RAD-140 is a SARM developed by Radius Health, Inc. for treatment of conditions like muscle wasting and breast cancer . It exerts anabolic activity in muscle and connective tissue with little effect on the prostate and seminal vesicles. In addition, it may selectively compete and antagonize testosterone in these tissues. Scientists administered testosterone proprionate at 1mg/kg/day to castrated rats and co-administered RAD-140 at various doses to determine that 0.3-1mg/kg of RAD-140 counteracted 1mg/kg testosterone proprionate in prostate tissue . RAD-140 has also been shown to induce dramatic increase in lean body mass and cardioprotective effects via lowering blood lipids LDL, HDL, and triglycerides .
RAD-140 and Health Effects
What has grabbed the attention of the medical community with regards to RAD-140 is its neuroprotective effects. Higher levels of testosterone have been associated with slower buildup of β-amyloid plaques in the brain . In vitro RAD-140 is shown to be as effective as testosterone in reducing cell death induced by apoptotic insults and required only three times as much concentration as testosterone to protect against β-amyloid proteins. When tested in live rats, RAD-140 protected the brain against neuron loss from kianate exposure in a dose-dependent manner . RAD-140 is prepared for a phase 1 clinical trial as a potential treatment for severe weight loss due to cancer cachexia 
RAD-140 Investigational Benefits Summary:
1. Rapidly increases lean body mass
2. Exhibits neuroprotective effects and potentially decreases the risk of β-amyloid-related Alzheimer’s disease
3. Lowers blood LDL, HDL, and triglycerides
4. Protects the prostate from androgens
1. Anusha Jayaraman, Amy Christensen, V. Alexandra Moser, Rebekah S. Vest, Chris P. Miller, Gary Hattersley, Christian J. Pike, Selective Androgen Receptor Modulator RAD140 Is Neuroprotective in Cultured Neurons and Kainate-Lesioned Male Rats, Endocrinology, Volume 155, Issue 4, 1 April 2014, Pages 1398–1406, https://doi.org/10.1210/en.2013-1725
2. Miller, Chris P. et al. “Design, Synthesis, and Preclinical Characterization of the Selective Androgen Receptor Modulator (SARM) RAD140.” ACS Medicinal Chemistry Letters 2.2 (2011): 124–129. PMC.
3. Gouras GK, Xu H, Greenfield JP, Hai B, Wang R, Greengard P. Testosterone reduces neuronal secretion of Alzheimer’s beta-amyloid peptides. Proc Natl Acad Sci U S A. 2000 Feb 1;97(3):1202-5.