Exploring A Randomized, Controlled Trial with MK-677 Ibutamoren Mesylate

MK-677 Overview

What if your next research opportunity were just around the corner?

More researchers are discovering the opportunities presented by ibutamoren mesylate (better known as Mk-677). It releases a growth hormone into the body that could, in time, revolutionize many different fields. However, research into MK-677 and its benefits has, so far, been relatively limited.

But what is ibutamoren mesylate? What is driving research related to this novel growth hormone secretagogue? What has past research revealed, and what research opportunities are still waiting to be found? Below, we have all of the information that you need.

Where Investigation Began

Investigations into the potential clinical applications of growth hormone have witnessed a surge in the past decade, primarily driven by the availability of human recombinant growth hormones (hGH). 

The efficacy and tolerability of growth hormone replacement were established in growth hormone deficiency; however, its utilization remained limited until the mid-1980s. This restriction stemmed from the scarcity of growth hormone, which was derived from the pituitary glands of deceased individuals.

The purity of extracted growth hormone became a concern due to its association with outbreaks of Jacob-Creutzfeldt disease, a fatal neurodegenerative disorder. Nonetheless, the advent of recombinant growth hormone manufacturing in the 1980s motivated researchers to explore the potential uses of growth hormone beyond treating growth hormone deficiency. 

Consequently, investigators were prompted to delve into the fundamental mechanisms governing the episodic nature of growth hormone release and the cellular functions of growth hormone to aid in growth hormone production.

What Is Ibutamoren Mesylate?

Our guide will tell you everything you need to know about ibutamoren mesylate, a growth hormone secretagogue. Before we go any further, though, we need to answer the obvious question: just what is MK-677, anyway?

The short answer is that MK-677 is a special compound created to mimic the effects of the body’s ghrelin receptor. And that receptor helps to release growth hormone (GH) into the body. This is why MK-677 is known as a growth hormone that assists in treating this growth hormone deficiency. The receptor is also responsible for regulating appetite, expending energy, and accumulating fat.

What would researchers do with liquid MK-677? Conduct further testing! Studies show that in addition to boosting the body’s growth hormone, it also increases the body’s insulin-like growth factor. Both play a significant role in the body’s muscles, as well as cellular regeneration and recovery.

A Closer Look At What Ibutamoren May Present in Research

Research suggests that ibutamoren mesylate MK-677 contributes significantly to muscle growth. This occurs because, as we noted before, the compound stimulates the body’s growth hormone and IGF-1.

Another component being studied is how the compound reduces the amount of muscle waste when a subject isn’t getting enough protein. This can also be helpful for subjects who need answers for a catabolic condition. MK-677 may also contribute to increased bone density and anti-aging efforts.

How do we know so much about MK-677? A variety of studies back up our data over the years, and we’re going to explore further what these studies discovered.

The Impact On Older Subjects

One particular study helped explore the benefits of MK-677 on older subjects, and the results were quite interesting!

The study focused on how MK-677 worked on “older healthy adults.” In addition to boosting growth hormone levels, the study found that the compound induced “increased rejuvenation over 12 months.”

The study also confirmed the limits of what MK-677 could do. Specifically, it confirmed that “Strength, function, and quality of life did not improve after administration of MK-677 in this study of a small, healthy cohort.” 

However, the researchers conceded that it may have had more benefits in these areas if they had been studying older subjects who were frailer than those in their test group. The sleep quality of these subjects was not tested during this time.

MK-677 and Muscle Mass

Some of the biggest proponents of MK-677 are that it helps to build and protect muscle. Older subjects are also interested in preserving mass, but does the research support these claims about MK-677?

In a study back in 2008, researchers looked at what MK-677 could do for aging subjects. They discovered that the compound restored 20% of the muscle loss that typically comes from aging. 

More research must be conducted to validate these findings regarding muscle size and how MKK677 can prevent muscle wasting from aging and chronic disorders. Growth hormone deficiency affects many, and through further research, new treatments for these diseases can be found.

The Limits and Potential of MK-677 Research

Previously, we noted that MK-677 offers many research opportunities to the right scientists and scholars. But if this compound has been well-researched over the years, what more is there to look into?

While the benefits and drawbacks of MK-677 have been studied before, a commonality among most studies of MK-677 is that very few research subjects participated in clinical trials.

The result is that while MK-677 seemingly has a lot of potential, there is a serious need for both additional study and more widespread study. And it’s easier than ever for researchers to take a closer look at this compound. 

Does it improve or worsen sleep quality? Does it alleviate muscle wasting? Does it affect brain regions differently than any other compound? All of these questions must continue to be explored. For information comparing MK-677 to other growth hormone secretagogues, see our review of MK-677 vs. Ipamorelin vs. GHRP-6.

The Importance of Finding the Right Vendor

However, this brings with it a potential issue: the need to find a reliable vendor that understands your research needs and offers the necessary supplies. Product quality and purity are of paramount importance for accurate test results in research. This is why it’s essential to only go after the best MK-677 for sale online. When it’s time to conduct your research, you need look no further than Sports Technology Labs.

Get the Ibutamoren You Need Today

Now you know more about ibutamoren mesylate and its potential for future research studies. But if you’d like to research this compound in greater detail, do you know whom you can turn to? Don’t be like the people who buy Ostarine on Etsy; do your research with a professional company that sends their products to accredited third-party laboratories for testing.

Here at Sports Technology Labs, we make it easy for researchers to begin studying the effects of liquid MK-677. Please contact us today to understand more about this compound. Not sure where to start your research? 

Explore our selection of SARMs for sale. Results may be noteworthy for future exploration and endeavors.

Scientific References:

1. Bowers, C. Y., Laferrére, B., Hurley, D. L., & Veldhuis, J. D. (2008). The role of growth hormone secretagogue and ghrelin in feeding and body composition. Energy Metabolism and Obesity: Research and Clinical Applications, 125-154.

2. García, J. M., & Polvino, W. J. (2009). Pharmacodynamic hormonal effects of anamorelin, a novel oral ghrelin mimetic and growth hormone secretagogue in healthy volunteers. Growth Hormone & IGF Research, 19(3), 267-273.

3. Nass, R., Pezzoli, S. S., Oliveri, M. C., Patrie, J. T., Harrell Jr, F. E., Clasey, J. L., … & Thorner, M. O. (2008). Effects of an oral ghrelin mimetic on body composition and clinical outcomes in healthy older adults: a randomized trial. Annals of internal medicine, 149(9), 601-611.

4. Murphy, M. G., Plunkett, L. M., Gertz, B. J., He, W., Wittreich, J., Polvino, W. M., & Clemmons, D. R. (1998). MK-677, an orally active growth hormone secretagogue, reverses diet-induced catabolism. The Journal of Clinical Endocrinology & Metabolism, 83(2), 320-325

5. Smith, R. G. (2000). Overview of Human Growth Hormone: Research and Clinical Practice. Human Growth Hormone: Research and Clinical Practice, 1-13