Year: 2019

YK11: The Myostatin destroyer?

YK-11 is a synthetic SARM that is a gene-selective partial agonist of the androgen receptor. It was first studied in Japan in 2011 by researcher Yuichiro Kanno. YK-11 accelerates the translocation of the androgen receptor into the nuclear compartment where its amino-terminal domain (NTD) functions as a constitutive activator of androgen receptor target genes [1]. […]

Stenabolic and it’s powerful effects

SR9009 is not a SARM but rather a potent non-addictive Nootropic in the REV-ERB agonist category. REV-ERB proteins regulate the body’s core clock and circadian rythm [1], they alter the expression of genes involved in lipid and glucose metabolism, cartilage breakdown, and may reduce the risk of heart disease via atherosclerosis.Several studies suggest that SR9009 […]

What is RAD-140 (Testolone)?

RAD-140 is a SARM developed by Radius Health, Inc. for treatment of conditions like muscle wasting and breast cancer [1]. It exerts anabolic activity in muscle and connective tissue with little effect on the prostate and seminal vesicles. In addition, it may selectively compete and antagonize testosterone in these tissues. Scientists administered testosterone proprionate at […]

What is Andarine (S4)?

S4, also known as Andarine, was developed by GTX, inc for the treatment of muscle wasting, osteoporosis, and benign prostatic hypertrophy [1]. In a rat model, 1.6mg/kg bodyweight has been shown to significantly increase bone mineral density, lean mass and body composition. 3mg/kg/day demonstrated significant increases in muscle mass [1, 2]. In the ovariectomized rat […]

About LGD-4033

LGD-4033 is a 3rd generation non-steroidal oral SARM with a high affinity for the androgen receptor (Ki of ~1 nM). It is currently the second most popular SARM on the market. Unlike testosterone which exerts anabolic effects by the same pathway, LGD-4033 has high selectivity for receptors in skeletal muscle, bone, and connective tissue, with […]

What is GW501516 (aka Cardarine)? What You Need to Know

GW501516, also known as Cardarine, is not a SARM but rather a selective PPARδ and AMP-K modulator developed in a collaboration between Ligand Pharmaceuticals and GlaxoSmithKline for treatment of obesity, diabetes, dyslipidemia, cholesterol imbalance, and cardiovascular disease. PPARδ and AMP-K are the same pathways activated during exercise and are involved in energy production and fatty […]

What you need to know about the most widely researched SARM: MK-2866 (Ostarine)

MK-2866 also known as Ostarine is the most researched and most widely used SARM available. It was developed and researched by GTx laboratories as a potential therapeutic aid to prevent cancer-related muscle wasting [1].Ostarine binds selectively to androgen receptors in muscle, connective tissue, and bone while avoiding receptors in the hair and prostate. Androgen receptors […]