Over recent years there has been a lot of discussion surrounding SARMs like SR9009. These discussions have often been spurred by case studies and research looking at the effects of SR9009 and what kind of diseases it can treat.
The potential uses discovered by SR9009 studies are opening many doors. If you’re looking to do your own research, it’s important to do a literature review beforehand.
Keep reading this guide for recent case studies that have looked at this SARM.
One: Lung Cancer
The first case study we’re going to explore looked at using SR9009 for small cell lung cancer. This study posited that the circadian clock coordinates cell proliferation and metabolism, which can impact how some diseases progress. Because of this, researchers wanted to see if pharmacological modulation of the circadian machinery could potentially be an effective way to help treat cancer.
For this study, chemosensitive cells and their corresponding chemoresistant cells were used. These consisted of the following:
The cells were used to look at whether the REV-ERB agonist SR9009 aided in the treatment of small-cell lung cancer in vitro.
The Results and Conclusions
The results of the study showed that the REV-ERB agonist SR9009 was lethal to chemoresistant and chemosensitive small cell lung cancers cells. There was an antitumor effect that REV-ERBα was involved in.
REV-ERBα targeted the core autophagy gene Atg5, and this gene was suppressed by REV-ERB agonist SR9009. In addition, the interaction of REV-ERBα with the Atg5 caused impairment to autophagy activity. This led to SR9009 cytotoxicity in the small cell lung cancer cells.
The conclusions drawn by researchers because of the results of this study state that the REV-ERB agonist SR9009 has the potential to be a novel and promising treatment strategy for the first or second line of small cell lung cancer.
Two: Alzheimer’s Disease
The next case study we’re going to look at involved Alzheimer’s disease. There is a lack of treatments that can reverse the pathology and cognitive deficits that occur in patients with Alzheimer’s.
In mouse models, reduced cognitive function gets associated with a loss of function in the nuclear receptor REV-ERB. Because the effect of enhancing REV-ERB function on cognitive function hasn’t been examined, this study did so.
The purpose of this particular study was to test a hypothesis that enhancing REV-ERB function could also enhance cognitive function in a model of Alzheimer’s.
The study used 72 mice and divided them into three groups. These consisted of:
- Four-month-old mice getting vehicle (Y-V)
- 12-month-old mice getting vehicle (O-V)
- 12-month-old mice getting SR9009
All mice underwent three behavioral tests to explore how they responded to the treatment they received. The behavioral tests consisted of novel object recognition, lever press operant conditioning, and T-maze foot shock avoidance.
The Results and Conclusions
During the novel object recognition time task, a reduced amount of time spent exploring a novel object was connected with reduced cognitive function. This is because the natural tendency of mice is to explore new aspects of the environment they’re in.
The O-V mice showed a reduced cognitive function when comparing them to the Y-V mice. But, in almost every case, the SR9009 treatment showed a cognitive function that was improved significantly. Researchers stated that in many cases, the cognitive function in the SR9009 group was not distinguishable from the younger mice.
For the T-maze foot shock avoidance task, the group of mice undergoing SR9009 treatment had significantly improved retention. However, the effect on acquisition was not as pronounced in this group.
The third task, lever press reward conditioning, also showed that mice receiving the SR9009 treatment had improved performance. Because of the results of the three tasks, researchers concluded that SR9009 treatment can improve cognitive function in a mouse model of Alzheimer’s disease and that it’s possible that REV-ERB could possibly be a method utilized to treat Alzheimer’s and other cognitive disorders.
Three: Cell Proliferation and Metabolism
The final study we will look at for today involved the independent REV-ERB effects SR9009 has on cell proliferation and metabolism. This study noted the fact that there have been many reported benefits of SR9009 when utilized in studies with cell systems and health or diseased animal modes.
But, researchers have failed to thoroughly assess the direct involvement of REV-ERBs in the effects of SR9009.
For this study, researchers used a conditional REV-ERBα/β double-deletion mouse model. They tested the specificity of SR9009 and a related compound.
The Results and Conclusions
In completing this study, researchers found that SR9009 can exert REV-ERB independent effects on metabolism, proliferation, and gene transcription. It can do this in two different cell types depleted of REV-ERBs.
Because of this, researchers have concluded that the effects of SR9009 can’t only get attributed to actions on REV-ERBs. The researchers believe that this information is important for anyone using SR9009 for research on treatment methods for various diseases.
Buy SR9009 for Your Research
There are still many scientific studies on SR9009 that need to be completed to understand how it could help in a variety of diseases. However, researchers are finding potentially promising uses of SR9009 for many diseases and for use in other forms.
Make sure you’re keeping up on the research, and when you’re ready to start your own research, know that we’re here for you. Sports Technology Labs has the high-quality SARMs you need to complete your research. Contact us today; we would love to discuss your SARMs needs with you.