Melanotan II 10 mg

 Selling fast! Get yours today  Same-day shipping available

$49.99

In stock

Why this peptide

Key highlights

10 mg lyophilized vialFreeze-dried peptide in a sterile, UV-resistant glass vial.
99.63% HPLC purityEach lot analyzed by an accredited US third-party lab via HPLC and mass spectrometry.
Cold-chain peptideRefrigerate after reconstitution. Diluent and lab supplies not included.
Research use onlySupplied exclusively for laboratory investigation and development.
Technical data

Product specifications

Melanotan II (MT-2) — 10 mg lyophilized
Compound ClassSynthetic Cyclic Peptide · Melanocortin Receptor Agonist · α-MSH analog
FormLyophilized powder in sterile glass vial
Quantity10 mg per vial
CAS Number121062-08-6
Chemical FormulaC50H69N15O9
Molar Mass1,024.18 g/mol
Half-Life~2 hours
Amino Acid SequenceAc-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2
SynonymsMelanotan II, MT-2, MT-II, MTII
Net Peptide Content≥96% (includes stabilizing agents)
Verified PurityBatch-tested to 99.63% (HPLC)

For laboratory research use only. Not for human or animal consumption.

View certificates of analysis
Sourcing & quality

Why source Melanotan II from Sports Technology Labs

Quality control across the research-peptide industry is inconsistent, and many suppliers do not publish third-party testing for their products. Independent verification of identity and purity is essential for reproducible research.

Third-party tested & certified

Verified by MZ Biolabs (Tucson, AZ), an accredited US laboratory, via HPLC and mass spectrometry, with batch-linked COAs.

Lyophilized & packaged in America

Freeze-dried into sterile, UV-resistant glass vials and packaged in the USA.

Tamper-evident packaging

Supports chain-of-custody, label transparency, and batch-linked traceability.

60-day money-back guarantee

Transparent business, standard payment methods, no misrepresentation.

Research context

What is Melanotan II?

Melanotan II (MT-2) is a synthetic cyclic heptapeptide analog of α-melanocyte-stimulating hormone (α-MSH), an endogenous melanocortin peptide. Mechanistically, it acts as a non-selective agonist of the melanocortin receptors, with reported activity at MC1R, MC3R, and MC4R.

It is studied as a research chemical to investigate melanocortin-receptor biology in experimental models. Published characterization focuses on its receptor-binding profile as a structurally constrained α-MSH analog.

Melanotan II is an experimental research chemical, supplied strictly for laboratory research. Sports Technology Labs makes no claims regarding its effects, and nothing in this listing should be interpreted as describing outcomes in humans or animals.

Regulatory & compliance status

Important regulatory information

Not approved for human use

Melanotan II is an investigational research peptide. It is not approved by the FDA and is not a drug, food, dietary supplement, or cosmetic. Marketing it for human use is unlawful.

WADA status

Melanocortin receptor agonists such as Melanotan II are not currently listed on the World Anti-Doping Agency Prohibited List.

Legal status varies by jurisdiction

In the United States, Melanotan II is not a controlled substance and may be legally purchased and possessed for laboratory research use. In some other countries it is restricted as an unlicensed medicine.

Our position

Sports Technology Labs are chemical suppliers, not medical providers. We do not condone or encourage consumer use of research compounds.

Citations

Scientific references

  1. Al-Obeidi F, Hadley ME, Pettitt BM, Hruby VJ. Design of a new class of superpotent cyclic α-melanotropins based on quenched dynamic simulations. J Am Chem Soc. 1989;111(9):3413–3416.
  2. National Center for Biotechnology Information. PubChem Compound Summary for Melanotan II (CAS 121062-08-6): sequence, molecular formula, and molecular weight. PubChem, National Library of Medicine.

Research use only. All products on this website are intended exclusively for laboratory research and development. They are not for human or animal consumption. These statements have not been evaluated by the U.S. Food and Drug Administration, and these products are not intended to diagnose, treat, cure, or prevent any disease.

Additional information

Weight 0.25 oz
Dimensions 2 × 1 × 1 in

Melanotan II

Third-party verified by MZ Biolabs (Tucson, AZ), a US DEA Schedule III licensed facility (License: RP0584676). Every batch undergoes rigorous HPLC purity analysis and Mass Spectrometry identity confirmation under Good Laboratory Practice (GLP) standards to ensure 99%+ purity and research reproducibility.

  • Date: 10/17/2025
  • Purity Level: 99.63%

Certificate of Analysis showing HPLC purity test results for research-grade Melanotan II compound from MZ Biolabs

View all COAs at the bottom of this tab.

Melanotan II and Tanning

Melanotan has demonstrated significant effects on melanin production (melanogenesis), also known as “sunless tanning” or skin tanning without sun exposure. It does so by binding primarily to MC-1R and MC-4R, and has lesser effects in MC-3R, three of the five melanocortin receptors in the body. MC-1R is found in melanocytes in the skin and is primarily involved in the darkening of the skin, and helps the skin produce melanin. In contrast, MC-3R is involved in appetite and impulse control, and MC-4R is involved in sexual arousal, libido, and male erectile functionality.

It is critical to note that long-term side effects of sunless tanning, including the use of melanotan II peptides, have not been established, and that treatment with prolific agents like MT-2 may potentially stimulate the proliferation of existing skin cancer.

Melanotan II and Receptor Expression

MT-2 was found to decrease fat storage and hunger behavior in animal models. Research suggests that MT-2 has similar effects to the hormone leptin and could be effective for reducing hunger by stimulating both leptin-dependent and leptin-independent pathways. Both MT-2 and leptin are thought to cause an increase in thyrotropin-releasing hormone (TRH) gene expression and the MC-4R pathway, stimulating a region of the brain associated with satiety and food intake.

MT-2 is one of the very few substances that cross into the central nervous system in sufficient quantities to have an effect on TRH expression. Mice given Melanotan II demonstrated minimal affinity for dietary fat and satiety with lower caloric intake.

Melanotan II and Impulse Control/Addiction

MT-2 might play a role in impulse control by affecting oxytocin signaling. Studies have shown in rats that prefer alcohol that administration of MT-2 reduces alcohol intake and increases water intake. Melanotan II also works synergistically with Naltrexone to reduce alcohol consumption several-fold. More research is needed in this potential avenue for Melanotan therapy.

Melanotan II and the Features of Autism

In a common mouse model of Autism Spectrum Disorder (ASD), administration of MT-2 reversed certain features of Autism. The research showed that MT-2 administration increased oxytocin receptor expression, communication, and social interaction, while decreasing repetitive behaviors associated with ASD. This suggests a direct correlation between oxytocin signaling in the brain and ASD behavior.

Melanotan II Libido and Erectile Dysfunction

MT-2 has demonstrated efficacy in treatment for ED that has been shown to work in 80% of cases of failed treatment with other ED medications. MT-2 has also been investigated as a treatment for both male and female sexual desire disorders and may improve libido and sexual arousal. Recent research suggests that MT-2 can have even more wide-ranging applications than other ED drugs due to its actions in the central nervous system, and not just vasodilation.

Melanotan and Dementia

Research on Alzheimer’s disease indicates that Melanotan II peptides may reduce beta amyloid accumulation and decrease the A1 subtype of reactive astrocytes, which are believed to contribute heavily to neurotoxicity and neuron death in Alzheimer’s Disease. More research is needed to establish a definitive link between Melanotan and dementia.

Data on Our Melanotan II For Sale

CAS Number: 121062-08-6

Formula: C50H69N15O9

Sequence: Ac-Nle-cyclo [Asp-His-D-Phe-Arg-Trp-Lys]-NH2

Molar Mass: 1,024.18 g/mol

Half-life: 2 hours

Class: Peptide

Storage: Keep refrigerated upon reconstitution.

  • Lyophilized sample in a sterile glass vial.
  • Minimum 96% pure (includes stabilizing agents)
  • 10 mg Melanotan II per vial.
  • Diluent and laboratory supplies are not included.

SKU: 42

Abuse Warning

This preparation is for in vitro laboratory research purposes only by licensed professionals and is not approved by the FDA for bodily introduction of any kind into humans or animals. Melanotan II is not a drug, food, supplement, or cosmetic and may not be misbranded, misused, or mislabeled as a drug, food, supplement, or cosmetic.

Scientific References:

1. Minakova E, Lang J, Medel-Matus JS, Gould GG, Reynolds A, Shin D, Mazarati A, Sankar R. Melanotan-II reverses autistic features in a maternal immune activation mouse model of autism. PLoS One. 2019 Jan 10;14(1):e0210389. doi: 10.1371/journal.pone.0210389. PMID: 30629642; PMCID: PMC6328175.

2. Shimizu H, Inoue K, Mori M. The leptin-dependent and -independent melanocortin signaling system: regulation of feeding and energy expenditure. J Endocrinol. 2007 Apr;193(1):1-9. doi: 10.1677/JOE-06-0144. PMID: 17400797.

3. Bjørbaek C, Hollenberg AN. Leptin and melanocortin signaling in the hypothalamus. Vitam Horm. 2002;65:281-311. doi: 10.1016/s0083-6729(02)65068-x. PMID: 12481551.

4. Guo F, Bakal K, Minokoshi Y, Hollenberg AN. Leptin signaling targets the thyrotropin-releasing hormone gene promoter in vivo. Endocrinology. 2004 May;145(5):2221-7. doi: 10.1210/en.2003-1312. Epub 2004 Feb 5. PMID: 14764630.

5. York DA, Boghossian S, Park-York M. Melanocortin activity in the amygdala influences alcohol intake. Pharmacol Biochem Behav. 2011 Mar;98(1):112-9. doi: 10.1016/j.pbb.2010.12.010. Epub 2010 Dec 15. PMID: 21167196.

6. Wessells H, Fuciarelli K, Hansen J, Hadley ME, Hruby VJ, Dorr R, Levine N. Synthetic melanotropic peptide initiates erections in men with psychogenic erectile dysfunction: double-blind, placebo-controlled crossover study. J Urol. 1998 Aug;160(2):389-93. PMID: 9679884.

7. Lau JKY, Tian M, Shen Y, Lau SF, Fu WY, Fu AKY, Ip NY. Melanocortin receptor activation alleviates amyloid pathology and glial reactivity in an Alzheimer’s disease transgenic mouse model. Sci Rep. 2021 Feb 23;11(1):4359. doi: 10.1038/s41598-021-83932-4. PMID: 33623128; PMCID: PMC7902646.

8. Navarro M, Carvajal F, Lerma-Cabrera JM, Cubero I, Picker MJ, Thiele TE. Evidence that Melanocortin Receptor Agonist Melanotan-II Synergistically Augments the Ability of Naltrexone to Blunt Binge-Like Ethanol Intake in Male C57BL/6J Mice. Alcohol Clin Exp Res. 2015 Aug;39(8):1425-33. doi: 10.1111/acer.12774. Epub 2015 Jun 24. PMID: 26108334; PMCID: PMC4515169.