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MOTS-c consists of 16 amino acids and is part of a group known as mitochondrial-derived peptides (MDPs). MDPs are bioactive hormones that have major effects on energy regulation, skeletal muscle, and mitochondrial communication.

Research shows that many MDPs including MOTS-c are active in the cell nucleus as well as in the bloodstream. Peptide research shows MOTS-c plays an important role in weight regulation, metabolism, longevity, exercise capacity, skeletal muscle growth, and even processes that lead to disease. The peptide has been researched in the last few years for its therapeutic properties. 

Peptide MOTS c promotes metabolic changes that regulate the way the body uses energy. Studies in mice show that when MOTS c treatment is present, it helps the body break down fat and boost energy levels [1]. This happens by MOTS-c working in the nucleus to change how genes are expressed. When MOTS-c isn’t present, it can lead to increased levels of fat in the bloodstream and a change in how the body regulates energy. This forces the body to boost insulin levels to clear lipids from the bloodstream, which causes the body to become resistant to frequently high levels of insulin [2]. Research in mice that were given MOTS c treatment, showed an increase in brown fat function and a reduction in the buildup of fatty tissue and weight gain, even when fed a high fat diet. During the mots c treatment, the peptide prevented inflammation and fatty tissue build up that typically leads to insulin resistance [3]. Mice Studies also show that MOTS-c can increase the absorption of glucose in muscles by reversing insulin resistance.

MOTS c treatment increases the delivery of glucose carriers by increasing the muscle response to AMP activated protein kinase [4]. The AMPK pathway is activated in ketogenic diets and increases fat metabolism and insulin sensitivity while protecting lean body mass. When cellular energy is low, the AMPK pathway is activated to drive the uptake of glucose and fatty acids by cells for metabolism. Elevated plasma MOTS-c levels can improve muscle function, enhanced muscle growth, and decreased functional insulin resistance. Because the peptide causes AMPK activation that is independent of insulin pathways, MOTS-c can increase glucose uptake by into skeletal muscle even when insulin is low or doesn’t work, suggesting that this peptide may help with body weight, fat mass, obesity and insulin resistance. Recent research shows that the MOTS-c peptide affects nuclear gene expression by leaving the mitochondria and entering the nucleus, thereby regulating genes that are involved in glucose restriction and antioxidant responses after metabolic stress [5]

Research shows elevated MOTS-c levels help promote collagen synthesis and strengthen bones and skeletal muscles by regulating the TGF-beta/SMAD pathway to increase osteoblast survival [6]. The MOTS-c is also responsible for promoting the development of new stem cells within bone marrow from activation of the same TGF-beta/SMAD pathway and creates new bone tissue [7].

Studies have found that a substitution of glutamate residue for the amino acid lysine within the protein is associated with longevity and mitigation of age dependent physical decline and muscle loss in certain human populations, one example is observed in Japan. This substitution would change both the structure and function of the MOTS-c gene because glutamate has very different properties than lysine. This change is exclusively seen in humans with Northeast Asian ancestry and scientists think it may play a role in promoting their longevity [8]. Mitochondrial biology is very important for extending lifespan and increasing the health of humans. Peptides like MOTS-c may make it possible to directly impact mitochondrial function without dietary restriction.

Endothelial cells are found along the lining of blood vessels and play a role in regulating blood pressure, blood clotting, and plaque formation. Studies found that patients with lower levels of MOTS-c in their blood have higher levels of endothelial cell dysfunction. Additional research in rats suggests even though MOTS-c does not affect blood vessel responsiveness, it makes endothelial cells more sensitive to the effects of other signaling molecules, like acetylcholine. Mice fed a high fat diet showed improvement with endothelial function and improved microvascular and epicardial blood vessel function when given MOTS-c [9].

 

Data on our MOTS-c for sale

 

CAS Number: 1627580-64-6

Formula: C101H152N28O22S2

Sequence: H-Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg-OH

Molar Mass:  2174.6 g/mol

Class: Polypeptide

Experimental Application: Weight regulation, metabolism, longevity, exercise tolerance

Storage: Keep refrigerated upon reconstitution.

 

  • Lyophilized sample in sterile glass vial.
  • Minimum 98% pure.
  • 5mg MOTS-c peptide per vial.
  • Diluent and laboratory supplies not included.

 

This preparation is for in vitro laboratory research purposes only by licensed professionals and is not approved by the FDA for bodily introduction of any kind into humans or animals. MOTS-c is not a drug, food, supplement, or cosmetic and may not be misbranded, misused, or mislabeled as a drug, food, supplement or cosmetic. 

 

Why buy MOTS-c from Sports Technology Labs?

 

If you’re trying to figure out where to buy MOTS-c peptides online, there certainly seem to be plenty of choices out there. However, not all companies offering MOTS C for sale are alike—or equally trustworthy. To buy MOTS C  from a randomly selected website is dangerous, even if the price looks reasonable, because you can’t be certain about their quality-control processes, especially when they do not have third party certificates available.

At Sports Technology Labs you can find the highest quality MOTS-c for sale anywhere on the internet. When you buy peptides from Sports Technology Labs you are choosing the highest quality products. Pure compounds tested and certified by accredited American third party labs that accept phone calls to verify the validity of their certificates. Our products come lyophilized in glass bottles and are stored in refrigeration to prevent degradation in storage. We run a transparent business, with no discreet payment methods necessary and no misrepresentation of our products, only the highest quality research chemicals available online, secured by our 60-day money-back guarantee.

That’s why we’re confident in our claim that we offer the best MOTS-C for sale on the market today. And if you have any questions about our MOTS-C and other products, you can also contact us and we’ll respond as soon as possible.

 

References:

 

1. Kim SJ, Miller B, Mehta HH, Xiao J, Wan J, Arpawong TE, Yen K, Cohen P. The mitochondrial-derived peptide MOTS-c is a regulator of plasma metabolites and enhances insulin sensitivity. J Physiol Rep. 2019 Jul;7(13):e14171. doi: 10.14814/phy2.14171. PMID: 31293078; PMCID: PMC6640593.

2. Crescenzo R, Bianco F, Mazzoli A, Giacco A, Liverini G, Iossa S. A possible link between hepatic mitochondrial dysfunction and diet-induced insulin resistance. Eur J Nutr. 2016 Feb;55(1):1-6. doi: 10.1007/s00394-015-1073-0. PMID: 26476631.

3. Lu H, Wei M, Zhai Y, Li Q, Ye Z, Wang L, Luo W, Chen J, Lu Z. MOTS-c peptide regulates adipose homeostasis to prevent ovariectomy-induced metabolic dysfunction. J Mol Med (Berl). 2019 Apr;97(4):473-485. doi: 10.1007/s00109-018-01738-w. Epub 2019 Feb 6. PMID: 30725119.

4. Lee C, Kim KH, Cohen P. MOTS-c: A novel mitochondrial-derived peptide regulating muscle and fat metabolism. Free Radic Biol Med. 2016 Nov;100:182-187. doi: 10.1016/j.freeradbiomed.2016.05.015. Epub 2016 May 20. PMID: 27216708; PMCID: PMC5116416.

5. Kim KH, Son JM, Benayoun BA, Lee C. The Mitochondrial-Encoded Peptide MOTS-c Translocates to the Nucleus to Regulate Nuclear Gene Expression in Response to Metabolic Stress. Cell Metab. 2018 Sep 4;28(3):516-524.e7. doi: 10.1016/j.cmet.2018.06.008. Epub 2018 Jul 5. PMID: 29983246; PMCID: PMC6185997.

6. Che N, Qiu W, Wang JK, Sun XX, Xu LX, Liu R, Gu L. MOTS-c improves osteoporosis by promoting the synthesis of type I collagen in osteoblasts via TGF-β/SMAD signaling pathway. Eur Rev Med Pharmacol Sci. 2019 Apr;23(8):3183-3189. doi: 10.26355/eurrev_201904_17676. PMID: 31081069.

7. Hu BT, Chen WZ. MOTS-c improves osteoporosis by promoting osteogenic differentiation of bone marrow mesenchymal stem cells via TGF-β/Smad pathway. Eur Rev Med Pharmacol Sci. 2018 Nov;22(21):7156-7163. doi: 10.26355/eurrev_201811_16247. PMID: 30468456.

8. Fuku N, Pareja-Galeano H, Zempo H, Alis R, Arai Y, Lucia A, Hirose N. The mitochondrial-derived peptide MOTS-c: a player in exceptional longevity? Aging Cell. 2015 Dec;14(6):921-3. doi: 10.1111/acel.12389. Epub 2015 Aug 20. PMID: 26289118; PMCID: PMC4693465.

9. Qin Q, Delrio S, Wan J, Jay Widmer R, Cohen P, Lerman LO, Lerman A. Downregulation of circulating MOTS-c levels in patients with coronary endothelial dysfunction. Int J Cardiol. 2018 Mar 1;254:23-27. doi: 10.1016/j.ijcard.2017.12.001. Epub 2017 Dec 6. PMID: 29242099.

MOTS-c 5mg

Additional information

Weight 0.25 oz
Dimensions 2 × 1 × 1 in