LGD-4033 is a 3rd generation non-steroidal oral SARM with a high affinity for the androgen receptor (Ki of ~1 nM). It is currently the second most popular SARM on the market. Unlike testosterone which exerts anabolic effects by the same pathway, LGD-4033 has high selectivity for receptors in skeletal muscle, bone, and connective tissue, with minimal affinity for receptors in the prostate, scalp and skin. It was developed by Ligand Pharmaceuticals to treat conditions such as muscle wasting and osteoporosis without the virilizing side effects of anabolic steroids .
Preclinical primate data showed a significant dose-dependent increase in lean body mass for male and female monkeys during 13 weeks of dosing at either 0.6, 3, 15, or 75 MG/KG of bodyweight . In addition to this, 70% of the increased body mass was retained after a 4 week recovery period. Only the 75mg/kg group stopped treatment after 48 days due to toxicity . This dose is significantly higher than the highest dose administered in human clinical trials (0.5, 1, and 2mg administered to humans respectively) .
A Phase 1 clinical trial with 76 adult male humans orally administered LGD-4033 at varying doses showed a dose-dependent increase in lean body mass and was well tolerated by all 76 subjects for 21 days [1,2]. Phase 2 clinical trials consisted of 120 patients recovering from hip fracture surgery. The participants either received a placebo, 0.5, 1, or 2mg LGD-4033 over 12 weeks . All doses of LGD-4033 created significant increases in total lean body mass and subjects exhibited dose dependent decreases in mean fat mass. Patients administered LGD-4033 showed improvements in serum procollagen type 1 propeptide (s-P1NP), a marker of bone anabolism, and improvements in 6-minute walk distance as compared to placebo. No significant adverse effects were reported in any of the study groups . Patients were assessed 12 weeks after completion of the trial, at which they maintained the muscle mass that they had gained from the drug .
Data on our Ligandrol for sale
CAS Number: 1165910-22-4
Molar Mass: 338.258 g/mol
Class: Selective Androgen Receptor Modulator
Experimental Application: Significant lean mass gain, improved strength, improved blood-flow, accelerated recovery, and fat burning.
Cited Research: Sports Technology Labs Research Blog
This preparation is for laboratory research purposes only and is not approved by the FDA for human use. Ligandrol/LGD-4033 IS NOT A DIETARY OR SPORTS SUPPLEMENT.
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1. Basaria et al. The Safety, Pharmacokinetics, and Effects of LGD-4033, a Novel Nonsteroidal Oral, Selective Androgen Receptor Modulator, in Healthy Young Men. The Journals of Gerontology: Series A, Volume 68, Issue 1, January 2013, Pages 87–95.
2. Fragkaki et al. Human in vivo metabolism study of LGD-4033. Drug Test Analysis. Drug Test Anal. 2018 Nov;10(11-12):1635-1645. doi: 10.1002/dta.2512. Epub 2018 Nov 8.
3. “Viking Therapeutics Initiates Phase 2 Trial of VK5211 in Patients Recovering From Hip Fracture.” FierceBiotech. Questex LLC, 03 Nov. 2015. Web. 21 Nov. 2016.
Liquid Ligandrol (LGD-4033) Review
Sports Technology Lab is a US manufacturer of the highest purity liquid Ligandrol (LGD-4033). All of our products were tested and certified by a third party research lab.
Product Brand: Sports Technology Labs
Product Currency: USD
Product Price: 49.99
Product In-Stock: InStock