle and connective tissue with little effect on the prostate and seminal vesicles. In addition, it may selectively compete and antagonize testosterone in these tissues. Scientists administered testosterone proprionate at 1mg/kg/day to castrated rats and co-administered RAD-140 at various doses to determine that 0.3-1mg/kg of RAD-140 counteracted 1mg/kg testosterone proprionate in prostate tissue and discovered a protective effect to the prostate from this compound [2]. RAD-140 has also displayed dramatic increase in lean body mass and cardioprotective effects via lowering blood lipids LDL, HDL, and triglycerides in clinical research [2].

rad140(testolone)

Buy RAD-140 (Testolone)

What Are the observed Effects of RAD-140?

What has grabbed the attention of the medical community with regards to RAD-140 is its neuroprotective effects. Higher levels of testosterone have been associated with slower buildup of β-amyloid plaques in the brain [3]. In vitro RAD-140 is shown to be as effective as testosterone in reducing cell death induced by apoptotic insults and required only three times as much concentration as testosterone to protect against β-amyloid proteins[3]. When tested in live rats, RAD-140 protected the brain against neuron loss from kianate exposure in a dose-dependent manner [3]. RAD-140 is prepared for a phase 1 clinical trial as a potential treatment for severe weight loss due to cancer cachexia [2]

What Are the Experimental Benefits of RAD-140?

1. Rapidly increased lean body mass

2. Potential neuroprotective effects and potentially decreased risk of β-amyloid-related dementia

3. Lower blood LDL, HDL, and triglycerides

4. Protection of the prostate from androgens like testosterone and DHT

 

AT THIS TIME, RAD140/TESTOLONE IS ONLY APPROVED FOR LABORATORY RESEARCH AND IS NOT SOLD FOR HUMAN CONSUMPTION.

 

References:

1. Anusha Jayaraman, Amy Christensen, V. Alexandra Moser, Rebekah S. Vest, Chris P. Miller, Gary Hattersley, Christian J. Pike, Selective Androgen Receptor Modulator RAD140 Is Neuroprotective in Cultured Neurons and Kainate-Lesioned Male Rats, Endocrinology, Volume 155, Issue 4, 1 April 2014, Pages 1398–1406, https://doi.org/10.1210/en.2013-1725
2. Miller, Chris P. et al. “Design, Synthesis, and Preclinical Characterization of the Selective Androgen Receptor Modulator (SARM) RAD140.” ACS Medicinal Chemistry Letters 2.2 (2011): 124–129. PMC.
3. Gouras GK, Xu H, Greenfield JP, Hai B, Wang R, Greengard P. Testosterone reduces neuronal secretion of Alzheimer’s beta-amyloid peptides. Proc Natl Acad Sci U S A. 2000 Feb 1;97(3):1202-5.



What is RAD-140 (Testolone)?

Leave a Reply

Your email address will not be published. Required fields are marked *