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Could RU-58841 Be the Answer for Hair Loss?

Table of Contents
RU 58841 for Hair Loss

Introduction

RU-58841classified as a Selective Androgen Receptor Modulator (SARM), operates as a topical spray designed to counteract androgen-induced hair loss and acne. Currently, it is under investigation for its potential in the treatment of alopecia

Researchers have directed their attention towards males, especially those with elevated testosterone levels, who commonly contend with issues such as acne and male pattern baldness. This specialized topical spray is the subject of research aimed at obstructing the derivatives of testosterone responsible for hair loss and alopecia.

RU-58841 has proven in recent studies to be one of the top preventers of hair loss and acne, through controlled studies that demonstrate its effectiveness. RU-58841 is presently only approved for laboratory research use and is not sold for consumers.

Male Hair Loss

Men produce testosterone which is a highly active androgen that stimulates hair loss. Research shows that overproduction of testosterone can lead to a byproduct known as dihydro-testosterone (DHT).

When testosterone is converted to DHT, it goes directly to the hair follicles (HF) and binds to the receptors, disrupting the HF’ normal functions and restricting them from producing strong and healthy hair.

DHT also contributes to hair loss by inhibiting proper intake of vitamins, nutrients, minerals, proteins, and antioxidants, making current hair much shorter, weaker, and more brittle.

A diet deficient in vitamins and nutrients can exacerbate hair loss caused by excess testosterone. The hormonal changes that occur due to testosterone production can also lead to increased acne – but RU-58841 may help according to recent studies.

Effects of RU58841 on Rats

Among a new series of N-substituted aryl hydantoins or thiohydantoins, the non-steroidal antiandrogens, RU 58841 and RU 56187, were used in several studies notable for their high activity.

The pharmacokinetics and primary metabolic profiles of these compounds have been evaluated in rat plasma after the administration of using RU58841 intravenously.

Both compounds disappeared relatively quickly from the plasma, with an elimination half-life of approximately 1 hour.

However, they share a common metabolite, the N-desalkyl derivative RU 56279, which is eliminated over the long term. The percentage of each compound that is transformed into RU 56279 was estimated to be 1% and 77%, respectively, based on the AUCs of the metabolite compared with the AUC obtained after administration of RU 56279 itself.

In addition, the in vivo activity of the compounds, as well as that of their metabolites were assessed. This was in respect to the parameters related to systemic anti-androgen effects, such as prostate and seminal vesicle weights.

The systemic effects indicated that the common metabolite, RU 56279, is clearly antiandrogenic. Furthermore, there appears to be a correlation between the percentage formation of this metabolite and the systemic anti androgenic activity of the compounds.

It can therefore be concluded that the pharmacological profile of RU58841, which exhibits a potent local antiandrogenic activity without systemic effects, is likely due to its low propensity to form the N-desalkyl metabolite.

This was the first study of many to test these compounds, where more in-depth RU58841 results should be studied in the future by researchers and scientists alike to gain better insight into these compounds.

5 Key Points About RU-58841’s Effect on Hair Loss Research

Men who experience baldness, receding hairlines, and hair loss may be able to rejuvenate their HF through topical RU-58841 as indicated by clinical research.

The potential benefits of RU-58841 researchers are studying for men suffering from hair loss and acne are as follows:

DHT

RU-58841 is an anti-androgenic compound, meaning it counteracts the effects of DHT, including acne and hair loss. It works by inhibiting androgen receptors from binding to the HF, which would prevent hair from growing.

By inhibiting the androgen receptors from binding to the HF, the hair is empowered to go through its normal growth cycle.

Damaged Hair Follicles

RU-58841’s ability to aid in cell recovery and its effects on damaged HF to return to their normal anagen phase is being studied on how it affects hair growth.

Production of Testosterone

Topical RU-58841 does not interfere with the synthesis of DHT and testosterone. It primarily inhibits their effects on the hair follicles and hair growth effects are being studied along with this.

Effect on Erectile Dysfunction

RU-58841 is being tested for its effects related to erectile dysfunction. 

Difference Compared to Finasteride

RU-58841’s efficacy over other more well-known topical solutions for hair loss, such as finasteride, is being studied. 

How RU can affect androgenic alopecia is being studied

Overall, RU-58841 protects the hair follicles from the effects of DHT without significantly interfering with the body’s natural processes. Those experiencing male pattern baldness may experience quality results with RU-58841 once it is approved by the FDA.

How is Hair Loss Affected?

Finasteride is a commonly used treatment for hair loss. However, when treating alopecia, studies have shown that RU-58841 is more favorable over finasteride.

It completes this by RU-58841 suppressing DHT-induced hair follicle complications more effectively. This reduces the DHT levels in the body. Proper DHT levels can promote heart health, proper sexual function, memory, and blood sugar control, among other benefits.

On the other hand, finasteride is often associated with side effects such as erectile dysfunction, low libido, swelling, depression, and muscular weakness.

RU-58841 works by protecting the hair growth from where the DHT attachment is. This occurs in the areas where the solution is applied topically, as it leaves the rest of the body alone. 

Does RU-58841 Combat Hair Loss?

Research has shown RU-58841’s potential for restoring hair growth and promoting and rejuvenation.  According to studies, test subjects who are experiencing alopecia or androgenic alopecia typically apply RU-58841 as a daily topical spray to the areas of needed hair regrowth.

More clinical trials are needed from researchers to expand knowledge on this compounds ability to provide sufficient hair treatment and hair regrowth. This product is only approved for clinical research and is not sold for human consumption.

In the above studies, skin irritation was not mentioned or studied. 

Learn More from an Expert on SARMs

RU-58841 is an excellent SARM that needs to be studied surrounded hair loss treatment. To learn more about SARMs and RU-58841, contact Sports Technology Labs today for practical, scientifically backed information. 

Abuse Warning

RU-58841 is an investigational compound still awaiting FDA approval and are not dietary supplements. At Sports Technology Labs we are chemical suppliers, not medical doctors, and our expertise is sourcing and quality control.
 
Sports Technology Labs does not encourage or condone consumer use of SARMs products, they are for research purposes only. Anecdotal reports and guides may not match those used in carefully designed medical research protocols and may pose a serious risk of adverse effects in users.
 
Individual variables, comorbidities, and polypharmacy can also contribute significantly to the risk of health problems.

RU58841 and Sports Technology Labs

For the most popular suppliers of RU58841, look no further than the company called Sports Technology Labs.  RU58841 is available in a powder or liquid solution.
 

All pre made solutions of liquid bottle formulations and powder are FDA approved for research purposes only and should only be purchased by research institutions, qualified healthcare provider (s), and those with proper licensing to conduct research that contain these products.

Sign up to our email list for exclusive content, updates, and to be able to apply RU58841 coupons today to your order for 10% off. Many chemists have used this coupon already, so don’t miss out!

Scientific References:

1. B De Brouwer 1, C Tételin, T Leroy, A Bonfils, D Van Neste, A controlled study of the effects of RU-58841, a non-steroidal antiandrogen, on human hair production by balding scalp grafts maintained on testosterone-conditioned nude mice, Journal of Dermatological Science, Volume 137, Issue 5, Nov. 1997, Pages 699-702,

2. T Battmann, A Bonfils, C Branche, J Humbert, F Goubet, G Teutsch, D Philibert, RU 58841, a new specific topical antiandrogen: a candidate of choice for the treatment of acne, androgenetic alopecia and hirsutism, The Journal of Steroid Biochemistry and Molecular Biology, Volume 48, Issue 1, Jan. 1994, Pages 55-60

3. https://www.hairguard.com/ru58841-study-results/

4. Cousty-Berlin, D., Bergaud, B., Bruyant, M. C., Battmann, T., Branche, C., & Philibert, D. (1994). Preliminary pharmacokinetics and metabolism of novel non-steroidal antiandrogens in the rat: relation of their systemic activity to the formation of a common metabolite. The Journal of Steroid Biochemistry and Molecular Biology51(1-2), 47-55.

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