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S4, also known as Andarine, was developed to test effects on muscle wasting, osteoporosis, and benign prostatic hypertrophy.
In a rat model, 1.6mg/kg bodyweight has been shown to significantly increase bone mineral density, lean mass and body composition. 3mg/kg/day demonstrated significant increases in muscle mass .
In the ovariectomized rat model for osteoporosis, 3 and 10mg/kg/day were administered for 8 weeks and both groups showed improvements in whole body and trabecular bone mineral density, cortical content, and decreased body fat.
Primary culture of bone marrow osteoprogenitor cells showed that S4 was more anabolic than DHT for promoting osteoblast formation, further confirming its anabolic potential in bone tissue.
Andarine Research
Partial agonists like S4, in the presence of full agonists like Testosterone or DHT can behave as competitive antagonists depending on the tissue.
S4 has been shown to decrease prostate weight with similar efficacy to 5mg/kg finasteride without affecting levator ani muscles.
This suggests that SARMS may be an ideal candidate for reducing prostate size much like SERMs are used to decrease breast tissue.
S4 was ultimately abandoned in clinical trials because subjects experienced blurred vision at night accompanied by a yellowish vision tint during the day.
Research in Mice
A recent animal study aimed to characterize the full agonist activity of chemical name S3 or (4-acetylamino-phenoxy)-2-hydroxy 2 methyl N 4 nitro 3 trifluoromethyl phenyl)-propionamide (S4).
The research study tested subjects related to skeletal muscle, bone, and the pituitary of castrated male rats. To achieve this, the researchers treated the rats with S-4 andarine, dihydrotestosterone (DHT), or vehicle for 8 weeks, starting 12 weeks after castration.
The results showed that S-4 andarine restored soleus muscle mass and muscle strength and levator ani muscle mass to that seen in intact animal subjects, similar to the effects observed in DHT treated animals.
However, compared to DHT, S4 andarine had minimal pharmacologic effects in the prostate, with only 16 and 17% restoration of prostate and seminal vesicle weights, respectively, to the control levels.
Moreover, S4 and DHT restored castration-induced loss in lean body mass, with S-4 causing a significantly larger increase in total body bone mineral density than DHT. S-4 also demonstrated agonist activity in the pituitary and significantly decreased LH and decreased FSH levels in castrated animals.
In conclusion, the study showed that S-4 had strong anabolic effects in skeletal muscle, bone, and pituitary with minimal pharmacologic effects in the prostate. It is to be noted that this study did not test the prostate glands, bone density, skeletal muscle, or other compounds.
What Benefits of S4 Are Researchers Testing?
1. The effect on muscles mass and bone mineral density.
2. The effect on body fat.
3. The effect on the prostate gland and androgens like Testosterone and DHT .
Andarine is also available in pure powdered form here.
AT THIS TIME, ANDARINE / S4 IS ONLY APPROVED FOR LABORATORY RESEARCH AND IS NOT SOLD FOR HUMAN CONSUMPTION.
Sports Technology Labs
Sports Technology Labs is the best place to buy S4 as we value our great customer service, fast shipping, and high quality products. If you have any questions related to S4 or other SARMs, please feel free to reach out to our team and have your questions answered promptly.
Abuse Warning
S4 is an investigational compounds still awaiting FDA approval and are not dietary supplements. At Sports Technology Labs we are chemical suppliers, not medical doctors, and our expertise is sourcing and quality control.
Sports Technology Labs does not encourage or condone consumer use of SARMs products, they are for research purposes only.
Anecdotal reports and guides may not match those used in carefully designed medical research protocols and may pose a serious risk of adverse effects in users.
Individual variables, comorbidities, and polypharmacy can also contribute significantly to the risk of health problems.
Scientific References:
1. Hott JL, Borkman RF (November 1989). “The non-fluorescence of 4-fluorotryptophan”. The Biochemical Journal. 264 (1): 297–9. doi:10.1124/jpet.102.040840. PMC 1133577. PMID 2604714
2. Gao W, Reiser PJ, Coss CC, Phelps MA, Kearbey JD, Miller DD, Dalton JT. Selective androgen receptor modulator treatment improves muscle strength and body composition and prevents bone loss in orchidectomized rats. Endocrinology. 2005;146:4887–4897.
3. Kearbey JD, Gao W, Miller DD, Dalton JT. Selective androgen receptor modulators inhibit bone resorption in rats. AAPS PharmSci. 2003;5
4. Gao W, Kearbey JD, Nair VA, Chung K, Parlow AF, Miller DD, Dalton JT. Comparison of the pharmacological effects of a novel selective androgen receptor modulator, the 5alpha-reductase inhibitor finasteride, and the antiandrogen hydroxyflutamide in intact rats: new approach for benign prostate hyperplasia. Endocrinology. 2004;145:5420–5428
5. Gao W, Reiser PJ, Coss CC, Phelps MA, Kearbey JD, Miller DD, Dalton JT. Selective androgen receptor modulator treatment improves muscle strength and body composition and prevents bone loss in orchidectomized rats. Endocrinology. 2005 Nov;146(11):4887-97. doi: 10.1210/en.2005-0572. Epub 2005 Aug 11. PMID: 16099859; PMCID: PMC2039881.
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