Selank: A Synthetic Peptide with Demonstrated Research-based Benefits
Selank is a synthetic peptide, equivalent to the naturally occurring Tuftsin, capable of modifying or regulating one or more immune functions. However, Selank is more stable and has a longer half-life.
Research demonstrates Selank not only helps people with generalized anxiety disorder, but can:
- lower stress levels
- improve mood
- promote memory retention and learning.
Selank has a sedative effect like benzodiazepines, however Selank has not been shown to be habit-forming and does not cause withdrawal or amnesia.
Selank Modulation of GABA Signaling Genes
Research in rats shows that Selank modulates GABA signaling genes by increasing the binding affinity of the GABA receptor. By doing this, Selank can alter the expression of nerve cell genes in the nervous system.
Comparison of Selank with Benzodiazepines in Anxiety Disorders
Selank and benzodiazepines have similar effects on anxiety disorders as seen in a recent study conducted on rats. Selank has a small advantage over benzodiazepines when tackling high anxiety levels, but when used in sequence, the two treatments together appear to have the best results for treating chronic mild stress that is unpredictable.
Selank and Inhibition of Enzyme Breakdown and Enkephalin Protection
Selank’s effects are most likely caused by inhibiting the enzyme that breaks down circulating enkephalins and other peptides. People with anxiety and phobic disorders produce more enzymes to break down these peptides, causing the enkephalins in their bloodstream to have shorter half-lives when tested during anxiety.
By resetting this enzymatic pathway, Selank may protect the body’s natural anxiolytic peptides. Research in anxiety-prone mice shows that some of the effects from Selank are caused by the prevention of enkephalin degradation.
Selank and Chronic Fatigue
The effect on pain and fatigue may be because Selank can slow the breakdown of enkephalins, the body’s natural painkillers. When Selank was tested in rats, results demonstrated that the peptide regulates the expression of genes affecting chemokines, cytokines, and receptors for both that are involved with the body’s inflammatory processes.
Selank has specifically been found to alter the expression of the BcI6 gene that is primarily involved in the development of the immune system. Further testing showed Selank temporarily changes C3, CAsp1, Il2rf, and Xcr1 gene expression in the mouse spleen. Selank can change the balance of the immune system and cause modulation of inflammation by affecting these genes.
Memory and Anxiety Changes
It is difficult for the body to store new information and recall memory when experiencing increased anxiety. Anxiety medication can reduce the negative correlation between anxiety and learning/memory, however, Selank appears to boost cognition directly. Research in rats shows that Selank boosts the stability of trace memory and, in turn, causes an increase in the process of memory storage, regardless of the anxiety levels of the rats.
Selank Gene Expression Effects
Selank can do more than simply reduce stress-related impairment of memory. Selank may also increase memory by altering the expression of genes found in the hippocampus. After Selank was administered to rats, there were changes in 36 different genes in mRNA levels. The majority of these genes encode proteins associated with the plasma membrane and can regulate ion-dependent memory and learning processes.
Restoration of Cognitive Processes After Brain Damage
Selank can restore learning and memory after brain damage has occurred. In one study on rats treated with Selank following brain damage induced by a neurotoxin, rats’ cognitive processes were restored. The restorative effects appear to be related to Selank’s ability to cause inhibition of the catecholamine system in the brain.
Anti-Inflammatory Effects and Depression Treatment with Selank
In patients with depression, Selank can suppress the gene that produces an inflammatory cytokine. When studying molecular genetics, this gene suppression does not appear to take place in healthy individuals and is only observed in patients with depression.
Selank may treat these anxiety-related symptoms such as:
- tiredness
- headache
- heart palpitations
- blood pressure increases
- nerve pain
- depression.
Benzodiazepines and Selank show similar benefits in reducing anxiety, but Selank is also able to reduce fatigue and pain.
Data on our Selank for sale
CAS Number: 129954-34-3
Formula: C33H57N11O9
Sequence: Thr-Lys-Pro-Arg-Pro-Gly-Pro
Molar Mass: 811.9 g/mol
Class: Hexapeptide
Storage: Keep refrigerated upon reconstitution.
- Lyophilized sample in sterile glass vial.
- Minimum 98% pure.
- 5mg Selank peptide per vial.
- Diluent and laboratory supplies not included.
This preparation is for in vitro laboratory research purposes only by licensed professionals and is not approved by the FDA for bodily introduction of any kind into humans or animals. Selank peptide is not a drug, food, supplement, or cosmetic and may not be misbranded, misused, or mislabeled as a drug, food, supplement or cosmetic.
Selank FAQs
Selank administration has shown clinical significance in the improvement of learning, memory, cognition, anxiety, depression, immune function, and sleep in test subjects.
Clinical studies have demonstrated that the effect of Selank is similar to that of low doses of tranquilizers, but does not include withdrawal, amnesia, or dependence.
Expression of 22 genes were observed within three hours of Selank administration with some changes occuring in the first hour.
Selank is considered to be a nootropic, anxiolytic peptide.
Why buy Selank peptide from Sports Technology Labs?
If you are trying to figure out where to buy Selank peptide, there are many options out there. To buy Selank from a randomly selected company is dangerous. Most companies with peptides for sale, sad to say, do not test their products or hide their certificates or contact information for their third party labs from customers. What can they be hiding?
At Sports Technology Labs you can find the best Selank for sale anywhere on the internet. When you buy peptides from Sports Technology Labs you are choosing the highest quality ingredients.
The peptides for sale at Sports Technology Labs are pure compounds tested and certified by accredited American third party labs that accept phone calls to verify the validity of their certificates.
Our products come lyophilized in glass bottles and are stored in refrigeration to prevent degradation in storage. We run a transparent business, with no discreet payment methods necessary and no misrepresentation of our products, only the highest quality research chemicals available online, secured by our 60-day money-back guarantee.
Sports Technology Labs is the best place to buy Selank online because of our consistent, verifiable high quality products, safe bottling and packaging, fast shipping, and great customer service. For orders totaling $149 or more, we offer free shipping. If you’re in a hurry to receive your products, we also provide express shipping options. Additionally, customers who sign up for our email list receive a 10% discount, and an additional 10% off when paying with cryptocurrency. And if you have any questions about our Selank and other products, you can also contact us and we’ll respond as soon as possible.
References:
1. Volkova A, Shadrina M, Kolomin T, Andreeva L, Limborska S, Myasoedov N, Slominsky P. Selank Administration Affects the Expression of Some Genes Involved in GABAergic Neurotransmission. Front Pharmacol. 2016 Feb 18;7:31. doi: 10.3389/fphar.2016.00031. PMID: 26924987; PMCID: PMC4757669.
2. Kasian A, Kolomin T, Andreeva L, Bondarenko E, Myasoedov N, Slominsky P, Shadrina M. Peptide Selank Enhances the Effect of Diazepam in Reducing Anxiety in Unpredictable Chronic Mild Stress Conditions in Rats. Behav Neurol. 2017;2017:5091027. doi: 10.1155/2017/5091027. Epub 2017 Feb 9. PMID: 28280289; PMCID: PMC5322660.
3. Zozulya AA, Kost NV, Yu Sokolov O, Gabaeva MV, Grivennikov IA, Andreeva LN, Zolotarev YA, Ivanov SV, Andryushchenko AV, Myasoedov NF, Smulevich AB. The inhibitory effect of Selank on enkephalin-degrading enzymes as a possible mechanism of its anxiolytic activity. Bull Exp Biol Med. 2001 Apr;131(4):315-7. doi: 10.1023/a:1017979514274. PMID: 11550013.
4. Sokolov OY, Meshavkin VK, Kost NV, Zozulya AA. Effects of Selank on behavioral reactions and activities of plasma enkephalin-degrading enzymes in mice with different phenotypes of emotional and stress reactions. Bull Exp Biol Med. 2002 Feb;133(2):133-5. doi: 10.1023/a:1015582302311. PMID: 12432865.
5. Uchakina ON, Uchakin PN, Miasoedov NF, Andreeva LA, Shcherbenko VE, Mezentseva MV, Gabaeva MV, Sokolov OIu, Zozulia AA, Ershov FI. [Immunomodulatory effects of selank in patients with anxiety-asthenic disorders]. Zh Nevrol Psikhiatr Im S S Korsakova. 2008;108(5):71-5. Russian. PMID: 18577961.
6. Zozulia AA, Neznamov GG, Siuniakov TS, Kost NV, Gabaeva MV, Sokolov OIu, Serebriakova EV, Siranchieva OA, Andriushenko AV, Telesheva ES, Siuniakov SA, Smulevich AB, Miasoedov NF, Seredenin SB. [Efficacy and possible mechanisms of action of a new peptide anxiolytic selank in the therapy of generalized anxiety disorders and neurasthenia]. Zh Nevrol Psikhiatr Im S S Korsakova. 2008;108(4):38-48. Russian. PMID: 18454096.
7. Kolomin T, Shadrina M, Andreeva L, Slominsky P, Limborska S, Myasoedov N. Expression of inflammation-related genes in mouse spleen under tuftsin analog Selank. Regul Pept. 2011 Oct 10;170(1-3):18-23. doi: 10.1016/j.regpep.2011.05.001. Epub 2011 May 24. PMID: 21609736.
8. Agapova TIu, Agniullin IaV, Silachev DN, Shadrina MI, Slominskiĭ PA, Shram SI, Limborskaia SA, Miasoedov NF. [Effect of semax on the temporary dynamics of brain-derived neurotrophic factor and nerve growth factor gene expression in the rat hippocampus and frontal cortex]. Mol Gen Mikrobiol Virusol. 2008;(3):28-32. Russian. PMID: 18756821.
9. Semenova TP, Kozlovskiĭ II, Zakharova NM, Kozlovskaia MM. [Experimental optimization of learning and memory processes by selank]. Eksp Klin Farmakol. 2010 Aug;73(8):2-5. Russian. PMID: 20919548.
10. Semenova TP, Kozlovskaya MM, Zakharova NM, Kozlovskii II, Zuikov AV. Effect of selank on cognitive processes after damage inflicted to the cerebral catecholamine system during early ontogeny. Bull Exp Biol Med. 2007 Nov;144(5):689-91. doi: 10.1007/s10517-007-0406-2. PMID: 18683497.
11. Kost NV, Sokolov OIu, Gabaeva MV, Grivennikov IA, Andreeva LA, Miasoedov NF, Zozulia AA. Ingibiruiushchee deĭstvie semaksa i selanka na énkefalindegradiruiushchie fermenty syvorotki krovi cheloveka [Semax and selank inhibit the enkephalin-degrading enzymes from human serum]]. Bioorg Khim. 2001 May-Jun;27(3):180-3. Russian. doi: 10.1023/a:1011373002885. PMID: 11443939.
12. Selank Peptide: Exploring its Potential in Anxiety and Cognitive Enhancement. Peptide Information (2023)
