Liquid Ibutamoren (MK 677) – 25MG/ML

High Quality Liquid MK 677 for Sale

MK 677, also known as Ibutamoren, Oratrope, or Nutrobal (molecular weight 528.662), is a ghrelin agonist that acts on the pituitary gland as a human growth hormone secretagogue and is sometimes classified along with selective androgen receptor modulators (SARMs). It differs from Ghrelin itself in that it is not a peptide but rather a spiropiperidine. Since it can cross the blood-brain barrier, MK-677 functions as a neuropeptide in the central nervous system.

MK 677 vs other Growth Hormone Secretagogues

It is a very powerful hormone and it is not uncommon to find Ibutamoren and SARMs for sale in the same catalog. Data shows that MK-677 has an advantage over compounds like GHRP-6 and GHRP-2 in that it elevates IGF-1 levels for 24 hours after a single dose without inhibiting natural pulsatile growth hormone release. Since it does not exert its effect via androgen receptor, it is believed that MK677 may improve body composition without negatively impacting endogenous androgen secretion like Testosterone and other anabolic compounds. Some data also suggests that MK677 may have synergistic effects when combined with growth hormone releasing peptides like Tesamorelin or Ipamorelin.

MK 677 mechanism of action

When administered orally, MK 677 Ibutamoren mimics the action of the hunger hormone ghrelin and, by doing so, increases growth hormones (GHs) in the body. It is powerfully effective in boosting levels of insulin-like growth factor 1 (IGF-1). Unlike growth hormone and most GH increasing peptides, Ibutamoren is orally bioavailable so it does not require injection for proper absorption. Sports Technology Labs is the best place to buy MK-677 for sale on the internet due to their verified high purity, fast shipping, customer support, and secure payment processing.

MK 677 Benefits in Clinical Research

MK 677 has displayed multiple effects in vivo, including:

• Increase in GH levels
• Increase in muscle mass and lean body mass
• Reduced body fat
• Increase in bone density
• Faster muscle growth
• Improved immune function
• Improved REM sleep
• Increased appetite
• Reversal of growth hormone deficiency
• Alleviation of pathology related to beta amyloid

Studies involving MK 677

Medical studies conducted in the last decade have shown significant potential for MK 677 to encourage REM sleep, increase GH levels, and build lean muscle mass. Several studies and clinical trials have been conducted that suggest MK-677 holds enormous promise as a drug that could enhance health and potentially aid in the battle against frailty in the elderly by mitigating symptoms of the natural decline of growth factors that comes with aging, also known as somatopause. Studies have been conducted on both young males (age 19-49) as well as men and women between the ages of 60 and 81.

MK 677 and Growth Hormone Release

• One study found that MK-677 administration increased IGF-I and IGF-binding protein-3 (IGFBP-3) levels, and potentially could be used to counter somatotropic deficiency and build muscle.

MK 677 and Body Composition

• Another study found that MK-677 increased bone turnover, bone mineral density, muscle mass, and osteoblast activity in older adults and improved body composition .
• A randomized controlled trial in healthy older adults found that daily administration of 25mg per day MK677 improved body composition, bone mineral density, and cholesterol levels while improving appetite for several months.
• A double-blind randomized controlled trial in healthy volunteers ages 24 – 39 on a calorie restricted diet found that MK677 significantly improved nitrogen retention even in an environment of negative nitrogen balance. This means that subjects maintained muscle mass even with was considered less than sufficient protein consumption. This may be of significant interest in the treatment of patients on parenteral nutrition or restricted to IV feeding .

MK 677 and Sleep Quality

• A study on MK 677 and sleep quality revealed a significant decrease in REM latency and a 50% increase REM sleep in older adults, as well as a 50% increase in stage 4 sleep and a 20% increase in REM sleep in young adults with the administration of MK677. Stage 4 is the sleep stage in which the most tissue repair occurs so this may be of significant interest in studies aimed at improving recovery and neurological function.
• A placebo-controlled study involving both young and older adults found improvements in sleep quality when compared to the placebo after three separate seven day administration trials.

MK 677 and Chronic Disease

• Animal data suggests that MK677 may be effective in reducing neuroinflammation, neurodegeneration, synapse loss, and slowing the early stages of beta amyloid build up in the brain, a significant contributory factors for dementia and Alzheimer’s Disease. The implications are that MK 677 may function as a preventative agent, not a curative agent, even in cases of genetic predisposition. More human data is necessary to confirm this.

Potential side effects of Ibutamoren

However, it must be emphasized that MK-677 has not been approved by the Food and Drug Administration (FDA) for human consumption and efficacy. The severity of documented side effects like water retention, angiogenesis, and changes in blood pressure and blood sugar are still being determined. Potential drug interactions are also unknown at this time so caution is critical with this compound.

Since it has a very long half life, there is a some concern that sustained administration of MK-677 can overstimulate or desensitize the ghrelin receptor in the human brain. Perhaps the most immediately noticeable side effect of Ibutamoren at this time is a significant increase in appetite and hunger.

It is in the preclinical stages of investigation for GH-deficiency and should be used for research purposes only. Further important research into MK-677 will be performed in the years to come.