PEG-MGF, short for Pegylated Mechano Growth Factor, is a variant of the Insulin-like Growth Factor-1 (IGF-1). This peptide hormone plays a critical role in stimulating muscle growth.
The ‘PEG’ portion refers to polyethylene glycol, which allows the molecule to remain active in the body for more extended periods compared to standard insulin-like growth factor-1.
FAQs Related to Pegylated Mechano Growth Factor
The potential benefits of PEG-MGF being studied include effects on:
PEG-MGF is not currently approved for human use by the FDA. However, it is not illegal to buy or sell it for research purposes only.
PEGylation is the process of attaching polyethylene glycol (PEG) polymer chains to proteins, peptides, or small molecules. PEG is a water-soluble polymer that the FDA has approved for use in pharmaceuticals.
Why Buy PEG-MGF From Sports Technology Labs?
If you are trying to figure out where to buy PEG-MGF peptide, there are many options out there. To buy PEG-MGF from a randomly selected company is dangerous.
Most companies with peptides for sale, sad to say, do not test their products, or hide their certificates or contact information for their third-party labs from customers. What can they be hiding?
At Sports Technology Labs, you can find the highest quality PEG-MGF for sale anywhere on the internet. When you buy peptides from Sports Technology Labs, you are choosing the highest quality products.
Pure compounds are tested and certified by accredited American third-party labs that accept phone calls to verify the validity of their certificates. Our products are lyophilized in glass bottles and are stored in refrigeration to prevent degradation.
We run a transparent business, with no discreet payment methods necessary and no misrepresentation of our products, only the highest quality research chemicals available online, secured by our 60-day money-back guarantee. For orders totaling $149 or more, we offer free shipping.
If you’re in a hurry to receive your products, we also provide express shipping options. Additionally, customers who sign up for our email list receive a 10% discount and an additional 10% off when paying with cryptocurrency.
Sports Technology Labs is the best place to buy PEG-MGF peptide online because of our consistent, verifiable, high-quality products, safe bottling and packaging, fast shipping, and great customer service. And if you have any questions about our Pegylated Mechano Growth Factor and other products, you can also contact us, and we’ll respond as soon as possible.
Additional information
Weight
0.25 oz
Dimensions
2 × 1 × 1 in
PEG MGF
All Sports Technology Labs peptides are third-party tested by MZ Biolabs, an independent laboratory based in Arizona. While not bottled in the USA, every batch is tested here to verify accuracy and purity. Our Certificates of Analysis confirm that products meet the listed specifications.
Mechano Growth Factors (MGF) naturally occur in the body during physical activity, especially after resistance training sessions where muscle tissues undergo damage. The natural MGF is quickly broken down in our bodies. Pegylation allows for a longer duration of activation, enabling it to help muscles grow and recover more effectively.
Pegylation and Its Benefits
Pegylation, or attaching polyethylene glycol (PEG) chains onto molecules, enhances their stability and solubility. Due to dissimilar molecular properties, some compounds are not readily taken up by our bodies.
Pegylation helps overcome these issues. When referring to PEG-MGF, pegylation ensures its effective absorption, resulting in increased effectiveness and duration within the body.
The Ability of PEG to Promote Muscle Fiber Formation
Researchers have explored using polyethylene glycol (PEG) to stimulate the fusion of muscle cells and the formation of muscle fibers. As described in a recent study, PEG can effectively promote muscle cell fusion and fiber formation both in laboratory cell cultures and in living mice.
Scientists believe that PEG stimulates muscle cell fusion through its hydrophobic properties and ability to dehydrate cell membranes. This brings myoblasts into closer contact, enabling their fusion into myotubes and mature fibers. Through this mechanism, PEG holds promise as a novel agent to enhance muscle growth and regeneration.
The ability to fuse muscle cells using PEG establishes it as a tool to promote muscle tissue formation both in the laboratory and for therapeutic applications. Further research will help optimize PEG for muscle cell fusion and explore its potential uses in treating muscle damage or atrophy.
Mechanogrowth Factor and the Heart
A recent study examined the effects of delivering a synthetic peptide from the mechano-growth factor (MGF) to the heart after a myocardial infarction. MGF is expressed in the heart after an infarction.
The researchers made peptide-eluting microstructures the size of cardiac myocytes using a hydrogel polymer. These were injected into the hearts of mice after an artery ligation to mimic infarction.
The study found that untreated mice had declining cardiac function and pathological hypertrophy by 2 weeks after infarction. This declined further by 10 weeks. Improvements to aid the heart muscle cells’ function were tested.
Mice treated with the MGF peptide microstructures had decreased mortality, better hemodynamics, and delayed decompensation compared to controls. The peptide appeared to inhibit pathological hypertrophy despite increased vascular impedance.
Empty microstructures also decreased ventricular stiffness but did not affect hypertrophy. Overall, the targeted delivery of the MGF peptide to the heart after chronic or acute myocardial infarction reduced adverse remodeling and improved cardiac function. The peptide may help prevent the adverse outcomes of myocardial infarction.
MGF Peptide Protects Against Brain Ischemia
A novel therapy using the MGF peptide derived from insulin-like growth factor-1 shows promise for protecting the brain after ischemic injury. As reported in a recent study, the MGF peptide has a robust neuroprotective effect when administered after induced brain ischemia in rats. The researchers found that MGF peptide treatment significantly reduced neuronal cell death and infarct size compared to controls.
It also improved functional recovery, decreasing the sensorimotor deficits caused by loss of brain tissue after ischemia. The neuroprotective benefits stem from MGF’s ability to activate cell survival signaling pathways and suppress apoptosis. This minimizes damage when blood flow and oxygen are disrupted.
Because MGF peptide retains the neuroprotective activity of the complete IGF-1 molecule, it represents a more targeted therapeutic agent for cerebral ischemia. The results demonstrate that MGF may be an effective emergency treatment to prevent permanent brain injury after stroke or similar events.
Further evaluation of this neuroprotective peptide could lead to improved outcomes for patients at risk of brain ischemia.
This preparation is for in vitro laboratory research purposes only by licensed professionals and is not approved by the FDA for bodily introduction of any kind into humans or animals. PEG-MGF is not a drug, food, supplement, or cosmetic and may not be misbranded, misused, or mislabeled as a drug, food, supplement, or cosmetic.
References:
1. Peña, J. R., Pinney, J. R., Ayala, P., Desai, T. A., & Goldspink, P. H. (2015). Localized delivery of mechano-growth factor E-domain peptide via polymeric microstructures improves cardiac function following myocardial infarction. Biomaterials, 46, 26-34.
2. Zabłocka, B., Goldspink, P. H., Goldspink, G., & Górecki, D. C. (2012). Mechano-growth factor: an important cog or a loose screw in the repair machinery?. Frontiers in endocrinology, 3, 131.
3. Alagaratnam, S., Yang, S. Y., Loizidou, M., Fuller, B., & Ramesh, B. (2019). Mechano-growth Factor Expression in Colorectal Cancer Investigated With Fluorescent Gold Nanoparticles. Anticancer Research, 39(4), 1705-1710.
4. McVeigh, J., Chandler, M., & Yarwood, G. A. (2023). Exercise and Performance-Enhancing Drugs within The Body in the Mind: Exercise Addiction, Body Image and the Use of Enhancement Drugs, 4(7), 121.
5. Veronese, F. M., & Pasut, G. (2005). PEGylation is a successful approach to drug delivery. Drug discovery today, 10(21), 1451-1458.
