High Quality Kisspeptin 10 for sale online
Kisspeptin is a hormone signaling protein naturally produced in humans. In the brain, kisspeptin signaling controls hormone secretion related to the human reproduction system.
Scientists are actively studying how kisspeptin impacts testosterone levels and sex-related behaviors, including factors such as sexual drive and motivation.
Kisspeptin 10 and Regulation of Testosterone Levels
Normalization of Sex Hormones
Certain forms of kisspeptin have been found to alter the regular release of LH in men, helping to normalize sex hormone levels. Administration of kisspeptin-10 to healthy men resulted in increased LH and testosterone levels. However, at high doses, kisspeptin-10 can cause a disruption leading to continuous LH release.
Kisspeptin 10 and Energy Balance and Reproduction
Kisspeptin production and release play a role in energy levels and may regulate energy balance. Studies on mice with the kisspeptin receptor (Kiss1r) removed have shown higher fat tissue and reduced energy levels.
This is because kisspeptin receptors are found in white and brown fat tissue, which further suggests a connection between kisspeptin and energy balance. The interplay between energy levels and reproductive health indicates the involvement of kisspeptin in energy modulation during reproduction.
Anti-Cancer Properties of Kisspeptin-10
Suppression of Melanoma Spread
Kisspeptin is able to suppress the spread of melanoma; a malignant form of skin cancer. It does this by reducing the ability of cancer cells from cell bonding and preventing cancer cells from invading other tissues.
This aids in reducing cancer cell migration. Decreased kisspeptin levels have been found in various metastatic cancer types, including breast, bladder, gastrointestinal, prostate, pancreatic, ovarian, skin, and thyroid cancers.
Connection with Melatonin and Cancer Prevention
An experiment in 2020 revealed a connection between kisspeptin, melatonin, and cancer prevention. Mice exposed to daylight showed high kisspeptin levels and low melatonin levels compared to mice kept in the dark.
Despite the daylight-exposed mice exhibiting high tumor growth rates and volume, there was no metastasis observed. This study supports the potential of melatonin and kisspeptin to suppress tumors.
Kisspeptin 10 Cognitive Effects and Behavior
Kisspeptin influences areas of the brain responsible for memory consolidation and 3-D space orientation. Administration of kisspeptin peptides to mice has been shown to reverse learning and navigational impairment associated with alcohol intoxication.
Additionally, studies have demonstrated that kisspeptin administration to healthy heterosexual men enhances limbic brain activity, leading to increased reward-seeking behavior, drive, and improved overall mood.
Role of Kisspeptin-10 in Kidney Health and Development
Kisspeptin and its receptor are found in several locations throughout the kidney. They have an important role in kidney health and development by influencing kidney function signaling. In mice, Kisspeptin was able to enhance the growth of nerves and blood vessels within the kidney.
Furthermore, kisspeptin may control blood vessel function in specific areas of the body, such as the heart, and potentially contribute to reducing tumor metastasis.
Interactions Between Kisspeptins & Neurokinin B
Kisspeptin and neurokinin B (NKB), encoded by Kiss1 and TAC3/Tac2 genes, govern crucial reproductive milestones like puberty onset. Dysfunctional genes or kisspeptin receptors linked to these neuropeptides result in sexual maturation issues and infertility in both humans and rodents.
These neuropeptides, along with dynorphin A, are co-expressed in the arcuate nucleus as KNDy neurons, where NKB’s stimulatory effects on LH release, mediated by auto-synaptic inputs, induce gonadotropin-releasing hormone GnRH secretion in a kisspeptin-dependent manner.
Data on our Kisspeptin 10 for sale
CAS Number: 374675-21-5
Formula: C63H83N17O14
Sequence: Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe
Molar Mass: 1302.45 g/mol
Class: Decapeptide
Storage: Keep refrigerated upon reconstitution.
- Lyophilized sample in sterile glass vial.
- Minimum 99.5% pure.
- 5mg Kisspeptin 10 peptide per vial.
- Diluent and laboratory supplies not included.
This preparation is for in vitro laboratory research purposes only by licensed professionals and is not approved by the FDA for bodily introduction of any kind into humans or animals. Kisspeptin 10 peptide is not a drug, food, supplement, or cosmetic and may not be misbranded, misused, or mislabeled as a drug, food, supplement or cosmetic.
Kisspeptin Peptide FAQs
What does Kisspeptin-10 do?
Kisspeptin 10 stimulates gonadotropin release in males and also in females during the preovulatory phase of the menstrual cycle, but not the follicular phase.
How much does Kisspeptin-10 increase testosterone?
Kisspeptin 10 infusion at 4μg/kg/hr for 22.5 hours increased serum testosterone by 50% in female and male test subjects.
Is Kisspeptin 10 a natural indicator of pregnancy?
Clinical data shows that Kisspeptin 10 measurement may have higher accuracy that hCG in differentiating between miscarriage and viable pregnancy after 6 weeks of gestation.
What is the role of kisspeptin 10 in the activation of gonadotropin-releasing hormone GnRH neurons?
Kisspeptin 10 is a potent stimulator of GnRH neurons, acting through the G protein-coupled receptor GPR54. Kisspeptin signalling increases the excitability of GnRH neurons and promotes the release of GnRH into the portal circulation.
GnRH then travels to the anterior pituitary gland, where it stimulates the secretion of the gonadotropins luteinizing hormone (LH) and follicle-stimulating hormone (FSH). LH and FSH are essential for the development and function of the gonads and for the production of sex hormones.
How does kisspeptin 10 signaling affect the development and progression of central precocious puberty (CPP)?
Kisspeptin 10 signaling is thought to play a role in the development and progression of CPP by activating GnRH neurons and stimulating the release of gonadotropins. This can lead to early gonadal development and the onset of puberty at a young age.
CPP can have a negative impact on a child’s physical and emotional development, so it is important to understand the underlying mechanisms of the condition and how it can be treated.
What are the potential therapeutic applications of kisspeptin 10 analogues?
Kisspeptin 10 analogues are synthetic versions of kisspeptin 10 that are being developed for use as therapeutic agents. They have the potential to be used to treat a variety of conditions, including:
- Hypogonadotropic hypogonadism: A condition in which the pituitary gland does not produce enough gonadotropins.
- Infertility: A condition in which a couple is unable to conceive naturally.
- Central precocious puberty: A condition in which children enter puberty prematurely.
Kisspeptin 10 analogues may also be used to treat other conditions, such as delayed puberty, menstrual cycle disorders, and menopause. However, more research is needed to confirm the safety and efficacy of kisspeptin 10 analogues for these conditions.
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References:
1. Dhillo WS, Chaudhri OB, Patterson M, Thompson EL, Murphy KG, Badman MK, McGowan BM, Amber V, Patel S, Ghatei MA, Bloom SR. Kisspeptin-54 stimulates the hypothalamic-pituitary gonadal axis in human males. J Clin Endocrinol Metab. 2005 Dec;90(12):6609-15. doi: 10.1210/jc.2005-1468. Epub 2005 Sep 20. PMID: 16174713.
2. George JT, Veldhuis JD, Roseweir AK, Newton CL, Faccenda E, Millar RP, Anderson RA. Kisspeptin-10 is a potent stimulator of LH and increases pulse frequency in men. J. Clin Endocrinol Metab. 2011 Aug;96(8):E1228-36. doi: 10.1210/jc.2011-0089. Epub 2011 Jun 1. PMID: 21632807; PMCID: PMC3380939.
3. Harter CJL, Kavanagh GS, Smith JT. The role of kisspeptin neurons in reproduction and metabolism. J Endocrinol. 2018 Sep;238(3):R173-R183. doi: 10.1530/JOE-18-0108. PMID: 30042117.
4. Mead EJ, Maguire JJ, Kuc RE, Davenport AP. Kisspeptins: a multifunctional peptide system with a role in reproduction, cancer and the cardiovascular system. Br J Pharmacol. 2007 Aug;151(8):1143-53. doi: 10.1038/sj.bjp.0707295. Epub 2007 May 21. PMID: 17519946; PMCID: PMC2189831.
5. Ly T, Harihar S, Welch DR. KISS1 in metastatic cancer research and treatment: potential and paradoxes. Cancer Metastasis Rev. 2020 Sep;39(3):739-754. doi: 10.1007/s10555-020-09868-9. PMID: 32152912; PMCID: PMC7483209.
6. Pazarci P, Kaplan H, Alptekin D, Yilmaz M, Lüleyap U, Singirik E, Pelit A, Kasap H, Yegani A. The effects of daylight exposure on melatonin levels, Kiss1 expression, and melanoma formation in mice. Croat Med J. 2020 Feb 29;61(1):55-61. doi: 10.3325/cmj.2020.61.55. PMID: 32118379; PMCID: PMC7063558.
7. Gibula-Tarlowska E, Kotlinska JH. Kissorphin improves spatial memory and cognitive flexibility impairment induced by ethanol treatment in the Barnes maze task in rats. Behav Pharmacol. 2020 Apr;31(2&3):272-282. doi: 10.1097/FBP.0000000000000557. PMID: 32168027.
8. Comninos AN, Wall MB, Demetriou L, Shah AJ, Clarke SA, Narayanaswamy S, Nesbitt A, Izzi-Engbeaya C, Prague JK, Abbara A, Ratnasabapathy R, Salem V, Nijher GM, Jayasena CN, Tanner M, Bassett P, Mehta A, Rabiner EA, Hönigsperger C, Silva MR, Brandtzaeg OK, Lundanes E, Wilson SR, Brown RC, Thomas SA, Bloom SR, Dhillo WS. Kisspeptin modulates sexual and emotional brain processing in humans. J Clin Invest. 2017 Feb 1;127(2):709-719. doi: 10.1172/JCI89519. Epub 2017 Jan 23. PMID: 28112678; PMCID: PMC5272173.
9. Dudek M, Ziarniak K, Sliwowska JH. Kisspeptin and Metabolism: The Brain and Beyond. Front Endocrinol (Lausanne). 2018 Apr 16;9:145. doi: 10.3389/fendo.2018.00145. PMID: 29713310; PMCID: PMC5911457.
10. Ciaramella V, Della Corte CM, Di Mauro C, Tomassi S, Di Maro S, Troiani T, Martinelli E, Bianco R, Cosconati S, Pierantoni R, Meccariello R, Chianese R, Ciardiello F, Morgillo F. Antitumor efficacy of Kisspeptin in human malignant mesothelioma cells. Oncotarget. 2018 Apr 10;9(27):19273-19282. doi: 10.18632/oncotarget.25018. PMID: 29721201; PMCID: PMC5922395.
11. Jayasena CN, Nijher GM, Comninos AN, Abbara A, Januszewki A, Vaal ML, Sriskandarajah L, Murphy KG, Farzad Z, Ghatei MA, Bloom SR, Dhillo WS. The effects of kisspeptin-10 on reproductive hormone release show sexual dimorphism in humans. J Clin Endocrinol Metab. 2011 Dec;96(12):E1963-72. doi: 10.1210/jc.2011-1408. Epub 2011 Oct 5. PMID: 21976724; PMCID: PMC3232613.
12. Hu KL, Chen Z, Deng W, Li X, Ju L, Yang H, Zhang H, Mu L. Diagnostic Value of Kisspeptin Levels on Early Pregnancy Outcome: a Systematic Review and Meta-analysis. Reprod Sci. 2022 Dec;29(12):3365-3372. doi: 10.1007/s43032-022-00856-8. Epub 2022 Feb 25. PMID: 35212930.
13. Ahmed, A. E., Saito, H., Sawada, T., Yaegashi, T., Yamashita, T., Hirata, T. I., … & Hashizume, T. (2009). Characteristics of the stimulatory effect of kisspeptin-10 on the secretion of luteinizing hormone, follicle-stimulating hormone and growth hormone in prepubertal male and female cattle. Journal of Reproduction and Development, 55(6), 650-654.
14. Zhang, C., Roepke, T. A., Kelly, M. J., & Rønnekleiv, O. K. (2008). Kisspeptin depolarizes gonadotropin-releasing hormone neurons through activation of TRPC-like cationic channels. Journal of Neuroscience, 28(17), 4423-4434.
15. Han SY, McLennan T, Czieselsky K, Herbison AE. Selective optogenetic activation of arcuate kisspeptin neurons generates pulsatile luteinizing hormone secretion. Proc Natl Acad Sci U S A. 2015 Oct 20;112(42):13109-14. doi: 10.1073/pnas.1512243112. Epub 2015 Oct 6. PMID: 26443858; PMCID: PMC4620857.
16. Gottsch ML, Clifton DK Steiner RA. Kisspepeptin-GPR54 signaling in the neuroendocrine reproductive axis. Mol Cell Endocrinol. 2006 Jul 25;254-255:91-6. doi: 10.1016/j.mce.2006.04.030. Epub 2006 Jun 8. PMID: 16762492.
17. Navarro VM. Interactions between kisspeptins and neurokinin B. Adv Exp Med Biol. 2013;784:325-47. doi: 10.1007/978-1-4614-6199-9_15. PMID: 23550013; PMCID: PMC3858905.
