Treating Male Infertility With Enclomiphene Citrate

According to recent literature, nearly 1 in 10 couples who are having unprotected sex for over a year are facing infertility issues. Of those who are having fertility issues, half are from male-related issues including testosterone deficiency.

Many people assume that if a couple is facing infertility, it’s related to issues with the woman due to the complexity of the female reproductive system and involvement in the gestation process. However, the stats show that isn’t always the case. 

What are the issues related to male infertility and how can it be mitigated? Some science suggests to treat male infertility with Enclomifene, a compound that is used to stimulate testosterone levels in men and is currently used as testosterone replacement therapy. 

What Is Male Infertility?

Male infertility is more common than most couples realize. It’s the male’s inability to provide sperm to attach to the female egg and create gestation. 

Male infertility can result from:

• Low sperm production
• Abnormal sperm function
• Blockages that prevent the delivery of sperm

Symptoms of male infertility are pretty rare, except for the inability to conceive a child.

However, some males suffer from underlying conditions that can create the side effects of male infertility. Some of these conditions include:

• An inherited disorder
• Dilated veins around the testicle
• Hormonal imbalance
• A condition that blocks the passage of sperm

What signs and symptoms should you watch out for if you’re struggling to conceive? 

Some men will struggle with their sexual function. This might include trouble ejaculating or very small amounts of fluid during ejaculation. Men might feel reduced sexual desire or difficulty maintaining an erection .

Men may have swelling, pain, or a lump in the testicle area. This would be something to see your doctor about right away. At the same time, your doctor can test your sperm levels.

Non-sex-related symptoms might also include difficulty with smell, recurring respiratory infections, and abnormal breast growth which is often characterized by men with secondary hypogonadism. Hypogonadism occurs with low serum testosterone levels. Some men may even show a decrease in facial or body hair. Other signs of hormonal abnormalities should be documented.

Diagnosis of Male Infertility

The inability to conceive a child can be frustrating. If you’re concerned you may have an issue with male infertility, what should you do? First, remember it can take time to conceive a child. 

You should get a physical to make sure you’re in good health. You should also go a year of having unprotected sex before you have any real need to start investigating.

Having said that, if you have any of the following warning signs, it might be time to see your doctor sooner. Symptoms might include:

• Erectile dysfunction or ejaculation problems
• Partner over 35 years of age
• A lump or swelling in the testicle area
• Pain in the testicle area
• A history of testicle, prostate, or sexual problems
• A groin, testicle, penis, or scrotum surgery

If you’re concerned about male infertility, again start with a regular physical. Then you and your partner should see a fertility specialist.  The specialist can look at both of you to consider potential causes. 

The doctor will start with a general examination and a sperm analysis to test the current sperm counts to ensure they are in a normal range. They may even test LH and FSH levels in you and your partner.

Treating Male Infertility

The first thing a fertility specialist will want is a good analysis of sperm counts. Then they will begin to look at what’s causing the sperm problem and infertility issue if there is one to address.

There are a variety of tests that could be done to evaluate infertility:

• Scrotal ultrasound
• Transrectal ultrasound
• Hormone testing
• Post-ejaculation urinalysis
• Genetic tests
• Testicular biopsy

Treatment for infertility will vary depending on the issue causing infertility. Sometimes it means surgery to address a blockage. Other times individuals will buy Kisspeptin 10 or HCG to attempt to kick start their body’s fertility. The safest and most reliable solution is to see a medical provider. Often it means treating a hormonal condition such as testosterone replacement, or testosterone therapy. Enclomiphene, Kisspeptin-10 and HCG are just a number of different products aimed at improving fertility and still awaiting conclusive results for safety and efficacy.

What Are SERMs?

Enclomifene Citrate is one new treatment for male infertility. It’s a SERM or Selective Estrogen Receptor Modulator. A SERM is a medication that is used to either stimulate or block female estrogen receptors . 

SERMs are used for a variety of health conditions including as part of treatments for breast cancer and osteoporosis. SERMs are often used for postmenopausal women. One SERM, clomifene citrate or Clomid, is also used to stimulate ovulation for women facing infertility. 

SERMs are used to combat hypogonadal men by stimulating testosterone production and fertility. Clomiphene citrate is the most common choice, but Enclomifene citrate is a new product available for this purpose. 

What Is Enclomifene Citrate?

The SERM medication, Enclomifene Citrate, is a trans isomer of Clomifene Citrate. Enclomifene citrate may increase testosterone levels in men by raising luteinizing hormone (LH) and follicle-stimulating hormone (FSH production) levels. The SERM should be able to achieve this without negatively impacting the semen parameters.