Long-Lasting Stability – Suspended in PEG-400 to ensure reliable solubility and shelf-life for research applications.
25mg/mL Concentration – A precisely measured liquid solution providing consistent results across studies.
Independently Verified – Third-party analysis confirms purity, concentration accuracy, and identity of every batch.
For Laboratory Research Only – Supplied strictly for scientific investigation, not for human consumption.
High-Quality Liquid MK-677 for Sale
MK-677 (Ibutamoren) — also referred to as Oratrope or Nutrobal in some research contexts — is a non-peptide spiropiperidine compound (molecular weight 528.662 g/mol) that functions as a ghrelin receptor (GHSR-1a) agonist and growth hormone secretagogue. It is a potent, long-acting, orally-active, selective agonist of the ghrelin receptor.
Unlike ghrelin, MK-677 is not a peptide, which allows it to be orally active and capable of crossing the blood–brain barrier. It acts on ghrelin receptors in the hypothalamus and pituitary gland to stimulate the growth hormone–IGF-1 axis, increasing circulating levels of both hormones.
Although MK-677 is sometimes grouped with selective androgen receptor modulators (SARMs) in non-scientific contexts, this classification is inaccurate, as it does not interact with the androgen receptor. Instead, MK-677 enhances endogenous hormonal secretion through neuroendocrine pathways without the direct suppressive effects typically associated with exogenous GH administration.
MK-677 vs. Other Growth Hormone Secretagogues
MK-677 is a potent ghrelin receptor agonist, not a hormone, that stimulates the body’s natural release of growth hormone (GH) and insulin-like growth factor 1 (IGF-1). While it is often listed alongside selective androgen receptor modulators (SARMs) in research chemical catalogs, this is a marketing grouping rather than a pharmacological classification, as MK-677 does not act on androgen receptors (Source).
Research shows that MK-677 has advantages over injectable growth hormone–releasing peptides (such as GHRP-6 and GHRP-2). A single oral dose of MK-677 produces a sustained elevation of IGF-1 for approximately 24 hours without disrupting the body’s natural pulsatile GH secretion. Its oral bioavailability makes it more convenient to administer in research compared to injectable peptides (Source).
Proper dosing is critical in research settings to maintain consistent hormonal elevations and reduce the risk of side effects. Clinical studies have demonstrated dose-dependent effects on GH and IGF-1, with excessive dosing potentially increasing the incidence of fluid retention, joint discomfort, and insulin resistance (Source).
Since it does not exert its effect via an androgen receptor, it is believed that MK-677 may improve body composition without negatively impacting endogenous androgen secretion, like testosterone and other anabolic compounds. Some data also suggests that MK-677 may have synergistic effects when combined with growth hormone-releasing peptides like Tesamorelin or Ipamorelin.
MK-677 FAQs
Studies have demonstrated the ability of MK-677 (aka Nutrobal) to raise endogenous levels of HGH and IGF-1. Clinical studies often compare post-treatment IGF-I levels to baseline values to assess the efficacy of MK-677 in stimulating the GH/IGF-I axis.
Available clinical evidence indicates that MK-677 is not associated with suppression of the body’s natural pulsatile growth hormone release, even with long-term daily administration. In both short-term and two-year clinical studies, MK-677 maintained endogenous GH pulsatility while elevating overall GH and IGF-1 levels. However, data beyond two years are limited, and further research is needed to fully understand its long-term regulatory effects (source), (source).
A two-year human study on MK-677 found that subjects experienced a significant decrease in the risk of developing gynecomastia compared to injectable growth hormone. In this study, the incidence of gynecomastia in the MK-677 group was also compared to a placebo group to assess the safety profile of the compound.
MK-677 does not act on the feedback loop for testosterone in the body and is not expected to suppress natural testosterone levels.
Data suggests that growth hormone secretagogues, like MK-677, may harm glucose tolerance and increase blood sugar levels with continuous testing.
The FDA has not approved MK‑677 (also known as Ibutamoren) for human consumption and remains classified as an investigational drug intended solely for scientific research.
MK‑677 remains under investigation; despite decades of research into its effects on growth hormone (GH), IGF‑1, body composition, and bone health, there is insufficient data on its long-term safety in healthy individuals. Long-term use of MK-677 is still being evaluated in clinical trial settings. Some side effects, such as fatigue, have been reported during prolonged oral treatment with MK-677 (Source).
Why choose Sports Technology Labs as the best place to buy MK-677?
The main reasons customers choose Sports Technology Labs for MK-677 include our commitment to product quality, safety, and reliable service. Independent research has shown that quality control in the broader SARM and research compound industry is highly inconsistent.
In a 2017 JAMA study analyzing 44 products sold online as SARMs, only 52% contained the advertised compound, 59% differed in quantity from what was on the label, 39% contained unapproved drugs, 25% included unlabeled substances, and 9% contained no active ingredient at all.
These findings underscore the critical importance of sourcing research compounds from reputable companies that provide third-party analytical testing to verify purity and identity.
Many companies have Ibutamoren for sale, but Sports Technology Labs is the best place to buy MK-677 online because of our consistent, verifiable, high-quality products, safe bottling and packaging, fast shipping, and excellent customer service. We also have MK-677 Nutrobal available in pure powder form.
When you buy SARMs from Sports Technology Labs, you are choosing the highest quality ingredients. Minimum 98% pure compounds tested and certified by accredited American third-party labs, suspended in USP-grade (the highest grade) PEG-400, bottled in America. Our products come in glass bottles with fixed glass droppers to prevent the leaching of unwanted plasticizers like Bisphenol A (BPA), and to avoid contamination when using external measuring tools.
We run a transparent business, with no discreet payment methods necessary and no misrepresentation of our products, only the highest quality research chemicals available online, secured by our 60-day money-back guarantee.
We provide free shipping for orders exceeding $149, and for those who require expedited delivery, we also offer express shipping. Customers who subscribe to our email list enjoy a 10% discount and an extra 10% off when paying with cryptocurrency.
Not every company provides the highest quality MK-677. At Sports Technology Labs, you can buy the best Ibutamoren with confidence. We ship most orders the same day or the next day, offer free shipping for orders over $149, and guarantee quality and fresh products every time.
Do not compromise your research with low-quality or unverified products—shop with Sports Technology Labs. You are welcome to contact us with any questions you have about our MK-677 for sale.
Additional information
Weight
3.0 oz
Ibutamoren/MK-677
All Sports Technology Labs SARMs are third-party tested by MZ Biolabs, an independent laboratory based in Arizona. Each batch is bottled and tested in the USA to ensure accuracy and purity. Our Certificates of Analysis confirm that products meet the listed specifications:
MK-677 (Ibutamoren) is a nonpeptide growth hormone secretagogue that stimulates the body’s endogenous production of growth hormone (GH) and insulin-like growth factor-1 (IGF-1). Unlike traditional peptide secretagogues, MK-677 is orally active, making it useful in research on GH regulation.
Clinical studies have linked MK-677 administration to increased GH and IGF-1 levels, with observed effects on lean mass, sleep quality, and body composition in specific populations. MK-677 remains an experimental compound intended strictly for laboratory research use only, not for human consumption.
MK-677 Mechanism of Action
MK-677 is a ghrelin receptor (GHSR-1a) agonist. By mimicking ghrelin, it stimulates the pituitary gland to release GH, which subsequently elevates circulating IGF-1 through hepatic stimulation. This hormonal cascade influences metabolism, muscle and bone physiology, and sleep regulation. Clinical studies have demonstrated that daily oral administration of MK-677 leads to sustained increases in GH and IGF-1 levels in elderly and GH-deficient subjects.
When administered orally, MK-677 Ibutamoren mimics the action of the hunger hormone ghrelin and, by doing so, increases growth hormones (GHs) in the body. It is potent in boosting levels of insulin-like growth factor 1 (IGF-1).
Unlike growth hormone and most GH-increasing peptides, Ibutamoren is orally bioavailable, so it does not require injection for proper absorption. Sports Technology Labs is the best place to buy MK-677 online due to our verified high purity, fast shipping, customer support, and secure payment processing.
MK-677 Benefits in Clinical Research
MK‑677 (ibutamoren) is an investigational growth hormone secretagogue that has shown multiple effects in vivo, primarily by significantly increasing GH and IGF‑1 secretion levels observed in younger adults. (Source)
Increase in Muscle Mass and Lean Body Mass: A 12‑month study in older adults found that 25 mg/day MK‑677 significantly increased fat‑free mass (~1.1 kg vs. −0.5 kg with placebo) while enhancing GH and IGF‑1 secretion. (Source)
Reduced Body Fat: Research in older adults observed improvements in body composition, including favorable fat distribution and a relative reduction in visceral fat alongside higher metabolic turnover. (Source)
Increase in Bone Density: MK‑677 treatment was shown to elevate bone turnover markers and bone mineral density in older and osteoporotic subjects, potentially counteracting age‑related bone loss. (Source)
Accelerated Muscle Growth and Faster Recovery: The compound supports anabolic processes through enhanced GH‑IGF‑1 axis activation, promoting muscle protein synthesis and recovery in populations with muscle wasting or post-injury contexts (e.g., hip fracture recovery trials showed improved stair climbing and gait speed). (Source)
Improved Immune Function: Though less extensively studied, GH elevation is known to support immune health, and MK‑677’s stimulatory effects on GH/IGF‑1 are proposed to enhance immune response in elderly and GH‑deficient individuals (Source)
Improved REM Sleep: A small trial (14 subjects) reported that 25 mg of MK‑677 daily increased REM sleep by ~20–50% and slow-wave sleep (deep sleep) by ~50% in younger and older participants. (Source)
Increased Appetite: MK‑677 is known to induce orexigenic effects—increasing hunger and food intake—particularly in older adults, which can support nutritional intake and anabolic gains. (Source)
Reversal or Treatment of Growth Hormone Deficiency: In GH‑deficient children and adults, Ibutamoren has been shown to increase GH and IGF‑1 levels, sometimes outperforming standard secretagogues in pediatric trials (Source)
These findings reflect promising therapeutic avenues in clinical and preclinical research. However, it is important to note that most benefits have been observed in older adults, GH‑deficient individuals, or animal models—not in healthy populations—and long‑term safety and efficacy remain under ongoing investigation.
Studies Involving MK-677
Medical studies conducted in the last decade have shown significant potential for MK-677 to encourage REM sleep, increase GH levels, and build lean muscle mass. Several studies and clinical trials have been conducted that suggest MK-677 holds enormous promise as a drug that could enhance health and potentially aid in the battle against frailty in the elderly by mitigating symptoms of the natural decline of growth factors that come with aging, also known as somatopause. Studies have been conducted on both young males (aged 19-49) and individuals aged 60-81.
Growth Hormone Release
Clinical studies have shown that MK-677 not only elevates growth hormone (GH) and insulin-like growth factor 1 (IGF-1) but also increases cortisol levels, likely through stimulation of the hypothalamic–pituitary–adrenal (HPA) axis via ghrelin receptor activation. This rise in cortisol is typically within physiological ranges but is a relevant factor when assessing the compound’s overall hormonal effects.
In addition, MK-677’s role as a ghrelin mimetic leads to increased appetite and food intake, a well-documented outcome in both clinical research and subjective reports. This effect is mediated by its action on ghrelin receptors in the hypothalamus, which regulate hunger and energy balance.
One study found that MK-677 administration increased IGF-I and IGF-binding protein-3 (IGFBP-3) levels, and potentially could be used to counter somatotropic deficiency and build muscle.
Muscle Growth and Body Composition
Research indicates that MK-677 increases lean body mass and bone mineral density, particularly in elderly individuals, through sustained elevations of GH and IGF-1. While these changes suggest potential benefits for muscle physiology and bone health, improvements in muscle strength or physical performance have been variable and population-specific. MK-677 remains of interest as a research tool for exploring muscle protein synthesis and anabolic pathways.
Another study found that MK-677 increased bone turnover, bone mineral density, muscle mass, and osteoblast activity in older adults and improved body composition.
A randomized controlled trial in healthy older adults found that daily 25 mg administration of MK-677 improved body composition, bone mineral density, and cholesterol levels, and stimulated appetite for several months.
A double-blind randomized controlled trial in healthy volunteers aged 24-39 on a calorie-restricted diet found that MK-677 significantly improved nitrogen retention even in an environment of negative nitrogen balance. This means that subjects maintained muscle mass even with a protein consumption considered less than sufficient. This may be of significant interest in the treatment of patients on parenteral nutrition or restricted to IV feeding.
Sleep Quality
A study on MK-677 and sleep quality revealed a significant decrease in REM latency and a 50% increase in REM sleep in older adults, as well as a 50% increase in stage 4 sleep and a 20% increase in REM sleep in young adults with the administration of MK-677. Stage 4 is the sleep stage in which the most tissue repair occurs, so this may be of significant interest in studies aimed at improving recovery and neurological function.
A placebo-controlled study involving both young and older adults found improvements in sleep quality when compared to the placebo after three separate seven-day administration trials.
Chronic Disease
Animal data suggest that MK-677 may be effective in reducing neuroinflammation, neurodegeneration, synapse loss, and slowing the early stages of beta amyloid buildup in the brain, a significant contributing factor for dementia and Alzheimer’s disease. The implications are that MK-677 may function as a preventative agent, not a curative agent, even in cases of genetic predisposition. More human data is necessary to confirm this.
Reversal of Diet-Induced Catabolism
In controlled studies, MK-677 has been shown to reverse diet-induced nitrogen loss in healthy volunteers under caloric restriction, indicating anticatabolic properties. These effects are thought to arise from increased GH/IGF-1 signaling and improved protein balance. Some studies, however, have reported mild increases in fasting glucose and insulin with prolonged use, suggesting the need for careful metabolic monitoring in research settings.
Effects on Appetite and Metabolism
Activation of the ghrelin receptor by MK-677 typically leads to increased appetite and food intake, which can support research on weight gain and nutrient regulation. However, increased appetite may also result in unintended fat gain if caloric intake exceeds energy expenditure. Reported side effects in clinical studies include water retention, transient joint discomfort, and mild insulin resistance, particularly with long-term use.
Potential Side Effects of Ibutamoren
It must be emphasized that MK-677 has not been approved by the Food and Drug Administration (FDA) for human consumption or efficacy. The severity of documented side effects like water retention, angiogenesis, and changes in blood pressure and blood sugar is still being determined. Potential drug interactions are also unknown at this time, so caution is critical with this compound.
Since it has a very long half-life, there is some concern that sustained administration of MK-677 can overstimulate or desensitize the ghrelin receptor in the human brain. Perhaps the most immediately noticeable side effect of Ibutamoren at this time is a significant increase in appetite and hunger.
It is in the preclinical stages of investigation for GH deficiency and should be used for research purposes only. Further important research into MK-677 will be performed in the years to come.
Documented and potential side effects in annectodal and case studies include:
Increased appetite and weight gain: MK-677 stimulates hunger through ghrelin receptor activation, often resulting in significantly higher caloric intake.
Swelling (edema): Due to water retention, which can contribute to rapid weight gain.
Joint pain, numbness, and fatigue: these are commonly reported in clinical trials and user observations, often linked to fluid shifts and elevated IGF-1.
Elevated fasting blood glucose and insulin levels: long-term use may increase the risk of developing insulin resistance or type 2 diabetes, likely due to chronically elevated IGF-1 and GH levels.
Increased cortisol levels: May affect metabolism and fluid balance.
Cardiovascular concerns: In one clinical trial involving elderly patients, the study was halted early due to increased rates of congestive heart failure in participants receiving MK-677 compared to placebo (Nass, 2018). Some research suggests a potential cardiovascular strain associated with chronic GH/IGF-1 elevation; however, more studies are needed.
Storage: Store in a cool, dry place away from direct sunlight to maximize shelf life.
30 mL of liquid MK-677 per bottle with 25 milligrams per milliliter.
Includes a graduated 1 mL glass pipette for convenient measurement.
Glass bottle with UV resistance to minimize degradation.
Tamper-proof seal to ensure safety in transit.
Less than 5% variance in concentration, guaranteeing consistency.
Formulated and packaged to prevent evaporation in storage.
SKU: 5
This preparation is a research chemical for laboratory research use only and is not approved by the FDA for human use. MK–677/Ibutamoren IS NOT A DIETARY OR SPORTS SUPPLEMENT.
Abuse Warning
MK-677 is an investigational compound still awaiting FDA approval and is not a dietary supplement. At Sports Technology Labs, we are chemical suppliers, not medical doctors, and our expertise is sourcing and quality control. Sports Technology Labs does not encourage or condone consumer use of SARMs products; they are for research purposes only.
SARMs should only be used under the supervision and direction of a medical doctor or designated research authority. We strongly discourage the use of SARMs for performance enhancement in sports and bodybuilding, and caution against relying on “bro science” and peer consensus when making decisions about human health.
Regulatory and Anti-Doping Status
MK-677 (Ibutamoren) is prohibited by the World Anti-Doping Agency (WADA) under the category of “Peptide Hormones, Growth Factors, Related Substances, and Mimetics” (S2). It is banned both in-competition and out-of-competition, and its use in all legitimate sports competitions governed by WADA or organizations adopting the WADA Code is illegal.
While MK-677 is not a controlled substance in some countries, including the United States, and can be legally purchased and possessed for research use, it is not approved for human consumption or medical use. Marketing it as a supplement or for ingestion is illegal.
Athletes subject to anti-doping rules should be aware that use of MK-677 can result in disqualification, suspension, or other sanctions if detected during testing (source)
Scientific References:
1. G Copinschi, A Van Onderbergen, M L’Hermite-Balériaux, C M Mendel, A Caufriez, R Leproult, J A Bolognese, M De Smet, M O Thorner, E Van Cauter, Effects of a 7-day treatment with a novel, orally active, GH secretagogue, MK-677, on 24-hour GH profiles, IGF 1, and adrenocortical function in normal young men, The Journal of Clinical Endocrinology & Metabolism, Volume 81, Issue 8, 1 August 1996, Pages 2776–2782
2. Murphy MG, Bach MA, Plotkin D, Bolognese J, Ng J, Krupa D, et al. Oral administration of the growth hormone secretagogue MK-677 increases markers of bone turnover in healthy and functionally impaired elderly adults. The MK-677 Study Group. J Bone Miner Res. 1999;14:1182–1188L
3. Patchett AA, Nargund RP, Tata JR, Chen MH, Barakat KJ, Johnston DB, Cheng K, Chan WW, Butler B, Hickey G, et al. Design and biological activities of L-163,191 (MK-0677): a potent, orally active GH secretagogue. Proc Natl Acad Sci U S A. 1995 Jul 18;92(15):7001-5. doi: 10.1073/pnas. 92.15.7001. PMID: 7624358; PMCID: PMC41459.
4. Meyer RM, Burgos-Robles A, Liu E, Correia SS, Goosens KA. A ghrelin-growth hormone axis drives stress-induced vulnerability to enhanced fear. Mol Psychiatry. 2014 Dec;19(12):1284-94. doi: 10.1038/mp. 2013.135. Epub 2013 Oct 15. PMID: 24126924; PMCID: PMC3988273.
6. Smith RG, Sun Y, Jiang H, Albarran-Zeckler R, Timchenko N. Ghrelin receptor (GHS-R1A) agonists show potential as interventive agents during aging. Ann N Y Acad Sci. 2007 Nov;1119:147-64. doi: 10.1196/annals. 1404.023. PMID: 18056963.
7. Nass R, Pezzoli SS, Oliveri MC, Patrie JT, Harrell FE Jr, Clasey JL, Heymsfield SB, Bach MA, Vance ML, Thorner MO. Effects of an oral ghrelin mimetic on body composition and clinical outcomes in healthy older adults: a randomized trial. Ann Intern Med. 2008 Nov 4;149(9):601-11. doi: 10.7326/0003-4819-149-9-200811040-00003. PMID: 18981485; PMCID: PMC2757071.
8. Murphy MG, Plunkett LM, Gertz BJ, He W, Wittreich J, Polvino WM, Clemmons DR. MK-677, an orally active growth hormone secretagogue, reverses diet-induced catabolism. J Clin Endocrinol Metab. 1998 Feb;83(2):320-5. doi: 10.1210/jcem. 83.2.4551. PMID: 9467534.
9. Jeong YO, Shin SJ, Park JY, Ku BK, Song JS, Kim JJ, Jeon SG, Lee SM, Moon M. MK-0677, a Ghrelin Agonist, Alleviates Amyloid Beta-Related Pathology in 5XFAD Mice, an Animal Model of Alzheimer’s Disease. Int J Mol Sci. 2018 Jun 18;19(6):1800. doi: 10.3390/ijms19061800. PMID: 29912176; PMCID: PMC6032329.
10. Copinschi G, Leproult R, Van Onderbergen A, Caufriez A, Cole KY, Schilling LM, Mendel CM, De Lepeleire I, Bolognese JA, Van Cauter E. Prolonged oral treatment with MK-677, a novel growth hormone secretagogue, improves sleep quality in man. Neuroendocrinology. 1997 Oct;66(4):278-86. doi: 10.1159/000127249. PMID: 9349662.
11. Van Wagoner RM, Eichner A, Bhasin S, Deuster PA, Eichner D. Chemical Composition and Labeling of Substances Marketed as Selective Androgen Receptor Modulators and Sold via the Internet. JAMA. 2017 Nov 28;318(20):2004-2010.
12. WADA Prohibited List (2025): Section S2: Peptide Hormones, Growth Factors, Related Substances, and Mimetics. WADA.org
13. U.S. Food and Drug Administration. “FDA Warns Against the Use of Selective Androgen Receptor Modulators (SARMs).” (While MK-677 is not a SARM, it is often sold alongside them; the same legal principles apply to research chemicals marketed for human use.)
