Treating Male Infertility With Enclomiphene Citrate

Nearly 1 in 7 couples who are having unprotected sex for over a year are facing infertility issues. You might be surprised to learn that of those who are having fertility issues, half are from male-related issues. 

Many people assume that if a couple is facing infertility, it’s related to issues with the woman due to the complexity of the female reproductive system and involvement in the gestation process. However, the stats show that isn’t always the case. 

What are the issues related to male infertility and how can it be treated? Some suggest to treat male infertility with Enclomiphene Citrate, a drug that is used to stimulate testosterone levels in men. 

Read on to learn more about male infertility and how Enclomiphene Citrate is being used as a fertility drug for men.

What Is Male Infertility?

Male infertility is more common than most couples realize. It’s the male’s inability to provide sperm to attach to the female egg and create gestation. 

Male infertility can result from:

  • Low sperm production
  • Abnormal sperm function
  • Blockages that prevent the delivery of sperm

Symptoms of male infertility are pretty rare, except for the inability to conceive a child. However, some males suffer from underlying conditions that can create the side effect of male infertility. Some of these conditions include:

  • An inherited disorder
  • Dilated veins around the testicle
  • Hormonal imbalance
  • A condition that blocks the passage of sperm 

What signs and symptoms should you watch out for if you’re struggling to conceive? 

Some men will struggle with their sexual function. This might include trouble ejaculating or very small amounts of fluid during ejaculation. You might feel reduced sexual desire or difficulty maintaining an erection. 

You may have swelling, pain, or a lump in the testicle area. This would be something to see your doctor about right away. At the same time, your doctor can test your sperm count. 

Non-sex-related symptoms might also include difficulty with smell, recurring respiratory infections, and abnormal breast growth.  Some men may even show a decrease in facial or body hair. You should watch for other signs of hormonal abnormalities too.

Diagnosis of Male Infertility

The inability to conceive a child can be frustrating. If you’re concerned you may have an issue with male infertility, what should you do? First, remember it can take time to conceive a child. 

You should get a physical to make sure you’re in good health. You should also go a year of having unprotected sex before you have any real need to start investigating. 

Having said that, if you have any of the following warning signs, it might be time to see your doctor sooner. Symptoms might include:

  • Erection or ejaculation problems
  • Partner over 35 years of age
  • A lump or swelling in the testicle area
  • Pain in the testicle area
  • A history of testicle, prostate, or sexual problems
  • A groin, testicle, penis, or scrotum surgery

If you’re concerned about male infertility, again start with a regular physical. Then you and your partner should see a fertility specialist.  The specialist can look at both of you to consider potential causes. The doctor will start with a general examination and a sperm analysis. 

Treating Male Infertility

The first thing a fertility specialist will want is a good analysis of sperm count. Then they will begin to look at what’s causing the sperm count problem and infertility. 

There are a variety of tests that could be done to evaluate infertility:

  • Scrotal ultrasound
  • Transrectal ultrasound
  • Hormone testing
  • Post-ejaculation urinalysis
  • Genetic tests
  • Testicular biopsy

Treatment for infertility will vary depending on the issue causing infertility. Sometimes it means surgery to address a blockage. Often it means treating a hormonal condition.

What Are SERMs?

Enclomiphene Citrate is one new treatment for male infertility. It’s a SERM or Selective Estrogen Receptor Modulator. A SERM is a medication that is used to either stimulate or block female estrogen receptors. 

SERMs are used for a variety of health conditions. Some are used as part of treatment for breast cancer and osteoporosis. SERMs are often used for postmenopausal women. One SERM, clomiphene citrate or Clomid, is also used to stimulate ovulation for women facing infertility. 

In men, SERMs are used to combat male hypogonadism by stimulating testosterone production and fertility. Clomiphene citrate is the most common choice but Enclomiphene citrate is a new product available for this purpose. 

What Is Enclomiphene Citrate?

The SERM medication Enclomiphene Citrate is a trans isomer of Clomiphene Citrate.

Enclomiphene citrate may increase testosterone levels in men. It does this by raising luteinizing hormone (LH) and follicle-stimulating hormone (FSH) levels. The SERM should be able to achieve this without negatively impacting the semen parameters. 

How Does Enclomiphene Citrate Help With Infertility and Hypogonadism?

The key to this SERM is the single isomer found in Enclomiphene Citrate compared to the mixed isomer in the clomiphene citrate. Studies show that using the Enclomiphene Citrate over a period of time for men who are suffering from hypogonadism increased levels of LH and FSH.

Hypogonadism is explained as low serum testosterone levels that can be the root of some male infertility. The increase in testosterone levels is in direct correlation often to improving the male’s fertility, therefore. 

For the percentage of men who are facing male infertility, finding the root of the problem is key.         

 

 

 Sources:

https://www.healthline.com/health/infertility

https://www.hopkinsmedicine.org/health/conditions-and-diseases/male-infertility

https://www.mayoclinic.org/diseases-conditions/male-infertility/symptoms-causes/syc-20374773 

https://www.nichd.nih.gov/health/topics/menshealth/conditioninfo/infertility 

Treating Male Infertility With Enclomiphene Citrate

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