Ipamorelin is a pentapeptide composed of a concise sequence of amino acids: Aib-His-D-2-Nal-D-Phe-Lys-NH2. This peptide is known for its ability to stimulate the pituitary gland to release growth hormone. It is also known for its positive impact on promoting lean muscle mass and facilitating weight loss. Moreover, it produces fewer effects on the:
cortisol release
thyroid-stimulating hormone
luteinizing hormone
prolactin
follicle-stimulating hormone
ACTH
Ipamorelin FAQs
Ipamorelin is a short sequence peptide with a growth hormone-releasing effect
Stimulates growth hormone release from the pituitary gland
Little effect on thyroid-stimulating hormone, luteinizing hormone, prolactin, follicle-stimulating hormone, ACTH, or cortisol release
Reduces/reverses side effects of glucocorticoid use
Decreases muscle wasting and improves nitrogen balance
It slows or stops bone loss, increases bone formation, and increases mineral density.
Stimulates insulin release, with potential for preventing type 2 diabetes
Possible use in PET for cancer and heart failure diagnosis
Shortens clinical recovery time and improves eating ability in POI
Store in a cool, dark place
After reconstitution, store in the refrigerator
Refrigeration temperature: 10.25 degrees Celsius or 50.7 degrees Fahrenheit
Data show that Ipamorelin significantly increases circulating plasma growth hormone in mammals.
Ipamorelin is a delicate peptide that requires reconstitution and subcutaneous injection for optimal bioavailability, whereas MK-677 is bioavailable orally and is a more stable molecule with a longer shelf life.
CJC-1295 stimulates the release of growth hormone from the pituitary gland. Ipamorelin is a ghrelin agonist and stimulates both appetite and the production of growth hormones.
The most commonly reported side effects of Ipamorelin include nausea, increased thirst, water retention, injection site irritation, and the potential for insulin resistance or carpal tunnel syndrome.
Yes. In research models, Ipamorelin is often paired with CJC-1295 without DAC, which increases GH secretion via GHRH receptor pathways. This creates a synergistic effect, enhancing pulsatile GH release while maintaining physiological rhythm. (Source)
Ipamorelin has a half-life of approximately 2 hours in plasma. However, its GH-stimulating effects can last up to 4–6 hours post-administration, depending on the quantity and the subject’s response. (Source)
Why Buy Ipamorelin From Sports Technology Labs?
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At Sports Technology Labs, you can find the highest quality Ipamorelin for sale anywhere on the internet. When you purchase peptides from Sports Technology Labs, you select the highest-quality products.
Pure compounds are tested and certified by accredited American third-party labs that accept phone calls to verify the validity of their certificates. Our products are lyophilized in glass bottles and are stored in refrigeration to prevent degradation. We run a transparent business, with no discreet payment methods necessary and no misrepresentation of our products, only the highest quality research chemicals available online, secured by our 60-day money-back guarantee.
Sports Technology Labs is the best place to buy Ipamorelin online because of our consistent, verifiable, high-quality products, safe bottling and packaging, fast shipping, and excellent customer service. We provide free shipping for orders exceeding $149, and for those who require expedited delivery, we also offer express shipping. Customers who subscribe to our email list enjoy a 10% discount and an extra 10% off when paying with cryptocurrency. And if you have any questions about our Ipamorelin for sale for laboratory research use, please don’t hesitate to contact us.
Additional information
Weight
0.25 oz
Dimensions
2 × 1 × 1 in
Ipamorelin
All Sports Technology Labs peptides are third-party tested by MZ Biolabs, an independent laboratory based in Arizona. While not bottled in the USA, every batch is tested here to verify accuracy and purity. Our Certificates of Analysis confirm that products meet the listed specifications.
Ipamorelin is a selective growth hormone secretagogue (GHS) that mimics the action of ghrelin, a naturally occurring peptide in the stomach. It binds specifically to the growth hormone secretagogue receptor (GHS-R1a), primarily located in the pituitary gland and hypothalamus, triggering a cascade that results in the release of growth hormone (GH).
Unlike earlier GHS compounds (like GHRP-2 or GHRP-6), Ipamorelin:
Does not significantly stimulate cortisol or prolactin production (Source)
Exhibits high specificity for the GHS receptor (Source)
Has a longer half-life (~2 hours) than natural ghrelin, allowing for sustained GH release (Source)
This makes it ideal for research focused on GH modulation, anabolic studies, and muscle regeneration experiments without significantly impacting other hormonal axes.
Key Mechanistic Features
Target receptor: GHS-R1a
Effect: Pulsatile GH release without spike in ACTH/cortisol
Ipamorelin falls into the category of Growth Hormone-Releasing Peptides (GHRP), acknowledged for their ability to elevate growth hormone levels and offer a wide array of clinical advantages. These include:
The management of body fat and weight
The enhancement of skin elasticity and function
The reduction in cortisol production
The improvements in energy levels and sleep quality
Ipamorelin is frequently likened to GHRP-6 and GHRP-2 due to their shared similarities in mechanism, action, and functionality.
Side Effects from Glucocorticoids
Ipamorelin has shown potential in reducing or reversing the side effects of glucocorticoid use. The side effects from long-term glucocorticoid use can lead to inflammatory conditions such as cancer and autoimmune diseases. As well, they are known to decrease lean muscle tissue and intramuscular amino acids while increasing body fat. Stimulation of the pituitary gland with Ipamorelin may help reduce these effects.
Benefits Under Investigation With Ipamorelin
Muscle Wasting
Glucocorticoids can cause an unwanted side effect: muscle wasting. In recent studies on rats, glucocorticoid treatment was administered. As a result of the study, the rats had less amino acid wasting. This was seen in the liver, and there were also improved nitrogen balance levels in muscles.
Bone Loss Protection
When taking glucocorticoids for an extended period, diminished bone density can result, leading to a heightened susceptibility to fractures. Clinical investigations have shown the potential of Ipamorelin to counteract the bone loss associated with these corticosteroids. It does this by influencing the pituitary gland. This beneficial effect seen by this process was observed in experiments involving rats. The peptide actively stimulated bone formation during this clinical study. Furthermore, Ipamorelin has demonstrated the capability to help bone mineral density by reinforcing the structural integrity of both pre-existing and newly formed bones.
Potential Benefits for Diabetes
Research conducted on diabetic rats suggests that ipamorelin administration may stimulate insulin release by binding to the calcium channel found on pancreatic cells. These effects on the pancreas could potentially aid in the development of preventative measures for type 2 diabetes.
Ipamorelin and Post-Operative Ileus
Post-operative ileus (POI) is a condition characterized by the temporary paralysis of the gastrointestinal system, resulting in the inability to ingest nutrients through eating. This condition is common after specific types of surgery, particularly abdominal surgery. Ipamorelin has been investigated for its potential to shorten the clinical recovery time and improve the ability to eat in individuals affected by POI.
Diagnostic Applications in Cancer and Heart Failure
Ipamorelin, a peptide known for its interaction with the ghrelin receptor, demonstrates an increased affinity in specific scenarios, particularly in certain cancer types and instances of heart failure. Ongoing research endeavors are focused on exploring the prospective utility of Ipamorelin as a positron emission tomography (PET) probe, aimed at enhancing the diagnostic capabilities for these medical conditions. Preliminary in vitro investigations have yielded compelling evidence in favor of this notion, substantiating the potential efficacy of Ipamorelin as a PET probe.
Data on Our Ipamorelin For Sale
CAS Number: 170851-70-4
Formula: C38H49N9O5
Sequence: Aib-His-D-2-Nal-D-Phe-Lys-NH2
Molar Mass: 711.85 g/mol
Half-life: 2 hours
Class: Peptide
Storage: Keep refrigerated upon reconstitution.
Lyophilized sample in a sterile glass vial.
Minimum 99% pure.
5 mg Ipamorelin per vial.
Diluent and laboratory supplies are not included.
SKU: 43
Abuse Warning
This preparation is for in vitro laboratory research purposes only by licensed professionals and is not approved by the FDA for bodily introduction of any kind into humans or animals. Ipamorelin is not a drug, food, supplement, or cosmetic and may not be misbranded, misused, or mislabeled as a drug, food, supplement, or cosmetic.
Scientific References:
1. Raun K, Hansen BS, Johansen NL, Thøgersen H, Madsen K, Ankersen M, Andersen PH. Ipamorelin is the first selective growth hormone secretagogue. Eur J Endocrinol. 1998 Nov;139(5):552-61. doi: 10.1530/eje.0.1390552. PMID: 9849822.
2. Aagaard NK, Grøfte T, Greisen J, Malmlöf K, Johansen PB, Grønbaek H, Ørskov H, Tygstrup N, Vilstrup H. Growth hormone and growth hormone secretagogue effects on nitrogen balance and urea synthesis in steroid-treated rats. Growth Horm IGF Res. 2009 Oct;19(5):426-31. doi: 10.1016/j.ghir.2009.01.001. Epub 2009 Feb 23. PMID: 19231263.
3. Andersen NB, Malmlöf K, Johansen PB, Andreassen TT, Ørtoft G, Oxlund H. The growth hormone secretagogue ipamorelin counteracts the glucocorticoid-induced decrease in bone formation of adult rats. Growth Horm IGF Res. 2001 Oct;11(5):266-72. doi: 10.1054/ghir. 2001.0239. PMID: 11735244.
4. Svensson J, Lall S, Dickson SL, Bengtsson BA, Rømer J, Ahnfelt-Rønne I, Ohlsson C, Jansson JO. The GH secretagogues ipamorelin and GH-releasing peptide-6 increase bone mineral content in adult female rats. J Endocrinol. 2000 Jun;165(3):569-77. doi: 10.1677/joe. 0.1650569. PMID: 10828840.
5. Adeghate E, Ponery AS. Mechanism of ipamorelin-evoked insulin release from the pancreas of normal and diabetic rats. Neuro Endocrinol Lett. 2004 Dec;25(6):403-6. PMID: 15665799.
6. Fowkes MM, Lalonde T, Yu L, Dhanvantari S, Kovacs MS, Luyt LG. Peptidomimetic growth hormone secretagogue derivatives for positron emission tomography imaging of the ghrelin receptor. Eur J Med Chem. 2018 Sep 5;157:1500-1511. doi: 10.1016/j.ejmech.2018.08.062. Epub 2018 Aug 23. PMID: 30282322.
7. Beck DE, Sweeney WB, McCarter MD; Ipamorelin 201 Study Group. Prospective, randomized, controlled, proof-of-concept study of the Ghrelin mimetic ipamorelin for the management of postoperative ileus in bowel resection patients. Int J Colorectal Dis. 2014 Dec;29(12):1527-34. doi: 10.1007/s00384-014-2030-8. Epub 2014 Oct 21. PMID: 25331030.
8. Greenwood-Van Meerveld B, Tyler K, Mohammadi E, Pietra C. Efficacy of ipamorelin, a ghrelin mimetic, on gastric dysmotility in a rodent model of postoperative ileus. J Exp Pharmacol. 2012 Oct 19;4:149-55. doi: 10.2147/JEP.S35396. PMID: 27186127; PMCID: PMC4863553.
9. Ipamorelin Peptide: Exploring Its Potential in Growth Hormone Stimulation and Health. Peptide Information (2023).
