4 Recent SR9009 Case Studies, Their Findings, and Where to Buy SR9009

SR 9009 Introduction

Over recent years there has been a lot of discussion surrounding SARMs like SR 9009. These discussions have often been spurred by case studies and laboratory research looking at the effects of SR 9009.

SR 9009 studies are opening many doors to new discoveries. If you’re looking to conduct research, it’s important to do a literature review beforehand. 

Keep reading this guide for recent case studies that have looked at this selective androgen receptor modulator (SARM). 

One: Lung Cancer

For research purposes, a recent study tested SR 9009 and its effects on targeting small cell lung cancer (SCLC Cells). This study posited that the circadian rhythm coordinates cell proliferation and metabolism, which can impact how some diseases progress.

Because of this, researchers wanted to see if pharmacological modulation of the circadian rhythm could potentially be an effective way to help treat cancer.

The Basics

 For this study, chemosensitive cells and their corresponding chemoresistant cells consisted of the following :

• H69
• H446
• H69AR
• H446DDP

The cells were used to look at whether the REV ERBA SR 9009 aided in the treatment of small-cell lung cancer in vitro.

The Results and Conclusions

The great results of the study showed that the REV ERBA SR 9009 was lethal to chemoresistant and chemosensitive SCLC cells. There was an antitumor effect that REV-ERBα was involved in.

REV-ERBα targeted the core autophagy gene Atg5, and this gene was suppressed by REV ERB agonists SR 9009. In addition, the interaction of REV-ERBα with the Atg5 caused impairment to autophagy activity. This led to SR 9009 cytotoxicity in the small cell lung cancer cells.

The conclusions drawn by researchers because of the results of this study state that the REV ERB agonists SR 9009 has the potential to be a novel and promising treatment strategy for the first or second line of small cell lung cancer, but more research must be conducted to verify these results.

Two: Alzheimer’s Disease

The next case study discussed involves Alzheimer’s disease. The study shared how there are a lack of treatments that can reverse the pathology and cognitive deficits that occur in subjects with Alzheimer’s.

In mouse models, reduced cognitive function gets associated with a loss of function in the nuclear REV ERB receptors. Because the effect of enhancing REV-ERB function on cognitive function hasn’t been examined, this study did.

The Basics

The purpose of this particular study was to test a hypothesis that enhancing REV-ERB function could also enhance cognitive function in a model of Alzheimer’s.

The study used 72 treated mice and divided them into three groups. These consisted of:

• Four-month-old mice getting vehicle (Y-V) 
• 12-month-old mice getting vehicle (O-V) 
• 12-month-old mice getting SR9009

All mice treated underwent three behavioral tests to explore how they responded to the study. The behavioral tests consisted of novel object recognition, lever press operant conditioning, and T-maze foot shock avoidance.

The Results and Conclusions

During the novel object recognition time task, a reduced amount of time spent exploring a novel object was connected with reduced cognitive function. This is because the natural tendency of mice is to explore new aspects of the environment they’re in.

 The O-V mice showed a reduced cognitive function when comparing them to the Y-V mice. But, in almost every case, the SR9009 stenabolic testing showed a cognitive function that was improved significantly. Researchers stated that in many cases, the cognitive function in the SR9009 stenabolic group was not distinguishable from the younger mice.

For the T-maze foot shock avoidance task, the group of mice undergoing SR9009 stenabolic testing had significantly improved retention. However, the effect on acquisition was not as pronounced in this group.

The third task, lever press reward conditioning, also showed that mice receiving the SR 9009 testing had improved performance. Because of the results of the three tasks, researchers concluded that SR 9009 testing can improve cognitive function in a mouse model of Alzheimer’s disease. 

They also concluded that it’s possible that REV-ERB could possibly be a method utilized to treat Alzheimer’s and other cognitive disorders. In the future, control groups should be utilized to further validate results findings.

Three: Cell Proliferation and Metabolism

The final study we will look at for today involved the independent REV-ERB effects SR 9009 has on cell proliferation and metabolism. This study noted the fact that there have been many reported effects of SR 9009 when utilized in animal studies with cell systems and health or diseased animal models. 

But, researchers have failed to thoroughly assess the direct involvement of REV-ERBs in the effects of SR 9009. 

For this study, researchers used a conditional REV-ERBα/β double-deletion mouse model. They tested the specificity of SR 9009 and a related compound. 

The Results and Conclusions

In completing this study, researchers found that SR9009 can exert REV-ERB independent effects on metabolism, proliferation, and gene transcription. It can do this in two different cell types depleted of REV-ERBs. 

Because of this, researchers have concluded that the effects of SR 9009 can’t only get attributed to actions on REV-ERBs. The researchers believe that this information is important for anyone using SR 9009 for research on treatment methods for various diseases. 

How this product affects lipid and glucose metabolism should further be studied by researchers. A possible model can be to utilize diet-induced obese mice as test subjects. 

Four: Diet-Induced Obese Mice Leading the Way