YK-11 is a Selective Androgen Receptor Modulator (SARM) that functions as a gene-specific agonist of the androgen receptor (AR) in MDA-MB 453 cells. The way YK-11 operates is unique, affecting various anabolic pathways. It has been found to display more significant anabolic activity in vitro in C2C12 myoblasts than dihydrotestosterone (DHT).
YK-11 Powder FAQs
Similar to other Selective Androgen Receptor Modulators (SARMs), lab-tested YK-11 demonstrates a dose-dependent reduction in natural testosterone levels in males.
According to available data, YK-11 functions as a myostatin inhibitor by suppressing myostatin through modulation of the follistatin pathway.
Research studies propose that YK-11 induces the expression of osteoblast-specific differentiation markers, including osteoprotegerin and osteocalcin.
This suggests a potential role in facilitating the production of bone tissue and, consequently, contributing to enhanced bone growth.
Why is Sports Technology Labs the best place to buy YK-11 powder online?
It’s not hard to find YK-11 for sale online. Still, Sports Technology Labs is the best place to buy YK-11 powder online because of their consistent, verifiable, high-quality, fast shipping, and their outstanding customer service.
At Sports Technology Labs, you can find the highest quality YK-11 powder for sale anywhere on the internet. We are a U.S.-based business, and our products are tested in U.S.-based third-party laboratories that certify a minimum 98% purity.
That’s why we’re confident in our claim that we offer the best YK-11 powder for sale on the market today.
For orders totaling $149 or more, we offer free shipping. If you’re in a hurry to receive your products, we also provide express shipping options. Additionally, customers who sign up for our email list receive a 10% discount and an additional 10% off when paying with cryptocurrency.
And if you have any questions about our liquid YK-11 products, you can also contact us, and we’ll respond as soon as possible. You can also buy YK-11 in liquid form.
Additional information
Weight
0.25 oz
Dimensions
3 × 0.3 × 4 in
YK-11
Each batch is bottled and tested in the USA to ensure accuracy and purity. Our Certificates of Analysis confirm that products meet the listed specifications:
The way YK-11 promotes muscle growth and key myogenic regulatory factors in skeletal muscle tissue is of particular interest. Factors such as myogenic differentiation factor (MyoD) and myogenic factor 5 (Myf5) are activated to a much greater extent than by DHT. This helps explain why YK-11 exerts its selective modulation of the AR.
Unlike testosterone and most other agents mediated by androgen receptors that promote anabolic growth, YK-11 can be taken orally, meaning injections are not necessary for proper absorption. It’s important to note that YK-11 is currently intended for laboratory research use only, and its side effects are not yet fully understood.
Follistatin Effects on Muscles
What differentiates YK-11 from other SARMs is a key aspect of its anabolic activity that is modulated via the expression of follistatin. This was uncovered by measuring the difference in effects when co-administering anti-follistatin antibodies with YK-11.
Follistatin has been demonstrated to boost insulin-stimulated glucose and amino acid uptake into skeletal muscle cells, which in turn enhances insulin sensitivity and increases skeletal muscle mass. Follistatin proteins also serve the crucial function of blocking inhibitory ligands from binding to Transforming Growth Factor-ß.
Perhaps one of the most exciting aspects of follistatin’s action is its binding and neutralization of catabolic proteins like Activin A, Activin B, and Myostatin. A significant challenge is that follistatin proteins themselves are quickly broken down through proteolysis and have limited bioavailability and half-life, even with direct injection into wasting muscles.
YK-11, however, stimulates the body to produce more follistatin proteins both systemically and locally. This may circumvent the limitations of direct follistatin administration and contribute to muscle growth.
YK-11 Applications
In summary, YK-11 stands out in the world of SARMs, demonstrating unique anabolic effects. Its ability to selectively modulate the AR and enhance follistatin expression holds promising potential.
Yet, a comprehensive understanding and application of YK-11 remain in the realm of research, and further studies are needed to fully grasp its potential benefits and risks, particularly regarding human applications.
Abuse Warning
YK-11 is an investigational compound still awaiting FDA approval and is not a dietary supplement. At Sports Technology Labs, we are chemical suppliers, not medical doctors, and our expertise is sourcing and quality control.
Sports Technology Labs does not encourage or condone consumer use of SARMs products; they are for research purposes only.
SARMs should only be used under the supervision and direction of a medical doctor or designated research authority. We strongly discourage the use of SARMs for performance enhancement in sports and bodybuilding, and warn against “bro science” and peer consensus when making decisions about health.
YK-11 Scientific References:
1. Kanno Y, Hikosaka R, Zhang SY, Inoue Y, Nakahama T, Kato K, Yamaguchi A, Tominaga N, Kohra S, Arizono K, Inouye Y (2011). “(17α,20E)-17,20-[(1-methoxyethylidene)bis(oxy)]-3-oxo-19-norpregna-4,20-diene-21-carboxylic acid methyl ester (YK-11) is a partial agonist of the androgen receptor”. Biological & Pharmaceutical Bulletin. 34 (3): 318–23. PMID 21372378 https://pubmed.ncbi.nlm.nih.gov/21372378/
2. Kanno Y, Ota R, Someya K, Kusakabe T, Kato K, Inouye Y (2013). “Selective androgen receptor modulator, YK-11, regulates myogenic differentiation of C2C12 myoblasts by follistatin expression”. Biological & Pharmaceutical Bulletin. 36 (9): 1460–5. PMID 23995658.
3. Han X, Moller LLV, et al. Mechanisms involved in follistatin-induced hypertrophy and increased insulin action in skeletal muscle. J Cachexia Sarcopenia Muscle. 2019 Aug 11.
4. Castonguay R, Lachey J, Wallner S, et al. Follistatin-288-Fc Fusion Protein Promotes Localized Growth of Skeletal Muscle. J Pharmacol Exp Ther. 2019 Mar;368(3):435-445. doi: 10.1124/jpet. 118.252304. Epub 2018 Dec 18.
