Delta sleep-inducing peptide (DSIP) is a nine amino acid peptide that has a number of physiological and endocrine roles. DSIP can alter corticotropin levels, improve sleep patterns, normalize blood pressure, inhibit somatostatin secretion, limit stress, and limit pain perception. It may also have applications in prevention of free radical damage, cancer treatment, and depression.
DSIP was first isolated from rabbit brains during slow-wave sleep and has been associated with the regulation of sleep-wake cycles of the central nervous system. However, it has not been discovered how or where DSIP is synthesized within the body. DSIP levels are as high in external tissues as they are in the central nervous system. This finding may suggest that the peptide’s primary function may not involve sleep at all and that it is made outside of the central nervous system. In animal models, DSIP was found to regulate heart rate and blood pressure, improve thermogenesis, and the lymphokine system, indicating that DSIP may play a part in preparing the body for the onset of sleep by altering its physiology .
Research has been conflicting on the mechanism behind the connection between DSIP and sleep patterns, but it is clear that DSIP is in some way related to the onset of sleep. Human Research indicates that DSIP promotes sleep by producing feelings of sleepiness, shortening the onset, and increasing sleep time by 59% compared to placebo. However, the findings are contraindicated by EEGs’ inability to demonstrate sedation . A major research study showed the peptide improves sleep enough to match that of control subjects in patients with chronic insomnia . Studies using polysomnographic equipment showed that DSIP promoted the efficiency of sleep .
It is thought that DSIP may be a hypothalamic hormone that could regulate more than just sleep, similar to how growth hormone regulates more than bone and muscle growth. Studies have shown DSIP was able to restrict the formation of a protein produced in muscle cells called somatostatin, which inhibits muscle growth . DSIP promotes muscle growth and enlargement by inhibiting somatostatin. These effects have led researchers to hypothesize that the peptide may regulate more of human physiology, even though it was originally thought to be only involved in promoting sleep.
Research in rats shows that DSIP may be able to activate opioid receptors to reduce the sensations of pain. The research showed that the peptide could produce a significant, dose dependent, pain-relieving effect . So far, the research indicates that even though opioids and DSIP both act on the same receptors in the CNS (central nervous system), DSIP does not create the level of dependency brought on by opiate medications. A pre-clinical trial in humans demonstrated that DSIP significantly reduced the perception of pain and improved mood. It was also found during this study that DSIP has the ability to reduce the pain rebound and other withdrawal symptoms that often occur after stopping long-term pain therapy, indicating that DSIP may be useful in patients that are physiologically dependent on other pain medications .
Most Cancer research focuses on curing the disease after it has been diagnosed. However, there is a small amount of interest in preventing cancer from developing to begin with. Most preventive research uses cancer vaccines to eliminate cancerous cells before they spread by stimulating the body’s own immune system. Research in mice has shown that DSIP may prevent cancer better than any vaccine tested to date. The mice were given DSIP on a consistent monthly basis until their death, and research found that the subjects injected with DSIP peptide presented 2.6 times lower development of tumors and a 22.6% decrease in chromosomal defects of bone marrow .
Data on our DSIP for sale
CAS Number: 62568-57-4
Molar Mass: 848.81 g/mol
Experimental Application: Sleep quality, tumor prevention, anti aging, addiction treatment, fat loss, narcolepsy, somatostatin inhibition
Storage: Keep refrigerated upon reconstitution.
- Lyophilized sample in sterile glass vial.
- Minimum 98% pure.
- 5mg DSIP peptide per vial.
- Diluent and laboratory supplies not included.
This preparation is for in vitro laboratory research purposes only by licensed professionals and is not approved by the FDA for bodily introduction of any kind into humans or animals. DSIP / Delta Sleep Inducing Peptide is not a drug, food, supplement, or cosmetic and may not be misbranded, misused, or mislabeled as a drug, food, supplement or cosmetic.
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Sports Technology Labs is the best place to buy DSIP online because of our consistent, verifiable high quality products, safe bottling and packaging, fast shipping, and great customer service. That’s why we’re confident in our claim that we offer the best DSIP for sale on the market today. And if you have any questions about our DSIP and other products, you can also contact us and we’ll respond as soon as possible.
1. Yehuda S, Carasso RL. DSIP–a tool for investigating the sleep onset mechanism: a review. Int J Neurosci. 1988 Feb;38(3-4):345-53. doi: 10.3109/00207458808990695. PMID: 3286557.
2. Schneider-Helmert D, Gnirss F, Monnier M, Schenker J, Schoenenberger GA. Acute and delayed effects of DSIP (delta sleep-inducing peptide) on human sleep behavior. Int J Clin Pharmacol Ther Toxicol. 1981 Aug;19(8):341-5. PMID: 6895513.
3. Schneider-Helmert D. Effects of delta-sleep-inducing peptide on 24-hour sleep-wake behaviour in severe chronic insomnia. Eur Neurol. 1987;27(2):120-9. doi: 10.1159/000116143. PMID: 3622582.
4. Bes F, Hofman W, Schuur J, Van Boxtel C. Effects of delta sleep-inducing peptide on sleep of chronic insomniac patients. A double-blind study. Neuropsychobiology. 1992;26(4):193-7. doi: 10.1159/000118919. PMID: 1299794.
5. Koval’zon VM. DSIP: peptid sna ili neizvestnyĭ gormon gipotalamusa [DSIP: the sleep peptide or an unknown hypothalamic hormone?]. Zh Evol Biokhim Fiziol. 1994 Mar-Apr;30(2):310-9. Russian. PMID: 7817664.
6. Nakamura A, Nakashima M, Sugao T, Kanemoto H, Fukumura Y, Shiomi H. Potent antinociceptive effect of centrally administered delta-sleep-inducing peptide (DSIP). Eur J Pharmacol. 1988 Oct 18;155(3):247-53. doi: 10.1016/0014-2999(88)90510-9. PMID: 2853064.
7. Larbig W, Gerber WD, Kluck M, Schoenenberger GA. Therapeutic effects of delta-sleep-inducing peptide (DSIP) in patients with chronic, pronounced pain episodes. A clinical pilot study. Eur Neurol. 1984;23(5):372-85. doi: 10.1159/000115716. PMID: 6548970.
8. Popovich IG, Voitenkov BO, Anisimov VN, Ivanov VT, Mikhaleva II, Zabezhinski MA, Alimova IN, Baturin DA, Zavarzina NY, Rosenfeld SV, Semenchenko AV, Yashin AI. Effect of delta-sleep inducing peptide-containing preparation Deltaran on biomarkers of aging, life span and spontaneous tumor incidence in female SHR mice. Mech Ageing Dev. 2003 Jun;124(6):721-31. doi: 10.1016/s0047-6374(03)00082-4. PMID: 12782416.