NAD+ Research Products: A Key to Cellular Health and Longevity
What is NAD+?
Nicotinamide adenine dinucleotide (NAD+) is a critical coenzyme found in every cell of the body, essential for energy metabolism, DNA repair, and overall cellular function. As a vital molecule, NAD+ plays a role in fundamental biological processes, including mitochondrial function, cellular aging, and oxidative stress resistance. However, NAD+ levels decline with age, leading to metabolic inefficiencies and increased susceptibility to age-related conditions. This age-related NAD decline is significant for understanding the metabolic changes and oxidative stress that accompany aging.
Frequently Asked Questions (FAQs)
NAD+ research products are compounds designed for scientific research purposes to explore their effects on cellular function, metabolism, and longevity. These products are used to study their effects on cells. These products are not dietary supplements or intended for human consumption but are used in laboratory settings to study NAD+ metabolism and its role in biological processes.
NAD+ research products function by increasing intracellular NAD+ levels, which support mitochondrial energy production, cellular repair, and stress response mechanisms. Mitochondrial NAD plays a crucial role in regulating mitochondrial function and energy production, which is essential for maintaining cellular health. They are commonly used to study aging, cognitive function, and metabolic health in controlled research environments.
–Nicotinamide Mononucleotide (NMN): A direct precursor to NAD+ that is converted in a single enzymatic step. The role of salvage pathways in NAD+ biosynthesis from these precursors is crucial, as they involve specific enzymes like NAMPT that can be targeted to enhance NAD+ production.
–Nicotinamide Riboside (NR): Another NAD+ precursor that undergoes multiple conversion steps before forming NAD+.
–Nicotinamide (NAM) and Tryptophan: Alternative pathways to NAD+ synthesis, often studied for their role in cellular health.
Each of these compounds is used in research to analyze different aspects of NAD+ metabolism.
NAD+ research products are strictly intended for research purposes and are not approved for human consumption. Human clinical trials are crucial in evaluating the safety and efficacy of NAD+ augmentation therapies. Studies on research subjects suggest potential benefits, but further research is needed to determine long-term effects and optimal applications. Some formulations may require refrigeration to maintain potency, depending on the compound’s stability profile.
For best stability, NAD+ research products should be stored in a cool, dry place, away from direct sunlight. Some formulations may require refrigeration to maintain potency, depending on the compound’s stability profile.
Why buy NAD+ from Sports Technology Labs?
When it comes to purchasing NAD+, you have a variety of options, but not all sources are trustworthy. Buying NAD+ from an unverified company can be risky. Many companies selling peptides and supplements do not provide transparent testing results or hide their third-party lab certificates from customers—what are they trying to conceal?
At Sports Technology Labs, you’ll find the highest quality NAD+ products available online. When you choose us, you’re selecting a reliable source with rigorously tested and certified NAD+.
Our NAD+ products are pure compounds that accredited American third-party labs have tested. We even provide you with direct contact information for these labs, so you can personally verify the authenticity of their certificates.
We prioritize quality and safety. Our NAD+ is lyophilized and stored in glass vials, kept refrigerated to prevent degradation. Transparency is key in our business, and we stand by our products with no hidden fees or deceptive practices. We offer only the best research chemicals, backed by our 60-day money-back guarantee.
Sports Technology Labs is the best place to buy NAD+ online because we offer consistently high-quality products that are safe, well-packaged, and shipped quickly. Orders over $149 qualify for free shipping, and we also provide express shipping for those in a hurry. Plus, if you sign up for our email list, you’ll get a 10% discount, with an additional 10% off when you pay with cryptocurrency.
If you have any questions about our NAD+ or other products, don’t hesitate to contact us—we’re here to help!
Conclusion
NAD+ is a fundamental molecule for maintaining optimal cellular function, metabolic health, and longevity. By supporting mitochondrial efficiency, cognitive health, and cardiovascular function, NAD+ research products represent a promising avenue for scientific investigation in health optimization.
Additional information
Weight
0.25 oz
Dimensions
2 × 1 × 1 in
NAD+
All Sports Technology Labs peptides are third-party tested by MZ Biolabs, an independent laboratory based in Arizona. While not bottled in the USA, every batch is tested here to verify accuracy and purity. Our Certificates of Analysis confirm that products meet the listed specifications.
Mechanisms of NAD+ Research Products in DNA Repair
Several pathways exist to increase NAD+ levels through research applications. Understanding the molecular mechanisms involved in NAD+ metabolism is critical, as these mechanisms influence various cellular functions and health outcomes, particularly in the context of age-related diseases and inflammation:
Nicotinamide Riboside (NR): A direct precursor that efficiently raises NAD+ levels.
Nicotinamide Mononucleotide (NMN): Converts to NAD+ in a single enzymatic step.
Tryptophan and Nicotinic Acid: Alternative dietary precursors involved in NAD+ biosynthesis.
CD38 Inhibition: CD38 is an enzyme that depletes NAD+, and reducing its activity may help sustain NAD+ levels
The Role of NAD+ in Energy Production and Cellular Metabolism
NAD+ is indispensable in ATP production through cellular respiration. It acts as a key electron transporter in metabolic pathways, including glycolysis, the Krebs cycle, oxidative phosphorylation, and fatty acid oxidation. Depleted NAD+ levels can reduce ATP production, leading to mitochondrial dysfunction and decreased energy availability.
NAD+ and Age-Related NAD Decline in Cellular Aging
One of the most significant discoveries regarding NAD+ is its role in aging and longevity. NAD+ plays a crucial role in preventing cellular senescence, a state where cells become irreversibly arrested in their cycle due to various stresses. NAD+ is required for the activation of sirtuins, a family of proteins involved in DNA repair, inflammation regulation, and cellular stress responses. Studies indicate that increasing NAD+ levels promote cellular health and longevity by supporting sirtuin activity.
Targeting NAD+ Decline
NAD+ decline is a hallmark of the aging process and is associated with various age-related diseases, including metabolic disorders, neurodegenerative diseases, and cancer. Research is being conducted to target NAD+ decline and offer a promising approach to prevent and treat these conditions.
One effective strategy being studied to increase NAD+ levels is through NAD+ precursors, such as nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN). These precursors have been shown to boost NAD+ levels, enhancing metabolic function, cognitive performance, and exercise capacity. By replenishing NAD+ stores, these products may help mitigate the effects of aging and improve overall health.
In addition to this method, small-molecule inhibitors targeting NAD+-consuming enzymes, such as PARPs and CD38, have been developed. These inhibitors work by reducing the consumption of NAD+, thereby increasing its availability for other cellular processes. Research has demonstrated that these compounds can enhance NAD+ levels, improving metabolic and cognitive functions.
While targeting NAD+ decline holds great promise, further research is needed to understand the underlying mechanisms and optimize these strategies fully. Continued investigation will help develop effective ways to combat age-related diseases and promote healthy aging.
By exploring these avenues, scientists aim to unlock the potential of NAD+ in enhancing cellular health and longevity, paving the way for innovative treatments and improved quality of life.
NAD+ and Cognitive Function
Cognitive decline is often associated with reduced NAD+ levels in the brain. NAD+ metabolism plays a crucial role in the functionality of adult neural stem cells, impacting their regenerative capabilities and overall health during aging. Research suggests that NAD+ precursors, such as nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN), may help maintain neuronal health, protect against neurodegenerative disorders, and support cognitive function.
Cardiovascular and Metabolic Benefits
NAD+ has been linked to cardiovascular health by improving vascular function, reducing arterial stiffness, and enhancing mitochondrial efficiency. NAD+ also influences gene expression related to cardiovascular health, affecting the regulation of genes involved in vascular function and heart disease. Research subjects receiving NAD+ research products have shown improvements in metabolic flexibility, insulin sensitivity, and overall heart function.
NAD+ Metabolism and Biosynthesis
NAD+ metabolism and biosynthesis are intricate processes that involve multiple pathways and enzymes working in concert. One of the primary sources of NAD+ in the body is the kynurenine pathway, which starts with the amino acid tryptophan. Through a series of enzymatic reactions, tryptophan is converted into kynurenine, which is then transformed into nicotinic acid (NA) and eventually into NAD+. This pathway is crucial for maintaining NAD+ levels, especially in tissues with high energy demands.
Another significant pathway contributing to NAD+ biosynthesis is the Preiss-Handler pathway. This pathway involves the conversion of nicotinic acid to NAD+, providing an alternative route for NAD+ production. Additionally, the salvage pathway plays a vital role in recycling nicotinamide (NAM) and nicotinamide riboside (NR) back into NAD+. This recycling process is essential for sustaining NAD+ levels, particularly in cells that require a constant energy supply.
The regulation of NAD+ biosynthesis is a tightly controlled process, governed by various enzymes and transcription factors. These regulatory mechanisms ensure that NAD+ levels remain within a narrow range, maintaining cellular homeostasis and preventing metabolic disorders. By understanding these pathways and their regulation, researchers can develop strategies to enhance NAD+ levels, potentially improving cellular health and longevity.
NAD+ Catabolism and Consumption
NAD+ catabolism and consumption are equally important in regulating NAD+ levels within the body. Several enzymes, including poly(ADP-ribose) polymerases (PARPs), sirtuins, and CD38, consume NAD+ to perform critical cellular functions.
PARPs are a family of enzymes that play a pivotal role in DNA repair and maintaining genomic stability. They utilize NAD+ to synthesize poly(ADP-ribose) chains, which are essential for repairing DNA damage. This process is crucial for protecting cells from genomic instability and preventing diseases such as cancer.
Sirtuins, another family of NAD+-dependent enzymes, are involved in regulating cellular metabolism, stress resistance, and longevity. By consuming NAD+, sirtuins deacetylate proteins, influencing various metabolic pathways and promoting cellular health. CD38, a NAD+-consuming enzyme, is vital for regulating calcium signaling and immune function, further highlighting the diverse roles of NAD+ in cellular processes.
The catabolism and consumption of NAD+ are tightly regulated through feedback inhibition and transcriptional control. These regulatory mechanisms ensure that NAD+ levels are maintained, supporting cellular metabolism and preventing metabolic dysfunction. Understanding these processes is crucial for developing therapeutic strategies to modulate NAD+ levels and improve health outcomes.
NAD+, Muscle Recovery, and Mitochondrial Function
NAD+ research products are being studied for their effect on muscle recovery, endurance, and mitochondrial biogenesis, with animal studies underway. Increasing NAD+ levels plays a crucial role in skeletal muscle health and recovery. Studies have demonstrated that increasing NAD+ availability can improve exercise performance. The studies show that it reduces oxidative stress and supports cellular repair mechanisms.
Data on our NAD+ for sale
CAS Number: 53-84-9
Formula: C21H27N7O14P2
Molar Mass: 663.43 g/mol
Class: Co-enzyme
Storage: Keep refrigerated upon reconstitution.
Lyophilized sample in a sterile glass vial.
Minimum 98% pure.
500 mg NAD+ per vial.
Diluent and laboratory supplies are not included.
SKU: 59
Potential Considerations and Safety
While research suggests numerous studies are currently being conducted, NAD+ research products require further investigation regarding long-term effects. Double blind, placebo-controlled studies are crucial in evaluating these products to ensure unbiased and rigorous results. Most studies report high tolerability with minimal side effects, though individual responses may vary.
This preparation is for in vitro laboratory research purposes only by licensed professionals and is not approved by the FDA for bodily introduction of any kind into humans or animals. NAD+ is not a drug, food, supplement, or cosmetic and may not be misbranded, misused, or mislabeled as a drug, food, supplement, or cosmetic.
2. Abdellatif, M., Bugger, H., & Kroemer, G. (2022). NAD+ and vascular dysfunction: from mechanisms to therapeutic opportunities. Journal of Lipid Research.
4. Hershberger, K. A., Martin, A. S., & Hirschey, M. D. (2017). Role of NAD+ and mitochondrial sirtuins in cardiac and renal diseases. Nature Reviews Nephrology.
5. Campbell, J. M. (2022). NAD+ research products and their potential in cognitive function.Nutrients.
6. Amjad, S., Nisar, S., & Bhat, A. A. (2021). Role of NAD+ in regulating cellular and metabolic signaling pathways. Molecular Metabolism.
7. Qin, Y. Y., et al. (2024). NAD+ homeostasis and its role in exercise adaptation: A comprehensive review.Free Radical Biology and Medicine.
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