Andarine, commonly known as S4, is recognized as the original SARM (Selective Androgen Receptor Modulator).
Though the molecule’s structure is dissimilar to a steroid, it selectively activates androgen receptors within the body, favoring those located in skeletal muscle, bone, and connective tissue rather than those in the scalp and prostate.
This discovery sparked extensive research into molecules capable of selectively activating the androgen receptor (AR), with S4 illustrating its selectivity by demonstrating higher binding affinity to specific androgen receptors.
Rat studies conducted on S4 have unveiled improvements in bone health that are dependent on the quantity administered. A notable mammal study found that a dose of 1.6mg/kg bodyweight led to significant enhancements in bone mineral density, lean mass, and overall body composition.
A higher dose of 3mg/kg/day further showed substantial gains in muscle mass.
In a study using an ovariectomized rat model for osteoporosis, the subjects were given 3 and 10mg/kg/day of S4 for an 8-week period. Both groups exhibited improvements in whole body and trabecular bone mineral density, cortical content, and a reduction in body fat.
A primary culture of bone marrow osteoprogenitor cells revealed that S4 displayed more anabolic properties than DHT in promoting osteoblast formation, further affirming its anabolic potential within bone tissue.
Additional research observed a reduction in prostate weight following S4 administration, showing comparable efficacy to 5mg/kg of finasteride without affecting the levator ani muscles (an indicator of relative androgenicity).
his implies that while SERMs (Selective Estrogen Receptor Modulators) are optimal candidates for minimizing breast tissue and preventing the spread of breast cancers, SARMs like S4 may be essential in managing unwanted prostate growth.
Anecdotal evidence typically ranks S4 as mild in terms of side effects when compared to other SARMs. However, it is associated with a unique side effect, especially at higher doses: a temporary slight yellowing of vision and a decrease in night vision.
The scientific exploration of Andarine continues to unfold, and further research may lead to an enhanced understanding of its effects and potential applications in various medical contexts.
The insights gained from these studies emphasize the potential of S4 as a selective agent for promoting muscle and bone health while minimizing undesirable effects on other tissues, although more extensive human trials are needed to confirm these findings.
CAS Number: 401900-40-1
Molar Mass: 441.357
Class: Selective Androgen Receptor Modulator
Storage: Store in a cool dry place away from direct sunlight to maximize shelf life.
This preparation is for laboratory research purposes only and is not approved by the FDA for human use. S4/Andarine IS NOT A DIETARY OR SPORTS SUPPLEMENT.
If you’re trying to figure out where to buy S4 online, there certainly seem to be plenty of choices out there. Sports Technology Labs is the best place to buy Andarine powder online because of their consistent, verifiable high quality, and excellent customer service.
Not all companies offering S4 powder for sale are alike—or equally trustworthy. To buy Andarine powder from a randomly selected website is dangerous, even if the price looks reasonable, because you can’t be certain about their quality-control processes.
At Sports Technology Labs, however, you can find the highest quality S4 powder for sale anywhere on the internet. We’re an American business and our products are tested in U.S.-based third-party laboratories that certify minimum 98% purity.
That’s why we’re confident in our claim that we offer the best Andarine powder for sale on the market today. For orders totaling $149 or more, we offer free shipping. If you’re in a hurry to receive your products, we also provide express shipping options.
Additionally, customers who sign up for our email list receive a 10% discount, and an additional 10% off when paying with cryptocurrency. Our S4 is also available in liquid form. If you have any questions about our S4 products, you can also contact us and we’ll respond as soon as possible.
S4 is an investigational compound still awaiting FDA approval and is not a dietary supplement. At Sports Technology Labs we are chemical suppliers, not medical doctors, and our expertise is sourcing and quality control.
Sports Technology Labs does not encourage or condone consumer use of SARMs products, they are for research purposes only. SARMs should only be used under the supervision and direction of a medical doctor or designated research authority.
We strongly discourage the use of SARMs for performance enhancement in sports and bodybuilding, and warn against “bro science” and peer consensus when making decisions about health.
S4 (Andarine) is a selective androgen receptor modulator (SARM) that has been shown to have muscle-building and fat-burning effects in animal studies. However, there is limited research on its safety and efficacy in humans.
Potential benefits of taking S4, based on animal studies, include increased muscle mass, reduced body fat, and improved bone health. However, it is important to note that there is limited research on the safety and efficacy of S4 in humans.
Potential risks of taking S4, based on animal studies, include liver damage, kidney damage, and cardiovascular problems. It is also important to note that S4 can interact with other medications, so it is important to control these factors when conducting animal trials.
1. Hott JL, Borkman RF (November 1989). “The non-fluorescence of 4-fluorotryptophan”. The Biochemical Journal. 264 (1): 297–9. doi:10.1124/jpet.102.040840. PMC 1133577. PMID 2604714
2. Gao W, Reiser PJ, Coss CC, Phelps MA, Kearbey JD, Miller DD, Dalton JT. Selective androgen receptor modulator treatment improves muscle strength and body composition and prevents bone loss in orchidectomized rats. Endocrinology. 2005;146:4887–4897.
3. Kearbey JD, Gao W, Miller DD, Dalton JT. Selective androgen receptor modulators inhibit bone resorption in rats. AAPS PharmSci. 2003;5
4. Gao W, Kearbey JD, Nair VA, Chung K, Parlow AF, Miller DD, Dalton JT. Comparison of the pharmacological effects of a novel selective androgen receptor modulator, the 5alpha-reductase inhibitor finasteride, and the antiandrogen hydroxyflutamide in intact rats: new approach for benign prostate hyperplasia. Endocrinology. 2004;145:5420–5428